Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures
Song, P; Li, M; Shen, JW; Pei, H; Chao, J; Su, S; Aldalbahi, A; Wang, LH; Shi, JY; Song, SP; Wang, LH; Fan, CH; Zuo, XL; Zuo, XL (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.; Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China.
2016
发表期刊ANALYTICAL CHEMISTRY
ISSN0003-2700
卷号88期号:16页码:8043-8049
文章类型期刊论文
摘要The fixed dynamic :range of traditional biosensors limits their utility in several real applications. For example, viral load monitoring requires the dynamic range spans Several orders of magnitude; whereas, monitoring of drugs requires extremely narrow dynamic range, To overcome this limitation; here, we devised tunable biosensing interface using allosteric DNA tetrahedral bioprobes to tune the dynamic range of DNA biosensors. Our strategy takes the advantage of the readily and flexible structure design, and predictable geometric Tecorifiguration of DNA nanotechtiology. We reconfigured the-DNA tetrahedral bioprobes by inserting the effector `sequence into the. DNA tetrahedron, through which, the binding affinity:of DNA tetrahedral bioprobes can be tuned. Asa result, the detection limit of DNA biosensors can be prograrrunably regulated. The,dynamic range of DNA biosensors can be tuned (narrowed: or extended) for up to 100-fold. Using the regulation of binding affinity, we realized the; capture and release of biomaecules by tuning the binding behavior of DNA tetrahedral bioprobes.
DOI10.1021/acs.analchem.6b01373
收录类别SCI
语种英语
WOS记录号WOS:000381654800024
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/26481
专题中科院上海应用物理研究所2011-2018年
通讯作者Zuo, XL (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.; Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China.
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Song, P,Li, M,Shen, JW,et al. Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures[J]. ANALYTICAL CHEMISTRY,2016,88(16):8043-8049.
APA Song, P.,Li, M.,Shen, JW.,Pei, H.,Chao, J.,...&Zuo, XL .(2016).Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures.ANALYTICAL CHEMISTRY,88(16),8043-8049.
MLA Song, P,et al."Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures".ANALYTICAL CHEMISTRY 88.16(2016):8043-8049.
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