Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse
Nagaya, K; Motomura, K; Kukk, E; Fukuzawa, H; Wada, S; Tachibana, T; Ito, Y; Mondal, S; Sakai, T; Matsunami, K; Koga, R; Ohmura, S; Takahashi, Y; Kanno, M; Rudenko, A; Nicolas, C; Liu, XJ; Zhang, Y; Chen, J; Anand, M; Jiang, YH; Kim, DE; Tono, K; Yabashi, M; Kono, H; Miron, C; Yao, M; Ueda, K; Nagaya, K (reprint author), Kyoto Univ, Grad Sch Sci, Dept Phys, Kyoto 6068502, Japan.; Nagaya, K (reprint author), RIKEN Spring 8 Ctr, Sayo, Hyogo 6795148, Japan.
2016
发表期刊PHYSICAL REVIEW X
ISSN2160-3308
卷号6期号:2页码:
文章类型期刊文献
摘要Understanding x-ray radiation damage is a crucial issue for both medical applications of x rays and x-ray free-electron-laser (XFEL) science aimed at molecular imaging. Decrypting the charge and fragmentation dynamics of nucleobases, the smallest units of a macro-biomolecule, contributes to a bottom-up understanding of the damage via cascades of phenomena following x-ray exposure. We investigate experimentally and by numerical simulations the ultrafast radiation damage induced on a nucleobase analogue (5-iodouracil) by an ultrashort (10 fs) high-intensity radiation pulse generated by XFEL at SPring-8 Angstrom Compact free electron Laser (SACLA). The present study elucidates a plausible underlying radiosensitizing mechanism of 5-iodouracil. This mechanism is independent of the exact composition of 5-iodouracil and thus relevant to other such radiosensitizers. Furthermore, we found that despite a rapid increase of the net molecular charge in the presence of iodine, and of the ultrafast release of hydrogen, the other atoms are almost frozen within the 10-fs duration of the exposure. This validates single-shot molecular imaging as a consistent approach, provided the radiation pulse used is brief enough.
关键词Ionization Charge Molecules Operation Region Atoms
DOI10.1103/PhysRevX.6.021035
收录类别SCI
语种英语
WOS记录号WOS:000378057600001
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/25880
专题中科院上海应用物理研究所2011-2018年
通讯作者Nagaya, K (reprint author), Kyoto Univ, Grad Sch Sci, Dept Phys, Kyoto 6068502, Japan.; Nagaya, K (reprint author), RIKEN Spring 8 Ctr, Sayo, Hyogo 6795148, Japan.
推荐引用方式
GB/T 7714
Nagaya, K,Motomura, K,Kukk, E,et al. Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse[J]. PHYSICAL REVIEW X,2016,6(2):—.
APA Nagaya, K.,Motomura, K.,Kukk, E.,Fukuzawa, H.,Wada, S.,...&Nagaya, K .(2016).Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse.PHYSICAL REVIEW X,6(2),—.
MLA Nagaya, K,et al."Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse".PHYSICAL REVIEW X 6.2(2016):—.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Ultrafast Dynamics o(1317KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Nagaya, K]的文章
[Motomura, K]的文章
[Kukk, E]的文章
百度学术
百度学术中相似的文章
[Nagaya, K]的文章
[Motomura, K]的文章
[Kukk, E]的文章
必应学术
必应学术中相似的文章
[Nagaya, K]的文章
[Motomura, K]的文章
[Kukk, E]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。