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题名:
Single-pulse enhanced coherent diffraction imaging of bacteria with an X-ray free-electron laser
作者: Fan, JD; Sun, ZB; Wang, YL; Park, J; Kim, S; Gallagher-Jones, M; Kim, Y; Song, CY; Yao, S; Zhang, J; Zhang, JH; Duan, XL; Tono, K; Yabashi, M; Ishikawa, T; Fan, CH; Zhao, YL; Chai, ZF; Gao, XY; Earnest, T; Jiang, HD
刊名: SCIENTIFIC REPORTS
出版日期: 2016
卷号: 6, 页码:-
DOI: 10.1038/srep34008
通讯作者: Jiang, HD (reprint author), Shandong Univ, State Key Lab Crystal Mat, Jinan 250100, Peoples R China. ; Gao, XY (reprint author), Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China. ; Jiang, HD (reprint author), Shanghai Tech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China.
文章类型: 期刊论文
英文摘要: High-resolution imaging offers one of the most promising approaches for exploring and understanding the structure and function of biomaterials and biological systems. X-ray free-electron lasers (XFELs) combined with coherent diffraction imaging can theoretically provide high-resolution spatial information regarding biological materials using a single XFEL pulse. Currently, the application of this method suffers from the low scattering cross-section of biomaterials and X-ray damage to the sample. However, XFELs can provide pulses of such short duration that the data can be collected using the "diffract and destroy" approach before the effects of radiation damage on the data become significant. These experiments combine the use of enhanced coherent diffraction imaging with single-shot XFEL radiation to investigate the cellular architecture of Staphylococcus aureus with and without labeling by gold (Au) nanoclusters. The resolution of the images reconstructed from these diffraction patterns were twice as high or more for gold-labeled samples, demonstrating that this enhancement method provides a promising approach for the high-resolution imaging of biomaterials and biological systems.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000384045500001
ISSN号: 2045-2322
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/26624
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Fan, JD,Sun, ZB,Wang, YL,et al. Single-pulse enhanced coherent diffraction imaging of bacteria with an X-ray free-electron laser[J]. SCIENTIFIC REPORTS,2016-01-01,6:-.
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