Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures

doi:10.1021/acs.analchem.6b01373

CAS OpenIR > 中科院上海应用物理研究所2011-2020年

	Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures
	Song, P; Li, M; Shen, JW; Pei, H; Chao, J; Su, S; Aldalbahi, A; Wang, LH; Shi, JY; Song, SP; Wang, LH; Fan, CH; Zuo, XL; Zuo, XL (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.; Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China.
	2016
Source Publication	ANALYTICAL CHEMISTRY
ISSN	0003-2700
Volume	88 Issue:16 Pages:8043-8049
Subtype	期刊论文
Abstract	The fixed dynamic :range of traditional biosensors limits their utility in several real applications. For example, viral load monitoring requires the dynamic range spans Several orders of magnitude; whereas, monitoring of drugs requires extremely narrow dynamic range, To overcome this limitation; here, we devised tunable biosensing interface using allosteric DNA tetrahedral bioprobes to tune the dynamic range of DNA biosensors. Our strategy takes the advantage of the readily and flexible structure design, and predictable geometric Tecorifiguration of DNA nanotechtiology. We reconfigured the-DNA tetrahedral bioprobes by inserting the effector `sequence into the. DNA tetrahedron, through which, the binding affinity:of DNA tetrahedral bioprobes can be tuned. Asa result, the detection limit of DNA biosensors can be prograrrunably regulated. The,dynamic range of DNA biosensors can be tuned (narrowed: or extended) for up to 100-fold. Using the regulation of binding affinity, we realized the; capture and release of biomaecules by tuning the binding behavior of DNA tetrahedral bioprobes.
DOI	10.1021/acs.analchem.6b01373
Indexed By	SCI
Language	英语
WOS ID	WOS:000381654800024
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/26481
Collection	中科院上海应用物理研究所2011-2020年
Corresponding Author	Zuo, XL (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.; Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China.
Recommended Citation GB/T 7714	Song, P,Li, M,Shen, JW,et al. Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures[J]. ANALYTICAL CHEMISTRY,2016,88(16):8043-8049.
APA	Song, P.,Li, M.,Shen, JW.,Pei, H.,Chao, J.,...&Zuo, XL .(2016).Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures.ANALYTICAL CHEMISTRY,88(16),8043-8049.
MLA	Song, P,et al."Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures".ANALYTICAL CHEMISTRY 88.16(2016):8043-8049.

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