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题名: Terahertz identification and quantification of neurotransmitter and neurotrophy mixture
作者: Peng, Y; Yuan, XR; Zou, X; Chen, WQ; Huang, H; Zhao, HW; Song, B; Chen, L; Zhu, YM
刊名: BIOMEDICAL OPTICS EXPRESS
出版日期: 2016
卷号: 7, 期号:11, 页码:4472-4479
DOI: 10.1364/BOE.7.004472
通讯作者: Chen, L (reprint author), Fudan Univ, Hua Shan Hosp, Shanghai 200040, Peoples R China.
文章类型: 期刊论文
英文摘要: Terahertz spectroscopy has been widely used for investigating the fingerprint spectrum of different substances. For cancerous tissues, the greatest difficulty is the absorption peaks of various substances contained in tissues overlap with each other, which are hard to identify and quantitative analyze. As a result, it is very hard to measure the presence of cancer cell and then to diagnose accurately. In this paper, we select three typical neurotransmitters (gamma-aminobutyric acid, L-glutamic acid, dopamine hydrochloride) and two typical metabolites (inositol and creatine) in neurons to measure their terahertz spectra with different mixture ratios. By choosing characteristic absorption peaks, removing baseline and using the least square method, we can identify the components and proportions of each mixture, where the goodness of fit to practical situation is up to 94%. These results provide important evidences for identifying nerve substances and obtaining exact quantitative analysis. (C) 2016 Optical Society of America
收录类别: SCI
语种: 英语
WOS记录号: WOS:000387557600010
ISSN号: 2156-7085
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/26650
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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