The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution

doi:10.1111/cbdd.12740

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution
	Liu, YX; Cheng, DF; Ge, M; Lin, WZ; Lin, WZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Ctr Thorium Molten Salt Reactor Syst, 2019 Jialuo Rd, Shanghai 201800, Peoples R China.; Cheng, DF (reprint author), Fudan Univ, Dept Nucl Med, Zhongshan Hosp, 180 Fenglin Rd, Shanghai 200032, Peoples R China.; Cheng, DF (reprint author), Shanghai Inst Med Imaging, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
	2016
发表期刊	CHEMICAL BIOLOGY & DRUG DESIGN
ISSN	1747-0277
卷号	88 期号:1 页码:122-128
文章类型	期刊论文
摘要	In 80-90% tumor cells, telomerase becomes active and stabilizes the length of telomeres. The formation and stabilization of G-quadruplexes formed from human telomeric sequences have been proved able to inhibit the activity of telomerase, thus human telomeric G-quadruplex structure has become a potential target for the development of cancer therapy. Hence, structure of G-quadruplex formed in K+ solution has been an attractive hotspot for further studies. However, the exact structure of human telomeric G-quadruplex in K+ is extremely controversial, this study provides information for the understanding of different G-quadruplexes. Here, we report that 22nt and 24nt human telomeric sequences form unimolecular hybrid-type mixed parallel/antiparallel G-quadruplex in K+ solution elucidated utilizing Circular Dichroism, Differential Scanning Calorimetry, and gel electrophoresis. Moreover, individual configuration of these two sequences was speculated in this study. The detailed structure information of the G-quadruplex formed under physiologically relevant condition is necessary for structure-based rational drug design.
关键词	Anticancer Drug Circular Dichroism Differential Scanning Calorimetry G-quadruplex Telomerase Telomeric Dna
DOI	10.1111/cbdd.12740
收录类别	SCI
语种	英语
WOS记录号	WOS:000378698600012
引用统计
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/26660
专题	中科院上海应用物理研究所2011-2018年
通讯作者	Lin, WZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Ctr Thorium Molten Salt Reactor Syst, 2019 Jialuo Rd, Shanghai 201800, Peoples R China.; Cheng, DF (reprint author), Fudan Univ, Dept Nucl Med, Zhongshan Hosp, 180 Fenglin Rd, Shanghai 200032, Peoples R China.; Cheng, DF (reprint author), Shanghai Inst Med Imaging, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
推荐引用方式 GB/T 7714	Liu, YX,Cheng, DF,Ge, M,et al. The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution[J]. CHEMICAL BIOLOGY & DRUG DESIGN,2016,88(1):122-128.
APA	Liu, YX.,Cheng, DF.,Ge, M.,Lin, WZ.,Lin, WZ .,...&Cheng, DF .(2016).The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution.CHEMICAL BIOLOGY & DRUG DESIGN,88(1),122-128.
MLA	Liu, YX,et al."The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution".CHEMICAL BIOLOGY & DRUG DESIGN 88.1(2016):122-128.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
The Truncated Human （697KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	请求全文