CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting
Yin, XZ; Wu, L; Li, Y; Guo, T; Li, HY; Xiao, TQ; York, P; Nangia, A; Gui, SY; Zhang, JW; Zhang, JW (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China.; Zhang, JW (reprint author), Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China.; Zhang, JW (reprint author), Anhui Univ Chinese Med, Hefei 230038, Peoples R China.
2016
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume6Issue:-Pages:
Subtype期刊文献
AbstractThe deformation behavior of particles under pressure dominates the mechanical properties of solid dosage forms. In this study, the in situ 3D deformation of two polymorphs (I and II) of clopidogrel bisulfate (CLP) was determined to illustrate pressure distribution profiles within the tablet by the deformation of the crystalline particles for the first time. Synchrotron radiation X-ray computed microtomography (SR-mu CT) was utilized to visualize and quantify the morphology of thousands crystalline particles of CLP I and CLP II before and after compression. As a result, the deformation was examined across scale dimensions from microns to the size of the final dosage form. Three dimensional parameters such as volume, sphericity, oblate and prolate of individual particle and distributions were computed and analyzed for quantitative comparison to CLP I and CLP II. The different degrees of deformation under the same compression conditions of CLP I and CLP II were observed and characterized quantitatively. The map of deformation degrees within the tablet illustrated the heterogeneous pressure distribution in various regions of the compacted tablet. In conclusion, the polymorph deformation behaviors demonstrated by SR-p,CT quantitative structure analysis deepen understanding of tableting across dimensions from microns to millimeters for the macrostrcuture of tablet.
KeywordX-ray Microtomography Controlled-release Kinetics Osmotic Pump Tablets Crystal-structure Density Distributions Mechanical-properties Compaction Properties Tomography
DOI10.1038/srep21770
Indexed BySCI
Language英语
WOS IDWOS:000370788500001
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25890
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorZhang, JW (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China.; Zhang, JW (reprint author), Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China.; Zhang, JW (reprint author), Anhui Univ Chinese Med, Hefei 230038, Peoples R China.
Recommended Citation
GB/T 7714
Yin, XZ,Wu, L,Li, Y,et al. Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting[J]. SCIENTIFIC REPORTS,2016,6(-):—.
APA Yin, XZ.,Wu, L.,Li, Y.,Guo, T.,Li, HY.,...&Zhang, JW .(2016).Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting.SCIENTIFIC REPORTS,6(-),—.
MLA Yin, XZ,et al."Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting".SCIENTIFIC REPORTS 6.-(2016):—.
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