Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease
Zheng, L; Zhu, HZ; Wang, BT; Zhao, QH; Du, XB; Zheng, Y; Jiang, L; Ni, JZ; Zhang, Y; Liu, Q; Liu, Q (reprint author), Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen 518060, Guangdong, Peoples R China.; Zhang, Y (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China.
2016
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号6页码:-
文章类型期刊论文
摘要Many studies have shown that imbalance of mineral metabolism may play an important role in Alzheimer's disease (AD) progression. It was recently reported that selenium could reverse memory deficits in AD mouse model. We carried out multi-time-point ionome analysis to investigate the interactions among 15 elements in the brain by using a triple-transgenic mouse model of AD with/without high-dose sodium selenate supplementation. Except selenium, the majority of significantly changed elements showed a reduced level after 6-month selenate supplementation, especially iron whose levels were completely reversed to normal state at almost all examined time points. We then built the elemental correlation network for each time point. Significant and specific elemental correlations and correlation changes were identified, implying a highly complex and dynamic crosstalk between selenium and other elements during long-term supplementation with selenate. Finally, we measured the activities of two important anti-oxidative selenoenzymes, glutathione peroxidase and thioredoxin reductase, and found that they were remarkably increased in the cerebrum of selenate-treated mice, suggesting that selenoenzyme-mediated protection against oxidative stress might also be involved in the therapeutic effect of selenate in AD. Overall, this study should contribute to our understanding of the mechanism related to the potential use of selenate in AD treatment.
DOI10.1038/srep39290
收录类别SCI
语种英语
WOS记录号WOS:000390374200001
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/26626
专题中科院上海应用物理研究所2011-2018年
通讯作者Zhang, Y; Liu, Q (reprint author), Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen 518060, Guangdong, Peoples R China.; Zhang, Y (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China.
推荐引用方式
GB/T 7714
Zheng, L,Zhu, HZ,Wang, BT,et al. Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease[J]. SCIENTIFIC REPORTS,2016,6:-.
APA Zheng, L.,Zhu, HZ.,Wang, BT.,Zhao, QH.,Du, XB.,...&Zhang, Y .(2016).Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease.SCIENTIFIC REPORTS,6,-.
MLA Zheng, L,et al."Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease".SCIENTIFIC REPORTS 6(2016):-.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Sodium selenate regu(2158KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zheng, L]的文章
[Zhu, HZ]的文章
[Wang, BT]的文章
百度学术
百度学术中相似的文章
[Zheng, L]的文章
[Zhu, HZ]的文章
[Wang, BT]的文章
必应学术
必应学术中相似的文章
[Zheng, L]的文章
[Zhu, HZ]的文章
[Wang, BT]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。