A robust method for high-precision quantification of the complex three-dimensional vasculatures acquired by X-ray microtomography
Tan, H; Wang, DD; Li, RX; Sun, CM; Lagerstrom, R; He, Y; Xue, YL; Xiao, TQ; Xiao, TQ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201204, Peoples R China.; Xiao, TQ (reprint author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.; Wang, DD (reprint author), CSIRO Data61, Quantitat Imaging, Marsfield, NSW 2122, Australia.
2016
发表期刊JOURNAL OF SYNCHROTRON RADIATION
ISSN1600-5775
卷号23页码:1216-1226
文章类型期刊论文
摘要The quantification of micro-vasculatures is important for the analysis of angiogenesis on which the detection of tumor growth or hepatic fibrosis depends. Synchrotron-based X-ray computed micro-tomography (SR-mCT) allows rapid acquisition of micro-vasculature images at micrometer-scale spatial resolution. Through skeletonization, the statistical features of the micro-vasculature can be extracted from the skeleton of the micro-vasculatures. Thinning is a widely used algorithm to produce the vascular skeleton in medical research. Existing three-dimensional thinning methods normally emphasize the preservation of topological structure rather than geometrical features in generating the skeleton of a volumetric object. This results in three problems and limits the accuracy of the quantitative results related to the geometrical structure of the vasculature. The problems include the excessively shortened length of elongated objects, eliminated branches of blood vessel tree structure, and numerous noisy spurious branches. The inaccuracy of the skeleton directly introduces errors in the quantitative analysis, especially on the parameters concerning the vascular length and the counts of vessel segments and branching points. In this paper, a robust method using a consolidated end-point constraint for thinning, which generates geometry-preserving skeletons in addition to maintaining the topology of the vasculature, is presented. The improved skeleton can be used to produce more accurate quantitative results. Experimental results from high-resolution SR-mCT images show that the end-point constraint produced by the proposed method can significantly improve the accuracy of the skeleton obtained using the existing ITK three-dimensional thinning filter. The produced skeleton has laid the groundwork for accurate quantification of the angiogenesis. This is critical for the early detection of tumors and assessing anti-angiogenesis treatments.
关键词3d Image Analysis Quantitative Analysis Thinning End-point Skeleton Geometric Properties Vasculature
DOI10.1107/S1600577516011498
收录类别SCI
语种英语
WOS记录号WOS:000382299500023
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/26412
专题中科院上海应用物理研究所2011-2018年
通讯作者Xiao, TQ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201204, Peoples R China.; Xiao, TQ (reprint author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.; Wang, DD (reprint author), CSIRO Data61, Quantitat Imaging, Marsfield, NSW 2122, Australia.
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Tan, H,Wang, DD,Li, RX,et al. A robust method for high-precision quantification of the complex three-dimensional vasculatures acquired by X-ray microtomography[J]. JOURNAL OF SYNCHROTRON RADIATION,2016,23:1216-1226.
APA Tan, H.,Wang, DD.,Li, RX.,Sun, CM.,Lagerstrom, R.,...&Wang, DD .(2016).A robust method for high-precision quantification of the complex three-dimensional vasculatures acquired by X-ray microtomography.JOURNAL OF SYNCHROTRON RADIATION,23,1216-1226.
MLA Tan, H,et al."A robust method for high-precision quantification of the complex three-dimensional vasculatures acquired by X-ray microtomography".JOURNAL OF SYNCHROTRON RADIATION 23(2016):1216-1226.
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