Silica Nanoparticles Target a Wnt Signal Transducer for Degradation and Impair Embryonic Development in Zebrafish
Yi, HY; Wang, ZY; Li, XJ; Yin, M; Wang, LH; Aldalbahi, A; El-Sayed, NN; Wang, H; Chen, N; Fan, CH; Song, HY; Song, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai 200031, Peoples R China.; Song, HY (reprint author), Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China.; Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China.; Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai Synchrotron Radiat Facil,Bioimaging Ctr, Shanghai 201800, Peoples R China.
2016
发表期刊THERANOSTICS
ISSN1838-7640
卷号6期号:11页码:1810-1820
文章类型期刊论文
摘要Many types of biocompatible nanomaterials have proven of low cytotoxicity and hold great promise for various applications in nanomedicine. Whereas they generally do not cause apparent organ toxicity or tissue damage in adult animals, it is yet to determine their biological consequences in more general contexts. In this study, we investigate how silica nanoparticles (NPs) affect cellular activities and functions under several physiological or pathological conditions. Although silica NPs are generally regarded as "inert" nanocarriers and widely employed in biomedical studies, we find that they actively affect Wnt signaling in various types of cell lines, diminishing its anti-adipogenic effect in preadipocytes and pro-invasive effect in breast cancer cells, and more significantly, impair Wnt-regulated embryonic development in Zebrafish. We further demonstrate that intracellular silica NPs block Wnt signal transduction in a way resembling signaling molecules. Specifically, silica NPs target the Dvl protein, a key component of Wnt signaling cascade, for lysosomal degradation. As Wnt signaling play significant roles in embryonic development and adipogenesis, the observed physiological effects beyond toxicity imply potential risk of obesity, or developmental defects in somitogenesis and osteogenesis upon exposure to silica NPs. In addition, given the clinical implications of Wnt signaling in tumorigenesis and cancer metastasis, our work also establishes for the first time a molecular link between nanomaterials and the Wnt signaling pathway, which opens new door for novel applications of unmodified silica NPs in targeted therapy for cancers and other critical illness.
关键词Silica Nanoparticles Signal Transduction Embryonic Development Obesity Cancer Metastasis
DOI10.7150/thno.16127
收录类别SCI
语种英语
WOS记录号WOS:000384108900006
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/26622
专题中科院上海应用物理研究所2011-2018年
通讯作者Chen, N; Song, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai 200031, Peoples R China.; Song, HY (reprint author), Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China.; Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China.; Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai Synchrotron Radiat Facil,Bioimaging Ctr, Shanghai 201800, Peoples R China.
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Yi, HY,Wang, ZY,Li, XJ,et al. Silica Nanoparticles Target a Wnt Signal Transducer for Degradation and Impair Embryonic Development in Zebrafish[J]. THERANOSTICS,2016,6(11):1810-1820.
APA Yi, HY.,Wang, ZY.,Li, XJ.,Yin, M.,Wang, LH.,...&Fan, CH .(2016).Silica Nanoparticles Target a Wnt Signal Transducer for Degradation and Impair Embryonic Development in Zebrafish.THERANOSTICS,6(11),1810-1820.
MLA Yi, HY,et al."Silica Nanoparticles Target a Wnt Signal Transducer for Degradation and Impair Embryonic Development in Zebrafish".THERANOSTICS 6.11(2016):1810-1820.
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