CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures
Song, P; Li, M; Shen, JW; Pei, H; Chao, J; Su, S; Aldalbahi, A; Wang, LH; Shi, JY; Song, SP; Wang, LH; Fan, CH; Zuo, XL; Zuo, XL (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.; Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China.
2016
Source PublicationANALYTICAL CHEMISTRY
ISSN0003-2700
Volume88Issue:16Pages:8043-8049
Subtype期刊论文
AbstractThe fixed dynamic :range of traditional biosensors limits their utility in several real applications. For example, viral load monitoring requires the dynamic range spans Several orders of magnitude; whereas, monitoring of drugs requires extremely narrow dynamic range, To overcome this limitation; here, we devised tunable biosensing interface using allosteric DNA tetrahedral bioprobes to tune the dynamic range of DNA biosensors. Our strategy takes the advantage of the readily and flexible structure design, and predictable geometric Tecorifiguration of DNA nanotechtiology. We reconfigured the-DNA tetrahedral bioprobes by inserting the effector `sequence into the. DNA tetrahedron, through which, the binding affinity:of DNA tetrahedral bioprobes can be tuned. Asa result, the detection limit of DNA biosensors can be prograrrunably regulated. The,dynamic range of DNA biosensors can be tuned (narrowed: or extended) for up to 100-fold. Using the regulation of binding affinity, we realized the; capture and release of biomaecules by tuning the binding behavior of DNA tetrahedral bioprobes.
DOI10.1021/acs.analchem.6b01373
Indexed BySCI
Language英语
WOS IDWOS:000381654800024
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/26481
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorZuo, XL (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.; Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China.
Recommended Citation
GB/T 7714
Song, P,Li, M,Shen, JW,et al. Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures[J]. ANALYTICAL CHEMISTRY,2016,88(16):8043-8049.
APA Song, P.,Li, M.,Shen, JW.,Pei, H.,Chao, J.,...&Zuo, XL .(2016).Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures.ANALYTICAL CHEMISTRY,88(16),8043-8049.
MLA Song, P,et al."Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures".ANALYTICAL CHEMISTRY 88.16(2016):8043-8049.
Files in This Item:
File Name/Size DocType Version Access License
Dynamic Modulation o(2486KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Song, P]'s Articles
[Li, M]'s Articles
[Shen, JW]'s Articles
Baidu academic
Similar articles in Baidu academic
[Song, P]'s Articles
[Li, M]'s Articles
[Shen, JW]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Song, P]'s Articles
[Li, M]'s Articles
[Shen, JW]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.