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Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse
Nagaya, K; Motomura, K; Kukk, E; Fukuzawa, H; Wada, S; Tachibana, T; Ito, Y; Mondal, S; Sakai, T; Matsunami, K; Koga, R; Ohmura, S; Takahashi, Y; Kanno, M; Rudenko, A; Nicolas, C; Liu, XJ; Zhang, Y; Chen, J; Anand, M; Jiang, YH; Kim, DE; Tono, K; Yabashi, M; Kono, H; Miron, C; Yao, M; Ueda, K; Nagaya, K (reprint author), Kyoto Univ, Grad Sch Sci, Dept Phys, Kyoto 6068502, Japan.; Nagaya, K (reprint author), RIKEN Spring 8 Ctr, Sayo, Hyogo 6795148, Japan.
2016
Source PublicationPHYSICAL REVIEW X
ISSN2160-3308
Volume6Issue:2Pages:
Subtype期刊文献
AbstractUnderstanding x-ray radiation damage is a crucial issue for both medical applications of x rays and x-ray free-electron-laser (XFEL) science aimed at molecular imaging. Decrypting the charge and fragmentation dynamics of nucleobases, the smallest units of a macro-biomolecule, contributes to a bottom-up understanding of the damage via cascades of phenomena following x-ray exposure. We investigate experimentally and by numerical simulations the ultrafast radiation damage induced on a nucleobase analogue (5-iodouracil) by an ultrashort (10 fs) high-intensity radiation pulse generated by XFEL at SPring-8 Angstrom Compact free electron Laser (SACLA). The present study elucidates a plausible underlying radiosensitizing mechanism of 5-iodouracil. This mechanism is independent of the exact composition of 5-iodouracil and thus relevant to other such radiosensitizers. Furthermore, we found that despite a rapid increase of the net molecular charge in the presence of iodine, and of the ultrafast release of hydrogen, the other atoms are almost frozen within the 10-fs duration of the exposure. This validates single-shot molecular imaging as a consistent approach, provided the radiation pulse used is brief enough.
KeywordIonization Charge Molecules Operation Region Atoms
DOI10.1103/PhysRevX.6.021035
Indexed BySCI
Language英语
WOS IDWOS:000378057600001
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Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25880
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorNagaya, K (reprint author), Kyoto Univ, Grad Sch Sci, Dept Phys, Kyoto 6068502, Japan.; Nagaya, K (reprint author), RIKEN Spring 8 Ctr, Sayo, Hyogo 6795148, Japan.
Recommended Citation
GB/T 7714
Nagaya, K,Motomura, K,Kukk, E,et al. Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse[J]. PHYSICAL REVIEW X,2016,6(2):—.
APA Nagaya, K.,Motomura, K.,Kukk, E.,Fukuzawa, H.,Wada, S.,...&Nagaya, K .(2016).Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse.PHYSICAL REVIEW X,6(2),—.
MLA Nagaya, K,et al."Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse".PHYSICAL REVIEW X 6.2(2016):—.
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