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Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction
Wang, L; Li, XM; Han, YP; Wang, T; Zhao, Y; Ali, A; El-Sayed, NN; Shi, JY; Wang, WF; Fan, CH; Chen, N; Chen, N (reprint author), Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Div Phys Biol,Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.; Chen, N (reprint author), Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.; Zhao, Y (reprint author), Sichuan Univ, Sch Life Sci, Chengdu 610064, Peoples R China.
2016
Source PublicationSCIENCE CHINA-CHEMISTRY
ISSN1674-7291
Volume59Issue:11Pages:1486-1491
Subtype期刊论文
AbstractAutophagy is a basic cellular process that decomposes damaged organelles and aberrant proteins. Dysregulation of autophagy is implicated in pathogenesis of neurodegenerative disorders, including Parkinson's disease (PD). Pharmacological compounds that stimulate autophagy can provide neuroprotection in models of PD. Nanoparticles have emerged as regulators of autophagy and have been tested in adjuvant therapy for diseases. In this present study, we explore the effects of quantum dots (QDs) that can induce autophagy in a cellular model of Parkinson's disease. CdTe/CdS/ZnS QDs protect differentiated rat pheochromocytoma PC12 cells from MPP+-induced cell damage, including reduced viability, apoptosis and accumulation of alpha-Synuclein, a characteristic protein of PD. The protective function of QDs is autophagy-dependent. In addition, we investigate the interaction between quantum dots and autophagic pathways and identify beclin1 as an essential factor for QDs-induced autophagy. Our results reveal new promise of QDs in the theranostic of neurodegenerative diseases.
KeywordQuantum Dots Autophagy Parkinson's Disease Alpha-synuclein Beclin1
DOI10.1007/s11426-016-0103-7
Indexed BySCI
Language英语
WOS IDWOS:000387571100016
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/26611
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorChen, N (reprint author), Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Div Phys Biol,Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.; Chen, N (reprint author), Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.; Zhao, Y (reprint author), Sichuan Univ, Sch Life Sci, Chengdu 610064, Peoples R China.
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GB/T 7714
Wang, L,Li, XM,Han, YP,et al. Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction[J]. SCIENCE CHINA-CHEMISTRY,2016,59(11):1486-1491.
APA Wang, L.,Li, XM.,Han, YP.,Wang, T.,Zhao, Y.,...&Zhao, Y .(2016).Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction.SCIENCE CHINA-CHEMISTRY,59(11),1486-1491.
MLA Wang, L,et al."Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction".SCIENCE CHINA-CHEMISTRY 59.11(2016):1486-1491.
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