中国科学院上海应用物理研究所机构知识库
Advanced  
CAS OpenIR  > 中科院上海应用物理研究所2011-2017年  > 期刊论文
题名:
Synthesis, Antiphospholipase A(2), Antiprotease, Antibacterial Evaluation and Molecular Docking Analysis of Certain Novel Hydrazones
作者: El-Sayed, NNE; Alafeefy, AM; Bakht, MA; Masand, VH; Aldalbahi, A; Chen, N; Fan, CH; Ben Bacha, A
刊名: MOLECULES
出版日期: 2016
卷号: 21, 期号:12, 页码:-
关键词: benzo[d][1,3]oxazin-4-one ; aroylhydrazides ; N-acylhydrazones ; hydrazones ; benzylidene hydrazides ; phospholipases ; proteases ; antimicrobial evaluation ; molecular docking
DOI: 10.3390/molecules21121664
通讯作者: El-Sayed, NNE (reprint author), King Saud Univ, Girls Sect, Coll Sci, Dept Chem, POB 22452, Riyadh 11495, Saudi Arabia. ; El-Sayed, NNE (reprint author), Natl Org Drug Control & Res, Giza 35521, Egypt.
文章类型: 期刊论文
英文摘要: Some novel hydrazone derivatives 6a-o were synthesized from the key intermediate 4-Chloro-N-(2-hydrazinocarbonyl-phenyl)-benzamide 5 and characterized using IR, H-1-NMR, C-13-NMR, mass spectroscopy and elemental analysis. The inhibitory potential against two secretory phospholipase A(2) (sPLA(2)), three protease enzymes and eleven bacterial strains were evaluated. The results revealed that all compounds showed preferential inhibition towards hGIIA isoform of sPLA2 rather than DrG-IB with compounds 6l and 6e being the most active. The tested compounds exhibited excellent antiprotease activity against proteinase K and protease from Bacillus sp. with compound 6l being the most active against both enzymes. Furthermore, the maximum zones of inhibition against bacterial growth were exhibited by compounds; 6a, 6m, and 6o against P. aeruginosa; 6a, 6b, 6d, 6f, 6l, 6m, 6n, and 6o against Serratia; 6k against S. mutans; and compounds 6a, 6d, 6e, 6m, and 6n against E. feacalis. The docking simulations of hydrazones 6a-o with GIIA sPLA2, proteinase K and hydrazones 6a-e with glutamine-fructose-6-phosphate transaminase were performed to obtain information regarding the mechanism of action.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000392140100058
ISSN号: 1420-3049
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/26647
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Synthesis, Antiphospholipase A(2), Antiprotease, Antibacterial Evaluation and Molecular Docking Analysis of Certain Novel Hydrazones.pdf(2164KB)期刊论文作者接受稿开放获取View Download

Recommended Citation:
El-Sayed, NNE,Alafeefy, AM,Bakht, MA,et al. Synthesis, Antiphospholipase A(2), Antiprotease, Antibacterial Evaluation and Molecular Docking Analysis of Certain Novel Hydrazones[J]. MOLECULES,2016-01-01,21(12):-.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[El-Sayed, NNE]'s Articles
[Alafeefy, AM]'s Articles
[Bakht, MA]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[El-Sayed, NNE]‘s Articles
[Alafeefy, AM]‘s Articles
[Bakht, MA]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Synthesis, Antiphospholipase A(2), Antiprotease, Antibacterial Evaluation and Molecular Docking Analysis of Certain Novel Hydrazones.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace