Lab on smartphone with interfaced electrochemical chips for on-site gender verification
Deng, WP; Dou, YZ; Song, P; Xu, H; Aldalbahi, A; Chen, N; El-Sayed, NN; Gao, JM; Lu, JX; Song, SP; Zuo, XL; Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China.; Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China.; Gao, JM (reprint author), Wenzhou Med Univ, Sch Med Lab Sci & Life Sci, Wenzhou 325035, Peoples R China.
2016
发表期刊JOURNAL OF ELECTROANALYTICAL CHEMISTRY
ISSN1572-6657
卷号777页码:117-122
文章类型期刊论文
摘要On-site detection of biomarkers in biofluids found at the crime scene is critically important forensic analysis. However, it remains difficult due to the lack of portable, fast and cheap on-site analytical devices. Traditional methods including polymerase chain reaction (PCR) and electrophoresis requires complicated instrumentation and critical environment. Optical analytical methods can be affected by intrinsic adsorption of complicated sample such as serum. In response, we developed a smartphone-interfaced electrochemical chip device for on-site gender verification. The detection is based on the known difference of biomarkers (creatine kinase (CR) and alanine transaminase (ALT)) between male and female groups. Enzyme cascade reaction converted the enzyme level in biofluids to the consumption of NADH, which can be electrochemically detected by our designed electrochemical chip. Our device retained the capability of gender verification when used in serum and serum stains. The detection can be completed in 20 min. Gender verification of real samples (39 serum samples) demonstrated excellent sensitivity and specificity of this smartphone based device. (C) 2016 Elsevier B.V. All rights reserved.
关键词On Site detectiOn Electrochemical Biosensor Gender Verification Forensic
DOI10.1016/j.jelechem.2016.08.007
收录类别SCI
语种英语
WOS记录号WOS:000383298100015
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/26556
专题中科院上海应用物理研究所2011-2018年
通讯作者Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China.; Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China.; Gao, JM (reprint author), Wenzhou Med Univ, Sch Med Lab Sci & Life Sci, Wenzhou 325035, Peoples R China.
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GB/T 7714
Deng, WP,Dou, YZ,Song, P,et al. Lab on smartphone with interfaced electrochemical chips for on-site gender verification[J]. JOURNAL OF ELECTROANALYTICAL CHEMISTRY,2016,777:117-122.
APA Deng, WP.,Dou, YZ.,Song, P.,Xu, H.,Aldalbahi, A.,...&Gao, JM .(2016).Lab on smartphone with interfaced electrochemical chips for on-site gender verification.JOURNAL OF ELECTROANALYTICAL CHEMISTRY,777,117-122.
MLA Deng, WP,et al."Lab on smartphone with interfaced electrochemical chips for on-site gender verification".JOURNAL OF ELECTROANALYTICAL CHEMISTRY 777(2016):117-122.
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