CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Linking Subcellular Disturbance to Physiological Behavior and Toxicity Induced by Quantum Dots in Caenorhabditis elegans
Wang, Q; Zhou, YF; Song, B; Zhong, YL; Wu, SC; Cui, RR; Cong, HX; Su, YY; Zhang, HM; He, Y; He, Y (reprint author), Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China.; Zhang, HM (reprint author), Soochow Univ, IBMS, Suzhou 215123, Peoples R China.
2016
Source PublicationSMALL
ISSN1613-6810
Volume12Issue:23Pages:3143-3154
Subtype期刊论文
AbstractThe wide-ranging applications of fluorescent semiconductor quantum dots (QDs) have triggered increasing concerns about their biosafety. Most QD-related toxicity studies focus on the subcellular processes in cultured cells or global physiological effects on whole animals. However, it is unclear how QDs affect subcellular processes in living organisms, or how the subcellular disturbance contributes to the overall toxicity. Here the behavior and toxicity of QDs of three different sizes in Caenorhabditis elegans (C. elegans) are systematically investigated at both the systemic and the subcellular level. Specifically, clear size-dependent distribution and toxicity of the QDs in the digestive tract are observed. Short-term exposure of QDs leads to acute toxicity on C. elegans, yet incurring no lasting, irreversible damage. In contrast, chronic exposure of QDs severely inhibits development and shortens lifespan. Subcellular analysis reveals that endocytosis and nutrition storage are disrupted by QDs, which likely accounts for the severe deterioration in growth and longevity. This work reveals that QDs invasion disrupts key subcellular processes in living organisms, and may cause permanent damage to the tissues and organs over long-term retention. The findings provide invaluable information for safety evaluations of QD-based applications and offer new opportunities for design of novel nontoxic nanoprobes.
DOI10.1002/smll.201600766
Indexed BySCI
Language英语
WOS IDWOS:000378654700009
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/26561
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorHe, Y (reprint author), Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China.; Zhang, HM (reprint author), Soochow Univ, IBMS, Suzhou 215123, Peoples R China.
Recommended Citation
GB/T 7714
Wang, Q,Zhou, YF,Song, B,et al. Linking Subcellular Disturbance to Physiological Behavior and Toxicity Induced by Quantum Dots in Caenorhabditis elegans[J]. SMALL,2016,12(23):3143-3154.
APA Wang, Q.,Zhou, YF.,Song, B.,Zhong, YL.,Wu, SC.,...&Zhang, HM .(2016).Linking Subcellular Disturbance to Physiological Behavior and Toxicity Induced by Quantum Dots in Caenorhabditis elegans.SMALL,12(23),3143-3154.
MLA Wang, Q,et al."Linking Subcellular Disturbance to Physiological Behavior and Toxicity Induced by Quantum Dots in Caenorhabditis elegans".SMALL 12.23(2016):3143-3154.
Files in This Item:
File Name/Size DocType Version Access License
Linking Subcellular (11621KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Q]'s Articles
[Zhou, YF]'s Articles
[Song, B]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Q]'s Articles
[Zhou, YF]'s Articles
[Song, B]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Q]'s Articles
[Zhou, YF]'s Articles
[Song, B]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Linking Subcellular Disturbance to Physiological Behavior and Toxicity Induced by Quantum Dots in Caenorhabditis elegans.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.