中国科学院上海应用物理研究所机构知识库
Advanced  
CAS OpenIR  > 中科院上海应用物理研究所2011-2017年  > 期刊论文
题名: Lanthanide (Gd3+ and Yb3+) functionalized gold nanoparticles for in vivo imaging and therapy
作者: Ge, XQ; Song, ZM; Sun, LN; Yang, YF; Shi, LY; Si, R; Ren, W; Qiu, X; Wang, HF
刊名: BIOMATERIALS
出版日期: 2016
卷号: 108, 页码:35-43
关键词: Gold ; Lanthanide ; Magnetic resonance imaging (MRI) ; Computed tomography (CT) imaging ; Photothermal therapy (PTT)
DOI: 10.1016/j.biomaterials.2016.08.051
通讯作者: Sun, LN (reprint author), Shanghai Univ, Res Ctr Nano Sci & Technol, Shanghai 200444, Peoples R China. ; Sun, LN (reprint author), Shanghai Univ, Sch Mat Sci & Engn, Shanghai 200444, Peoples R China. ; Wang, HF (reprint author), Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China.
文章类型: 期刊论文
英文摘要: Nanoparticles are regularly used as contrast agents in bioimaging. Unlike other agents such as composite materials, nanoparticles can also be used for treating as well as imaging disease. Here we synthesized lanthanide functionalized gold nanoparticles that can be used for both imaging and therapy in vivo. That is a multifunctional nanoplatform was developed based on a simple and versatile method, by incorporating 10-nm gold nanoparticles and lanthanide ions (Gd3+ and Yb3+), denoted as LnAu nanoparticles hereby. The LnAu nanoparticles were then surface-modified using a PEGylated amphiphilic polymer (C18MH-mPEG), and the resulting PEG modified LnAu nanoparticles (PEG-LnAu) display good mono dispersion in water and good solubility in biological media. Due to the low toxicity in vitro and in vivo (as determined by a cell viability assay and histological and serum biochemistry analysis), the PEG-LnAu nanoparticles can be successfully applied to in vivo magnetic resonance imaging (MRI), in vivo computed tomography (Cr) imaging and photothermal therapy (PIT) for tumor-bearing mice. Therefore, the present work developed an easy yet powerful strategy to combine lanthanide ions and gold nano particles to a unified nanoplatform for integrating bioimaging and therapy. (C) 2016 Elsevier Ltd. All rights reserved.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000384860100003
ISSN号: 0142-9612
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/26558
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Lanthanide (Gd3+ and Yb3+) functionalized gold nanoparticles for in vivo imaging and therapy.pdf(2624KB)期刊论文作者接受稿开放获取View Download
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ge, XQ]'s Articles
[Song, ZM]'s Articles
[Sun, LN]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ge, XQ]‘s Articles
[Song, ZM]‘s Articles
[Sun, LN]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Lanthanide (Gd3+ and Yb3+) functionalized gold nanoparticles for in vivo imaging and therapy.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace