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题名:
X-ray absorption near-edge structure study on the configuration of Cu2+/histidine complexes at different pH values
作者: Yu, MJ; Wang, Y; Xu, W
刊名: CHINESE PHYSICS B
出版日期: 2016
卷号: 25, 期号:4, 页码:
关键词: EXPERIMENTAL XANES SPECTRA ; COPPER-HISTIDINE THERAPY ; MENKES DISEASE ; MXAN ; CU2+ ; NI2+ ; ZN2+ ; CO2+
DOI: 10.1088/1674-1056/25/4/048701
通讯作者: Yu, MJ (reprint author), Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China.
文章类型: 期刊文献
英文摘要: The local configurations around metal ions in metalloproteins are of great significance for understanding their biological functions. Cu2+/histidine (His) is a typical complex existing in many metalloproteins and plays an important role in lots of physiological functions. The three-dimensional (3D) structural configurations of Cu2+/His complexes at different pH values (2.5, 6.5, and 8.5) are quantitatively determined by x-ray absorption near-edge structure (XANES). Generally Cu2+/His complex keeps an octahedral configuration consisting of oxygen atoms from water molecules and oxygen or nitrogen atoms from histidine molecules coordinated around Cu2+. It is proved in this work that the oxygen atoms from water molecules, when increasing the pH value from acid to basic value, are gradually substituted by the O-carboxyl, N-am, and N-im from hisitidine molecules. Furthermore, the symmetries of Cu2+/His complexes at pH 6.5 and pH 8.5 are found to be lower than at pH 2.5.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000375662600075
ISSN号: 1674-1056
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/25893
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Yu, MJ,Wang, Y,Xu, W. X-ray absorption near-edge structure study on the configuration of Cu2+/histidine complexes at different pH values[J]. CHINESE PHYSICS B,2016-01-01,25(4):—.
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文件名: X-ray absorption near-edge structure study on the configuration of Cu2+histidine complexes at different pH values.pdf
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