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A robust method for high-precision quantification of the complex three-dimensional vasculatures acquired by X-ray microtomography
Tan, H; Wang, DD; Li, RX; Sun, CM; Lagerstrom, R; He, Y; Xue, YL; Xiao, TQ; Xiao, TQ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201204, Peoples R China.; Xiao, TQ (reprint author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.; Wang, DD (reprint author), CSIRO Data61, Quantitat Imaging, Marsfield, NSW 2122, Australia.
2016
Source PublicationJOURNAL OF SYNCHROTRON RADIATION
ISSN1600-5775
Volume23Pages:1216-1226
Subtype期刊论文
AbstractThe quantification of micro-vasculatures is important for the analysis of angiogenesis on which the detection of tumor growth or hepatic fibrosis depends. Synchrotron-based X-ray computed micro-tomography (SR-mCT) allows rapid acquisition of micro-vasculature images at micrometer-scale spatial resolution. Through skeletonization, the statistical features of the micro-vasculature can be extracted from the skeleton of the micro-vasculatures. Thinning is a widely used algorithm to produce the vascular skeleton in medical research. Existing three-dimensional thinning methods normally emphasize the preservation of topological structure rather than geometrical features in generating the skeleton of a volumetric object. This results in three problems and limits the accuracy of the quantitative results related to the geometrical structure of the vasculature. The problems include the excessively shortened length of elongated objects, eliminated branches of blood vessel tree structure, and numerous noisy spurious branches. The inaccuracy of the skeleton directly introduces errors in the quantitative analysis, especially on the parameters concerning the vascular length and the counts of vessel segments and branching points. In this paper, a robust method using a consolidated end-point constraint for thinning, which generates geometry-preserving skeletons in addition to maintaining the topology of the vasculature, is presented. The improved skeleton can be used to produce more accurate quantitative results. Experimental results from high-resolution SR-mCT images show that the end-point constraint produced by the proposed method can significantly improve the accuracy of the skeleton obtained using the existing ITK three-dimensional thinning filter. The produced skeleton has laid the groundwork for accurate quantification of the angiogenesis. This is critical for the early detection of tumors and assessing anti-angiogenesis treatments.
Keyword3d Image Analysis Quantitative Analysis Thinning End-point Skeleton Geometric Properties Vasculature
DOI10.1107/S1600577516011498
Indexed BySCI
Language英语
WOS IDWOS:000382299500023
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/26412
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorXiao, TQ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201204, Peoples R China.; Xiao, TQ (reprint author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.; Wang, DD (reprint author), CSIRO Data61, Quantitat Imaging, Marsfield, NSW 2122, Australia.
Recommended Citation
GB/T 7714
Tan, H,Wang, DD,Li, RX,et al. A robust method for high-precision quantification of the complex three-dimensional vasculatures acquired by X-ray microtomography[J]. JOURNAL OF SYNCHROTRON RADIATION,2016,23:1216-1226.
APA Tan, H.,Wang, DD.,Li, RX.,Sun, CM.,Lagerstrom, R.,...&Wang, DD .(2016).A robust method for high-precision quantification of the complex three-dimensional vasculatures acquired by X-ray microtomography.JOURNAL OF SYNCHROTRON RADIATION,23,1216-1226.
MLA Tan, H,et al."A robust method for high-precision quantification of the complex three-dimensional vasculatures acquired by X-ray microtomography".JOURNAL OF SYNCHROTRON RADIATION 23(2016):1216-1226.
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