Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting
Yin, XZ; Wu, L; Li, Y; Guo, T; Li, HY; Xiao, TQ; York, P; Nangia, A; Gui, SY; Zhang, JW; Zhang, JW (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China.; Zhang, JW (reprint author), Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China.; Zhang, JW (reprint author), Anhui Univ Chinese Med, Hefei 230038, Peoples R China.
2016
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号6期号:-页码:
文章类型期刊文献
摘要The deformation behavior of particles under pressure dominates the mechanical properties of solid dosage forms. In this study, the in situ 3D deformation of two polymorphs (I and II) of clopidogrel bisulfate (CLP) was determined to illustrate pressure distribution profiles within the tablet by the deformation of the crystalline particles for the first time. Synchrotron radiation X-ray computed microtomography (SR-mu CT) was utilized to visualize and quantify the morphology of thousands crystalline particles of CLP I and CLP II before and after compression. As a result, the deformation was examined across scale dimensions from microns to the size of the final dosage form. Three dimensional parameters such as volume, sphericity, oblate and prolate of individual particle and distributions were computed and analyzed for quantitative comparison to CLP I and CLP II. The different degrees of deformation under the same compression conditions of CLP I and CLP II were observed and characterized quantitatively. The map of deformation degrees within the tablet illustrated the heterogeneous pressure distribution in various regions of the compacted tablet. In conclusion, the polymorph deformation behaviors demonstrated by SR-p,CT quantitative structure analysis deepen understanding of tableting across dimensions from microns to millimeters for the macrostrcuture of tablet.
关键词X-ray Microtomography Controlled-release Kinetics Osmotic Pump Tablets Crystal-structure Density Distributions Mechanical-properties Compaction Properties Tomography
DOI10.1038/srep21770
收录类别SCI
语种英语
WOS记录号WOS:000370788500001
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/25890
专题中科院上海应用物理研究所2011-2018年
通讯作者Zhang, JW (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China.; Zhang, JW (reprint author), Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China.; Zhang, JW (reprint author), Anhui Univ Chinese Med, Hefei 230038, Peoples R China.
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Yin, XZ,Wu, L,Li, Y,et al. Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting[J]. SCIENTIFIC REPORTS,2016,6(-):—.
APA Yin, XZ.,Wu, L.,Li, Y.,Guo, T.,Li, HY.,...&Zhang, JW .(2016).Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting.SCIENTIFIC REPORTS,6(-),—.
MLA Yin, XZ,et al."Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting".SCIENTIFIC REPORTS 6.-(2016):—.
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