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题名:
Enantioselective extraction extraction of phenylsuccinic acid in aqueous two-phase systems based on acetone and beta-cyclodextrin derivative: Modeling and optimization through response surface methodology
作者: Wang, J; Liu, Q; Rong, LY; Yang, H; Jiao, FP; Chen, XQ
刊名: JOURNAL OF CHROMATOGRAPHY A
出版日期: 2016
卷号: 1467, 页码:490-496
关键词: Aqueous two-phase system ; beta-CD derivative ; Enantioselective extraction ; Response surface methodology ; Inclusion complexation
DOI: 10.1016/j.chroma.2016.06.054
通讯作者: Chen, XQ (reprint author), Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.
文章类型: 期刊论文
英文摘要: A novel aqueous two-phase system (ATPS) composed beta-cyclodextrin (beta-CD) derivative and acetone was developed for enantioselective extraction of racemic phenylsuccinic acid (PSA). Binodal curves, tie-lines, and critical points for the investigated ATPS were determined and the experimental tie-lines data were successfully correlated by Othmer-Tobias, Bancroft, and Setschenow-type equations. ATPS containing sulfobutyl ether-beta-CD (SBE-beta-CD) exhibited better enantioselectivity than that using carboxymethyl-beta-CD (CM-beta-CD). To optimize enantioselective partitioning conditions of PSA in acetone/SBE-beta-CD ATPS, three factors (PSA concentration, pH, and equilibrium temperature) were analyzed by using central composite design in response surface methodology. The calculated equilibrium constants of inclusion complexation are 1638.64 M-1 for SBE-beta-CD-(R)-PSA and 835.84 M-1 for SBE-beta-CD-(S)-PSA, respectively. Under the optimized conditions, the separation factor of 3.14 and high enrichment efficiency (E-R = 98.06%, E-S =99.25%) were simultaneously achieved in a single step. (C) 2016 Elsevier B.V. All rights reserved.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000385323800048
ISSN号: 0021-9673
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/26494
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Wang, J,Liu, Q,Rong, LY,et al. Enantioselective extraction extraction of phenylsuccinic acid in aqueous two-phase systems based on acetone and beta-cyclodextrin derivative: Modeling and optimization through response surface methodology[J]. JOURNAL OF CHROMATOGRAPHY A,2016-01-01,1467:490-496.
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