Enantioselective extraction extraction of phenylsuccinic acid in aqueous two-phase systems based on acetone and beta-cyclodextrin derivative: Modeling and optimization through response surface methodology
Chen, XQ (reprint author), Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.
文章类型:
期刊论文
英文摘要:
A novel aqueous two-phase system (ATPS) composed beta-cyclodextrin (beta-CD) derivative and acetone was developed for enantioselective extraction of racemic phenylsuccinic acid (PSA). Binodal curves, tie-lines, and critical points for the investigated ATPS were determined and the experimental tie-lines data were successfully correlated by Othmer-Tobias, Bancroft, and Setschenow-type equations. ATPS containing sulfobutyl ether-beta-CD (SBE-beta-CD) exhibited better enantioselectivity than that using carboxymethyl-beta-CD (CM-beta-CD). To optimize enantioselective partitioning conditions of PSA in acetone/SBE-beta-CD ATPS, three factors (PSA concentration, pH, and equilibrium temperature) were analyzed by using central composite design in response surface methodology. The calculated equilibrium constants of inclusion complexation are 1638.64 M-1 for SBE-beta-CD-(R)-PSA and 835.84 M-1 for SBE-beta-CD-(S)-PSA, respectively. Under the optimized conditions, the separation factor of 3.14 and high enrichment efficiency (E-R = 98.06%, E-S =99.25%) were simultaneously achieved in a single step. (C) 2016 Elsevier B.V. All rights reserved.
Enantioselective extraction extraction of phenylsuccinic acid in aqueous two-phase systems based on acetone and beta-cyclodextrin derivative_ Modeling and....pdf（1441KB）
Enantioselective extraction extraction of phenylsuccinic acid in aqueous two-phase systems based on acetone and beta-cyclodextrin derivative_ Modeling and....pdf
