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X-ray absorption near-edge structure study on the configuration of Cu2+/histidine complexes at different pH values
Yu, MJ; Wang, Y; Xu, W; Yu, MJ (reprint author), Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China.
2016
Source PublicationCHINESE PHYSICS B
ISSN1674-1056
Volume25Issue:4Pages:
Subtype期刊文献
AbstractThe local configurations around metal ions in metalloproteins are of great significance for understanding their biological functions. Cu2+/histidine (His) is a typical complex existing in many metalloproteins and plays an important role in lots of physiological functions. The three-dimensional (3D) structural configurations of Cu2+/His complexes at different pH values (2.5, 6.5, and 8.5) are quantitatively determined by x-ray absorption near-edge structure (XANES). Generally Cu2+/His complex keeps an octahedral configuration consisting of oxygen atoms from water molecules and oxygen or nitrogen atoms from histidine molecules coordinated around Cu2+. It is proved in this work that the oxygen atoms from water molecules, when increasing the pH value from acid to basic value, are gradually substituted by the O-carboxyl, N-am, and N-im from hisitidine molecules. Furthermore, the symmetries of Cu2+/His complexes at pH 6.5 and pH 8.5 are found to be lower than at pH 2.5.
KeywordExperimental Xanes Spectra Copper-histidine Therapy Menkes Disease Mxan Cu2++ Ni2++ Zn2++ Co2++
DOI10.1088/1674-1056/25/4/048701
Indexed BySCI
Language英语
WOS IDWOS:000375662600075
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25893
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorYu, MJ (reprint author), Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China.
Recommended Citation
GB/T 7714
Yu, MJ,Wang, Y,Xu, W,et al. X-ray absorption near-edge structure study on the configuration of Cu2+/histidine complexes at different pH values[J]. CHINESE PHYSICS B,2016,25(4):—.
APA Yu, MJ,Wang, Y,Xu, W,&Yu, MJ .(2016).X-ray absorption near-edge structure study on the configuration of Cu2+/histidine complexes at different pH values.CHINESE PHYSICS B,25(4),—.
MLA Yu, MJ,et al."X-ray absorption near-edge structure study on the configuration of Cu2+/histidine complexes at different pH values".CHINESE PHYSICS B 25.4(2016):—.
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