The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution
Liu, YX; Cheng, DF; Ge, M; Lin, WZ; Lin, WZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Ctr Thorium Molten Salt Reactor Syst, 2019 Jialuo Rd, Shanghai 201800, Peoples R China.; Cheng, DF (reprint author), Fudan Univ, Dept Nucl Med, Zhongshan Hosp, 180 Fenglin Rd, Shanghai 200032, Peoples R China.; Cheng, DF (reprint author), Shanghai Inst Med Imaging, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
2016
发表期刊CHEMICAL BIOLOGY & DRUG DESIGN
ISSN1747-0277
卷号88期号:1页码:122-128
文章类型期刊论文
摘要In 80-90% tumor cells, telomerase becomes active and stabilizes the length of telomeres. The formation and stabilization of G-quadruplexes formed from human telomeric sequences have been proved able to inhibit the activity of telomerase, thus human telomeric G-quadruplex structure has become a potential target for the development of cancer therapy. Hence, structure of G-quadruplex formed in K+ solution has been an attractive hotspot for further studies. However, the exact structure of human telomeric G-quadruplex in K+ is extremely controversial, this study provides information for the understanding of different G-quadruplexes. Here, we report that 22nt and 24nt human telomeric sequences form unimolecular hybrid-type mixed parallel/antiparallel G-quadruplex in K+ solution elucidated utilizing Circular Dichroism, Differential Scanning Calorimetry, and gel electrophoresis. Moreover, individual configuration of these two sequences was speculated in this study. The detailed structure information of the G-quadruplex formed under physiologically relevant condition is necessary for structure-based rational drug design.
关键词Anticancer Drug Circular Dichroism Differential Scanning Calorimetry G-quadruplex Telomerase Telomeric Dna
DOI10.1111/cbdd.12740
收录类别SCI
语种英语
WOS记录号WOS:000378698600012
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/26660
专题中科院上海应用物理研究所2011-2018年
通讯作者Lin, WZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Ctr Thorium Molten Salt Reactor Syst, 2019 Jialuo Rd, Shanghai 201800, Peoples R China.; Cheng, DF (reprint author), Fudan Univ, Dept Nucl Med, Zhongshan Hosp, 180 Fenglin Rd, Shanghai 200032, Peoples R China.; Cheng, DF (reprint author), Shanghai Inst Med Imaging, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
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Liu, YX,Cheng, DF,Ge, M,et al. The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution[J]. CHEMICAL BIOLOGY & DRUG DESIGN,2016,88(1):122-128.
APA Liu, YX.,Cheng, DF.,Ge, M.,Lin, WZ.,Lin, WZ .,...&Cheng, DF .(2016).The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution.CHEMICAL BIOLOGY & DRUG DESIGN,88(1),122-128.
MLA Liu, YX,et al."The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution".CHEMICAL BIOLOGY & DRUG DESIGN 88.1(2016):122-128.
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