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题名: Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction
作者: Wang, L; Li, XM; Han, YP; Wang, T; Zhao, Y; Ali, A; El-Sayed, NN; Shi, JY; Wang, WF; Fan, CH; Chen, N
刊名: SCIENCE CHINA-CHEMISTRY
出版日期: 2016
卷号: 59, 期号:11, 页码:1486-1491
关键词: quantum dots ; autophagy ; Parkinson's disease ; alpha-Synuclein ; Beclin1
DOI: 10.1007/s11426-016-0103-7
通讯作者: Chen, N (reprint author), Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Div Phys Biol,Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China. ; Chen, N (reprint author), Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China. ; Zhao, Y (reprint author), Sichuan Univ, Sch Life Sci, Chengdu 610064, Peoples R China.
文章类型: 期刊论文
英文摘要: Autophagy is a basic cellular process that decomposes damaged organelles and aberrant proteins. Dysregulation of autophagy is implicated in pathogenesis of neurodegenerative disorders, including Parkinson's disease (PD). Pharmacological compounds that stimulate autophagy can provide neuroprotection in models of PD. Nanoparticles have emerged as regulators of autophagy and have been tested in adjuvant therapy for diseases. In this present study, we explore the effects of quantum dots (QDs) that can induce autophagy in a cellular model of Parkinson's disease. CdTe/CdS/ZnS QDs protect differentiated rat pheochromocytoma PC12 cells from MPP+-induced cell damage, including reduced viability, apoptosis and accumulation of alpha-Synuclein, a characteristic protein of PD. The protective function of QDs is autophagy-dependent. In addition, we investigate the interaction between quantum dots and autophagic pathways and identify beclin1 as an essential factor for QDs-induced autophagy. Our results reveal new promise of QDs in the theranostic of neurodegenerative diseases.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000387571100016
ISSN号: 1674-7291
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/26611
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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