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Lab on smartphone with interfaced electrochemical chips for on-site gender verification
Deng, WP; Dou, YZ; Song, P; Xu, H; Aldalbahi, A; Chen, N; El-Sayed, NN; Gao, JM; Lu, JX; Song, SP; Zuo, XL; Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China.; Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China.; Gao, JM (reprint author), Wenzhou Med Univ, Sch Med Lab Sci & Life Sci, Wenzhou 325035, Peoples R China.
2016
Source PublicationJOURNAL OF ELECTROANALYTICAL CHEMISTRY
ISSN1572-6657
Volume777Pages:117-122
Subtype期刊论文
AbstractOn-site detection of biomarkers in biofluids found at the crime scene is critically important forensic analysis. However, it remains difficult due to the lack of portable, fast and cheap on-site analytical devices. Traditional methods including polymerase chain reaction (PCR) and electrophoresis requires complicated instrumentation and critical environment. Optical analytical methods can be affected by intrinsic adsorption of complicated sample such as serum. In response, we developed a smartphone-interfaced electrochemical chip device for on-site gender verification. The detection is based on the known difference of biomarkers (creatine kinase (CR) and alanine transaminase (ALT)) between male and female groups. Enzyme cascade reaction converted the enzyme level in biofluids to the consumption of NADH, which can be electrochemically detected by our designed electrochemical chip. Our device retained the capability of gender verification when used in serum and serum stains. The detection can be completed in 20 min. Gender verification of real samples (39 serum samples) demonstrated excellent sensitivity and specificity of this smartphone based device. (C) 2016 Elsevier B.V. All rights reserved.
KeywordOn Site detectiOn Electrochemical Biosensor Gender Verification Forensic
DOI10.1016/j.jelechem.2016.08.007
Indexed BySCI
Language英语
WOS IDWOS:000383298100015
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/26556
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorZuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China.; Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China.; Gao, JM (reprint author), Wenzhou Med Univ, Sch Med Lab Sci & Life Sci, Wenzhou 325035, Peoples R China.
Recommended Citation
GB/T 7714
Deng, WP,Dou, YZ,Song, P,et al. Lab on smartphone with interfaced electrochemical chips for on-site gender verification[J]. JOURNAL OF ELECTROANALYTICAL CHEMISTRY,2016,777:117-122.
APA Deng, WP.,Dou, YZ.,Song, P.,Xu, H.,Aldalbahi, A.,...&Gao, JM .(2016).Lab on smartphone with interfaced electrochemical chips for on-site gender verification.JOURNAL OF ELECTROANALYTICAL CHEMISTRY,777,117-122.
MLA Deng, WP,et al."Lab on smartphone with interfaced electrochemical chips for on-site gender verification".JOURNAL OF ELECTROANALYTICAL CHEMISTRY 777(2016):117-122.
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