Linking Subcellular Disturbance to Physiological Behavior and Toxicity Induced by Quantum Dots in Caenorhabditis elegans
Wang, Q; Zhou, YF; Song, B; Zhong, YL; Wu, SC; Cui, RR; Cong, HX; Su, YY; Zhang, HM; He, Y; He, Y (reprint author), Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China.; Zhang, HM (reprint author), Soochow Univ, IBMS, Suzhou 215123, Peoples R China.
2016
发表期刊SMALL
ISSN1613-6810
卷号12期号:23页码:3143-3154
文章类型期刊论文
摘要The wide-ranging applications of fluorescent semiconductor quantum dots (QDs) have triggered increasing concerns about their biosafety. Most QD-related toxicity studies focus on the subcellular processes in cultured cells or global physiological effects on whole animals. However, it is unclear how QDs affect subcellular processes in living organisms, or how the subcellular disturbance contributes to the overall toxicity. Here the behavior and toxicity of QDs of three different sizes in Caenorhabditis elegans (C. elegans) are systematically investigated at both the systemic and the subcellular level. Specifically, clear size-dependent distribution and toxicity of the QDs in the digestive tract are observed. Short-term exposure of QDs leads to acute toxicity on C. elegans, yet incurring no lasting, irreversible damage. In contrast, chronic exposure of QDs severely inhibits development and shortens lifespan. Subcellular analysis reveals that endocytosis and nutrition storage are disrupted by QDs, which likely accounts for the severe deterioration in growth and longevity. This work reveals that QDs invasion disrupts key subcellular processes in living organisms, and may cause permanent damage to the tissues and organs over long-term retention. The findings provide invaluable information for safety evaluations of QD-based applications and offer new opportunities for design of novel nontoxic nanoprobes.
DOI10.1002/smll.201600766
收录类别SCI
语种英语
WOS记录号WOS:000378654700009
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/26561
专题中科院上海应用物理研究所2011-2018年
通讯作者He, Y (reprint author), Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China.; Zhang, HM (reprint author), Soochow Univ, IBMS, Suzhou 215123, Peoples R China.
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Wang, Q,Zhou, YF,Song, B,et al. Linking Subcellular Disturbance to Physiological Behavior and Toxicity Induced by Quantum Dots in Caenorhabditis elegans[J]. SMALL,2016,12(23):3143-3154.
APA Wang, Q.,Zhou, YF.,Song, B.,Zhong, YL.,Wu, SC.,...&Zhang, HM .(2016).Linking Subcellular Disturbance to Physiological Behavior and Toxicity Induced by Quantum Dots in Caenorhabditis elegans.SMALL,12(23),3143-3154.
MLA Wang, Q,et al."Linking Subcellular Disturbance to Physiological Behavior and Toxicity Induced by Quantum Dots in Caenorhabditis elegans".SMALL 12.23(2016):3143-3154.
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