CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
The Development of Protein Chips for High Throughput Screening (HTS) of Chemically Labeling Small Molecular Drugs
Feng, YZ; Wang, BC; Chu, XX; Wang, YZ; Zhu, LC; Wang, BC (reprint author), Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Coll Bioengn, Shazheng St 174, Chongqing 400044, Peoples R China.
2016
Source PublicationMINI-REVIEWS IN MEDICINAL CHEMISTRY
ISSN1389-5575
Volume16Issue:10Pages:846-850
Subtype期刊论文
AbstractHow to construct protein chips and chemically labeling drug molecules without disrupting structures for HTS is still a challenging area. There are two main obstacles, one is that human multitrans membrane receptors, which are major drug targets, exhibit distinct motifs, and fold structures, and they will collapse unfold without membrane support in vitro; another one is that there still lack effective chemical labeling method for small drugs for detection. Therefore, how to acquire high detecting sensitivity for small molecules and to immobilize membrane protein receptors in native conformation with uniform direction on the chip, need to be solved for drug HTS. This paper reviews drug HTS trends in recent years, proposed a new virion-chip model and a feasible C-H activation method for CY-5 labeling drugs. It is expected to provide a good platform for future drug HTS.
KeywordC-h Activation Detecting Sensitivity Human Multi-trans Membrane Protein Native Conformation Small Drugs Virion-chip
DOI10.2174/1389557515666150511152922
Indexed BySCI
Language英语
WOS IDWOS:000380946500008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/26653
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorWang, BC (reprint author), Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Coll Bioengn, Shazheng St 174, Chongqing 400044, Peoples R China.
Recommended Citation
GB/T 7714
Feng, YZ,Wang, BC,Chu, XX,et al. The Development of Protein Chips for High Throughput Screening (HTS) of Chemically Labeling Small Molecular Drugs[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2016,16(10):846-850.
APA Feng, YZ,Wang, BC,Chu, XX,Wang, YZ,Zhu, LC,&Wang, BC .(2016).The Development of Protein Chips for High Throughput Screening (HTS) of Chemically Labeling Small Molecular Drugs.MINI-REVIEWS IN MEDICINAL CHEMISTRY,16(10),846-850.
MLA Feng, YZ,et al."The Development of Protein Chips for High Throughput Screening (HTS) of Chemically Labeling Small Molecular Drugs".MINI-REVIEWS IN MEDICINAL CHEMISTRY 16.10(2016):846-850.
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