Sun, LN (reprint author), Shanghai Univ, Res Ctr Nano Sci & Technol, Shanghai 200444, Peoples R China.
; Sun, LN (reprint author), Shanghai Univ, Sch Mat Sci & Engn, Shanghai 200444, Peoples R China.
; Wang, HF (reprint author), Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China.
文章类型:
期刊论文
英文摘要:
Nanoparticles are regularly used as contrast agents in bioimaging. Unlike other agents such as composite materials, nanoparticles can also be used for treating as well as imaging disease. Here we synthesized lanthanide functionalized gold nanoparticles that can be used for both imaging and therapy in vivo. That is a multifunctional nanoplatform was developed based on a simple and versatile method, by incorporating 10-nm gold nanoparticles and lanthanide ions (Gd3+ and Yb3+), denoted as LnAu nanoparticles hereby. The LnAu nanoparticles were then surface-modified using a PEGylated amphiphilic polymer (C18MH-mPEG), and the resulting PEG modified LnAu nanoparticles (PEG-LnAu) display good mono dispersion in water and good solubility in biological media. Due to the low toxicity in vitro and in vivo (as determined by a cell viability assay and histological and serum biochemistry analysis), the PEG-LnAu nanoparticles can be successfully applied to in vivo magnetic resonance imaging (MRI), in vivo computed tomography (Cr) imaging and photothermal therapy (PIT) for tumor-bearing mice. Therefore, the present work developed an easy yet powerful strategy to combine lanthanide ions and gold nano particles to a unified nanoplatform for integrating bioimaging and therapy. (C) 2016 Elsevier Ltd. All rights reserved.
