Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair
Wu, ZY; Zheng, K; Zhang, J; Tang, TT; Guo, H; Boccaccini, AR; Wei, J; Wei, J (reprint author), East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China.; Boccaccini, AR (reprint author), Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, Cauerstr 6, D-91058 Erlangen, Germany.
2016
发表期刊JOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
卷号4期号:48页码:7974-7988
文章类型期刊论文
摘要Bioactive scaffolds of magnesium silicate (m-MS)/poly(butylene succinate) (PBSu) composites were fabricated by a solvent casting particulate leaching method for bone regeneration. The scaffolds had a hierarchical porous structure with interconnected macropores (300-500 mu m), micropores (1-10 mu m) and mesopores (similar to 5 nm). In addition, the composite scaffolds were degradable in Tris-HCl solution and formed apatite on their surfaces in simulated body fluid, indicating good degradability and bioactivity in vitro. Compared with PBSu scaffolds, the composite scaffolds improved the in vitro attachment, proliferation and osteogenic differentiation of MC3T3-E1 cells, revealing good cytocompatibility. Furthermore, the model of rabbit femur cavity defects was used to evaluate the in vivo osteogenesis of the composite scaffolds. The results of synchrotron radiation-based mCT (SRmCT) imaging, histological analysis and immunohistochemistry showed that the composite scaffolds were gradually degraded and replaced by new bone, and the scaffolds with 40 wt% m-MS (C40) almost completely disappeared after 12 weeks of implantation, indicating that the scaffolds containing m-MS enhanced new bone formation. The results demonstrated that the bioactive m-MS/PBSu composite scaffolds with good biocompatibility, degradability, bioactivity and osteogenesis are promising biomaterials for bone repair.
DOI10.1039/c6tb02429g
收录类别SCI
语种英语
WOS记录号WOS:000391778200021
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/26492
专题中科院上海应用物理研究所2011-2018年
通讯作者Wei, J (reprint author), East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China.; Boccaccini, AR (reprint author), Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, Cauerstr 6, D-91058 Erlangen, Germany.
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Wu, ZY,Zheng, K,Zhang, J,et al. Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(48):7974-7988.
APA Wu, ZY.,Zheng, K.,Zhang, J.,Tang, TT.,Guo, H.,...&Boccaccini, AR .(2016).Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair.JOURNAL OF MATERIALS CHEMISTRY B,4(48),7974-7988.
MLA Wu, ZY,et al."Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair".JOURNAL OF MATERIALS CHEMISTRY B 4.48(2016):7974-7988.
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