High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles
Ma, JF; Li, YL; Yu, BZ; Yu, BZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Dept Molten Salt Chem & Engn, Shanghai 201800, Peoples R China.
2016
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN1533-4880
卷号16期号:7页码:7210-7214
文章类型期刊论文
摘要High molecular weight PEI (600 K) modified multiwalled carbon nanotubes (HMWPEI-MWCNTs) were studied in 293T cells as safe and efficient gene delivery vehicles. The HMWPEI-MWCNTs exhibited low cytotoxicity, and had enough ability to condense DNA and obviously enhance gene transfer activity. The concentration of HMWPEI-MWCNTs to 100 mu g/mL showed less effect on the 60% of cell viability, while the cell viability of HMWPEI was around 20% at the same concentration. The transfection efficiency of HMWPEI-MWCNTs was around 1.8 times, and much higher than those of naked DNA under an optimal nitrogen/phosphate (N/P) ratio of 10:1. The study demonstrates the possibility of developing the novel safe and efficient gene delivery systems by adopting low toxic and biocompatible nanocomposite.
关键词Carbon Nanotubes Gene Delivery Polyethylenimine 293t Cells
DOI10.1166/jnn.2016.11338
收录类别SCI
语种英语
WOS记录号WOS:000387100400087
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/26527
专题中科院上海应用物理研究所2011-2018年
通讯作者Yu, BZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Dept Molten Salt Chem & Engn, Shanghai 201800, Peoples R China.
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Ma, JF,Li, YL,Yu, BZ,et al. High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(7):7210-7214.
APA Ma, JF,Li, YL,Yu, BZ,&Yu, BZ .(2016).High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(7),7210-7214.
MLA Ma, JF,et al."High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.7(2016):7210-7214.
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