Li, D (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.
文章类型:
期刊论文
英文摘要:
It is traditionally assumed that enzymatic reaction does not perturb the diffusion of an enzyme itself. Recent studies showed that the diffusivity of enzymes increased in a substrate-dependent manner during catalysis. Thus, the energy released during enzyme catalysis could be used to propel nanoscale objects, e.g. molecule motors driven by enzymatic reactions. Although the dependence of enzyme diffusion on substrate has been reported in several different enzyme systems, the exact origin of this phenomenon is still unknown yet. However, several possible mechanisms were proposed for the enhanced diffusion. This review illustrates recent progress in the research on the influence of enzymatic reaction on the diffusivity of enzymes, including the change of diffusion coefficient of enzymes, potential mechanisms and related applications.
