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题名:
Lab on smartphone with interfaced electrochemical chips for on-site gender verification
作者: Deng, WP; Dou, YZ; Song, P; Xu, H; Aldalbahi, A; Chen, N; El-Sayed, NN; Gao, JM; Lu, JX; Song, SP; Zuo, XL
刊名: JOURNAL OF ELECTROANALYTICAL CHEMISTRY
出版日期: 2016
卷号: 777, 页码:117-122
关键词: On site detection ; Electrochemical ; Biosensor ; Gender verification ; Forensic
DOI: 10.1016/j.jelechem.2016.08.007
通讯作者: Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China. ; Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China. ; Gao, JM (reprint author), Wenzhou Med Univ, Sch Med Lab Sci & Life Sci, Wenzhou 325035, Peoples R China.
文章类型: 期刊论文
英文摘要: On-site detection of biomarkers in biofluids found at the crime scene is critically important forensic analysis. However, it remains difficult due to the lack of portable, fast and cheap on-site analytical devices. Traditional methods including polymerase chain reaction (PCR) and electrophoresis requires complicated instrumentation and critical environment. Optical analytical methods can be affected by intrinsic adsorption of complicated sample such as serum. In response, we developed a smartphone-interfaced electrochemical chip device for on-site gender verification. The detection is based on the known difference of biomarkers (creatine kinase (CR) and alanine transaminase (ALT)) between male and female groups. Enzyme cascade reaction converted the enzyme level in biofluids to the consumption of NADH, which can be electrochemically detected by our designed electrochemical chip. Our device retained the capability of gender verification when used in serum and serum stains. The detection can be completed in 20 min. Gender verification of real samples (39 serum samples) demonstrated excellent sensitivity and specificity of this smartphone based device. (C) 2016 Elsevier B.V. All rights reserved.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000383298100015
ISSN号: 1572-6657
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/26556
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Deng, WP,Dou, YZ,Song, P,et al. Lab on smartphone with interfaced electrochemical chips for on-site gender verification[J]. JOURNAL OF ELECTROANALYTICAL CHEMISTRY,2016-01-01,777:117-122.
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