The Development of Protein Chips for High Throughput Screening (HTS) of Chemically Labeling Small Molecular Drugs
Feng, YZ; Wang, BC; Chu, XX; Wang, YZ; Zhu, LC; Wang, BC (reprint author), Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Coll Bioengn, Shazheng St 174, Chongqing 400044, Peoples R China.
2016
发表期刊MINI-REVIEWS IN MEDICINAL CHEMISTRY
ISSN1389-5575
卷号16期号:10页码:846-850
文章类型期刊论文
摘要How to construct protein chips and chemically labeling drug molecules without disrupting structures for HTS is still a challenging area. There are two main obstacles, one is that human multitrans membrane receptors, which are major drug targets, exhibit distinct motifs, and fold structures, and they will collapse unfold without membrane support in vitro; another one is that there still lack effective chemical labeling method for small drugs for detection. Therefore, how to acquire high detecting sensitivity for small molecules and to immobilize membrane protein receptors in native conformation with uniform direction on the chip, need to be solved for drug HTS. This paper reviews drug HTS trends in recent years, proposed a new virion-chip model and a feasible C-H activation method for CY-5 labeling drugs. It is expected to provide a good platform for future drug HTS.
关键词C-h Activation Detecting Sensitivity Human Multi-trans Membrane Protein Native Conformation Small Drugs Virion-chip
DOI10.2174/1389557515666150511152922
收录类别SCI
语种英语
WOS记录号WOS:000380946500008
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/26653
专题中科院上海应用物理研究所2011-2018年
通讯作者Wang, BC (reprint author), Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Coll Bioengn, Shazheng St 174, Chongqing 400044, Peoples R China.
推荐引用方式
GB/T 7714
Feng, YZ,Wang, BC,Chu, XX,et al. The Development of Protein Chips for High Throughput Screening (HTS) of Chemically Labeling Small Molecular Drugs[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2016,16(10):846-850.
APA Feng, YZ,Wang, BC,Chu, XX,Wang, YZ,Zhu, LC,&Wang, BC .(2016).The Development of Protein Chips for High Throughput Screening (HTS) of Chemically Labeling Small Molecular Drugs.MINI-REVIEWS IN MEDICINAL CHEMISTRY,16(10),846-850.
MLA Feng, YZ,et al."The Development of Protein Chips for High Throughput Screening (HTS) of Chemically Labeling Small Molecular Drugs".MINI-REVIEWS IN MEDICINAL CHEMISTRY 16.10(2016):846-850.
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