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On-Electrode Synthesis of Shape-Controlled Hierarchical Flower-Like Gold Nanostructures for Efficient Interfacial DNA Assembly and Sensitive Electrochemical Sensing of MicroRNA
Su, S; Wu, Y; Zhu, D; Chao, J; Liu, XF; Wan, Y; Su, Y; Zuo, XL; Fan, CH; Wang, LH; Wang, LH (reprint author), Nanjing Univ Posts & Telecommun, KLOEID, IAM, Natl Synergist Innovat Ctr Adv Mat SICAM, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China.; Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China.
2016
Source PublicationSMALL
ISSN1613-6810
Volume12Issue:28Pages:3794-3801
Subtype期刊论文
AbstractThe performance for biomolecular detection is closely associated with the interfacial structure of a biosensor, which profoundly affects both thermodynamics and kinetics of the assembly, binding and signal transduction of biomolecules. Herein, it is reported on a one-step and template-free on-electrode synthesis method for making shape-controlled gold nanostructures on indium tin oxide substrates, which provide an electrochemical sensing platform for ultrasensitive detection of nucleic acids. Thus-prepared hierarchical flower-like gold nanostructures (HFGNs) possess large surface area that can readily accommodate the assembly of DNA probes for subsequent hybridization detection. It is found that the sensitivity for electrochemical DNA sensing is critically dependent on the morphology of HFGNs. By using this new strategy, a highly sensitive electrochemical biosensor is developed for label-free detection of microRNA-21 (miRNA-21), a biomarker for lung cancers. Importantly, it is demonstrated that this biosensor can be employed to measure the miRNA-21 expression level from human lung cancer cell (A549) lysates and worked well in 100% serum, suggesting its potential for applications in clinical diagnosis and a wide range of bioanalysis.
DOI10.1002/smll.201601066
Indexed BySCI
Language英语
WOS IDWOS:000383375100008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/26590
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorFan, CH; Wang, LH (reprint author), Nanjing Univ Posts & Telecommun, KLOEID, IAM, Natl Synergist Innovat Ctr Adv Mat SICAM, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China.; Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China.
Recommended Citation
GB/T 7714
Su, S,Wu, Y,Zhu, D,et al. On-Electrode Synthesis of Shape-Controlled Hierarchical Flower-Like Gold Nanostructures for Efficient Interfacial DNA Assembly and Sensitive Electrochemical Sensing of MicroRNA[J]. SMALL,2016,12(28):3794-3801.
APA Su, S.,Wu, Y.,Zhu, D.,Chao, J.,Liu, XF.,...&Fan, CH .(2016).On-Electrode Synthesis of Shape-Controlled Hierarchical Flower-Like Gold Nanostructures for Efficient Interfacial DNA Assembly and Sensitive Electrochemical Sensing of MicroRNA.SMALL,12(28),3794-3801.
MLA Su, S,et al."On-Electrode Synthesis of Shape-Controlled Hierarchical Flower-Like Gold Nanostructures for Efficient Interfacial DNA Assembly and Sensitive Electrochemical Sensing of MicroRNA".SMALL 12.28(2016):3794-3801.
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