High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles

doi:10.1166/jnn.2016.11338

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles
	Ma, JF; Li, YL; Yu, BZ; Yu, BZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Dept Molten Salt Chem & Engn, Shanghai 201800, Peoples R China.
	2016
发表期刊	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN	1533-4880
卷号	16 期号:7 页码:7210-7214
文章类型	期刊论文
摘要	High molecular weight PEI (600 K) modified multiwalled carbon nanotubes (HMWPEI-MWCNTs) were studied in 293T cells as safe and efficient gene delivery vehicles. The HMWPEI-MWCNTs exhibited low cytotoxicity, and had enough ability to condense DNA and obviously enhance gene transfer activity. The concentration of HMWPEI-MWCNTs to 100 mu g/mL showed less effect on the 60% of cell viability, while the cell viability of HMWPEI was around 20% at the same concentration. The transfection efficiency of HMWPEI-MWCNTs was around 1.8 times, and much higher than those of naked DNA under an optimal nitrogen/phosphate (N/P) ratio of 10:1. The study demonstrates the possibility of developing the novel safe and efficient gene delivery systems by adopting low toxic and biocompatible nanocomposite.
关键词	Carbon Nanotubes Gene Delivery Polyethylenimine 293t Cells
DOI	10.1166/jnn.2016.11338
收录类别	SCI
语种	英语
WOS记录号	WOS:000387100400087
引用统计
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/26527
专题	中科院上海应用物理研究所2011-2018年
通讯作者	Yu, BZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Dept Molten Salt Chem & Engn, Shanghai 201800, Peoples R China.
推荐引用方式 GB/T 7714	Ma, JF,Li, YL,Yu, BZ,et al. High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(7):7210-7214.
APA	Ma, JF,Li, YL,Yu, BZ,&Yu, BZ .(2016).High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(7),7210-7214.
MLA	Ma, JF,et al."High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.7(2016):7210-7214.

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文件名称/大小	文献类型	版本类型	开放类型	使用许可
High Molecular Weigh（2766KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	请求全文