CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease
Zheng, L; Zhu, HZ; Wang, BT; Zhao, QH; Du, XB; Zheng, Y; Jiang, L; Ni, JZ; Zhang, Y; Liu, Q; Liu, Q (reprint author), Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen 518060, Guangdong, Peoples R China.; Zhang, Y (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China.
2016
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume6Pages:-
Subtype期刊论文
AbstractMany studies have shown that imbalance of mineral metabolism may play an important role in Alzheimer's disease (AD) progression. It was recently reported that selenium could reverse memory deficits in AD mouse model. We carried out multi-time-point ionome analysis to investigate the interactions among 15 elements in the brain by using a triple-transgenic mouse model of AD with/without high-dose sodium selenate supplementation. Except selenium, the majority of significantly changed elements showed a reduced level after 6-month selenate supplementation, especially iron whose levels were completely reversed to normal state at almost all examined time points. We then built the elemental correlation network for each time point. Significant and specific elemental correlations and correlation changes were identified, implying a highly complex and dynamic crosstalk between selenium and other elements during long-term supplementation with selenate. Finally, we measured the activities of two important anti-oxidative selenoenzymes, glutathione peroxidase and thioredoxin reductase, and found that they were remarkably increased in the cerebrum of selenate-treated mice, suggesting that selenoenzyme-mediated protection against oxidative stress might also be involved in the therapeutic effect of selenate in AD. Overall, this study should contribute to our understanding of the mechanism related to the potential use of selenate in AD treatment.
DOI10.1038/srep39290
Indexed BySCI
Language英语
WOS IDWOS:000390374200001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/26626
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorZhang, Y; Liu, Q (reprint author), Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen 518060, Guangdong, Peoples R China.; Zhang, Y (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China.
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GB/T 7714
Zheng, L,Zhu, HZ,Wang, BT,et al. Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease[J]. SCIENTIFIC REPORTS,2016,6:-.
APA Zheng, L.,Zhu, HZ.,Wang, BT.,Zhao, QH.,Du, XB.,...&Zhang, Y .(2016).Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease.SCIENTIFIC REPORTS,6,-.
MLA Zheng, L,et al."Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease".SCIENTIFIC REPORTS 6(2016):-.
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