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题名: High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles
作者: Ma, JF; Li, YL; Yu, BZ
刊名: JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
出版日期: 2016
卷号: 16, 期号:7, 页码:7210-7214
关键词: Carbon Nanotubes ; Gene Delivery ; Polyethylenimine ; 293T Cells
DOI: 10.1166/jnn.2016.11338
通讯作者: Yu, BZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Dept Molten Salt Chem & Engn, Shanghai 201800, Peoples R China.
文章类型: 期刊论文
英文摘要: High molecular weight PEI (600 K) modified multiwalled carbon nanotubes (HMWPEI-MWCNTs) were studied in 293T cells as safe and efficient gene delivery vehicles. The HMWPEI-MWCNTs exhibited low cytotoxicity, and had enough ability to condense DNA and obviously enhance gene transfer activity. The concentration of HMWPEI-MWCNTs to 100 mu g/mL showed less effect on the 60% of cell viability, while the cell viability of HMWPEI was around 20% at the same concentration. The transfection efficiency of HMWPEI-MWCNTs was around 1.8 times, and much higher than those of naked DNA under an optimal nitrogen/phosphate (N/P) ratio of 10:1. The study demonstrates the possibility of developing the novel safe and efficient gene delivery systems by adopting low toxic and biocompatible nanocomposite.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000387100400087
ISSN号: 1533-4880
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/26527
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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