Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles | |
| Ma, JF; Li, YL; Yu, BZ; Yu, BZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Dept Molten Salt Chem & Engn, Shanghai 201800, Peoples R China. | |
| 2016 | |
| Source Publication | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
 |
| ISSN | 1533-4880 |
| Volume | 16Issue:7Pages:7210-7214 |
| Subtype | 期刊论文 |
| Abstract | High molecular weight PEI (600 K) modified multiwalled carbon nanotubes (HMWPEI-MWCNTs) were studied in 293T cells as safe and efficient gene delivery vehicles. The HMWPEI-MWCNTs exhibited low cytotoxicity, and had enough ability to condense DNA and obviously enhance gene transfer activity. The concentration of HMWPEI-MWCNTs to 100 mu g/mL showed less effect on the 60% of cell viability, while the cell viability of HMWPEI was around 20% at the same concentration. The transfection efficiency of HMWPEI-MWCNTs was around 1.8 times, and much higher than those of naked DNA under an optimal nitrogen/phosphate (N/P) ratio of 10:1. The study demonstrates the possibility of developing the novel safe and efficient gene delivery systems by adopting low toxic and biocompatible nanocomposite. |
| Keyword | Carbon Nanotubes Gene Delivery Polyethylenimine 293t Cells |
| DOI | 10.1166/jnn.2016.11338 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000387100400087 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/26527 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Corresponding Author | Yu, BZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Dept Molten Salt Chem & Engn, Shanghai 201800, Peoples R China. |
| Recommended Citation GB/T 7714 | Ma, JF,Li, YL,Yu, BZ,et al. High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(7):7210-7214. |
| APA | Ma, JF,Li, YL,Yu, BZ,&Yu, BZ .(2016).High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(7),7210-7214. |
| MLA | Ma, JF,et al."High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.7(2016):7210-7214. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| High Molecular Weigh（2766KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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