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题名:
Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting
作者: Yin, XZ; Wu, L; Li, Y; Guo, T; Li, HY; Xiao, TQ; York, P; Nangia, A; Gui, SY; Zhang, JW
刊名: SCIENTIFIC REPORTS
出版日期: 2016
卷号: 6, 期号:-, 页码:
关键词: X-RAY MICROTOMOGRAPHY ; CONTROLLED-RELEASE KINETICS ; OSMOTIC PUMP TABLETS ; CRYSTAL-STRUCTURE ; DENSITY DISTRIBUTIONS ; MECHANICAL-PROPERTIES ; COMPACTION PROPERTIES ; TOMOGRAPHY
DOI: 10.1038/srep21770
通讯作者: Zhang, JW (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China. ; Zhang, JW (reprint author), Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China. ; Zhang, JW (reprint author), Anhui Univ Chinese Med, Hefei 230038, Peoples R China.
文章类型: 期刊文献
英文摘要: The deformation behavior of particles under pressure dominates the mechanical properties of solid dosage forms. In this study, the in situ 3D deformation of two polymorphs (I and II) of clopidogrel bisulfate (CLP) was determined to illustrate pressure distribution profiles within the tablet by the deformation of the crystalline particles for the first time. Synchrotron radiation X-ray computed microtomography (SR-mu CT) was utilized to visualize and quantify the morphology of thousands crystalline particles of CLP I and CLP II before and after compression. As a result, the deformation was examined across scale dimensions from microns to the size of the final dosage form. Three dimensional parameters such as volume, sphericity, oblate and prolate of individual particle and distributions were computed and analyzed for quantitative comparison to CLP I and CLP II. The different degrees of deformation under the same compression conditions of CLP I and CLP II were observed and characterized quantitatively. The map of deformation degrees within the tablet illustrated the heterogeneous pressure distribution in various regions of the compacted tablet. In conclusion, the polymorph deformation behaviors demonstrated by SR-p,CT quantitative structure analysis deepen understanding of tableting across dimensions from microns to millimeters for the macrostrcuture of tablet.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000370788500001
ISSN号: 2045-2322
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/25890
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Yin, XZ,Wu, L,Li, Y,et al. Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting[J]. SCIENTIFIC REPORTS,2016-01-01,6(-):—.
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文件名: Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting.pdf
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