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The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution
Liu, YX; Cheng, DF; Ge, M; Lin, WZ; Lin, WZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Ctr Thorium Molten Salt Reactor Syst, 2019 Jialuo Rd, Shanghai 201800, Peoples R China.; Cheng, DF (reprint author), Fudan Univ, Dept Nucl Med, Zhongshan Hosp, 180 Fenglin Rd, Shanghai 200032, Peoples R China.; Cheng, DF (reprint author), Shanghai Inst Med Imaging, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
2016
Source PublicationCHEMICAL BIOLOGY & DRUG DESIGN
ISSN1747-0277
Volume88Issue:1Pages:122-128
Subtype期刊论文
AbstractIn 80-90% tumor cells, telomerase becomes active and stabilizes the length of telomeres. The formation and stabilization of G-quadruplexes formed from human telomeric sequences have been proved able to inhibit the activity of telomerase, thus human telomeric G-quadruplex structure has become a potential target for the development of cancer therapy. Hence, structure of G-quadruplex formed in K+ solution has been an attractive hotspot for further studies. However, the exact structure of human telomeric G-quadruplex in K+ is extremely controversial, this study provides information for the understanding of different G-quadruplexes. Here, we report that 22nt and 24nt human telomeric sequences form unimolecular hybrid-type mixed parallel/antiparallel G-quadruplex in K+ solution elucidated utilizing Circular Dichroism, Differential Scanning Calorimetry, and gel electrophoresis. Moreover, individual configuration of these two sequences was speculated in this study. The detailed structure information of the G-quadruplex formed under physiologically relevant condition is necessary for structure-based rational drug design.
KeywordAnticancer Drug Circular Dichroism Differential Scanning Calorimetry G-quadruplex Telomerase Telomeric Dna
DOI10.1111/cbdd.12740
Indexed BySCI
Language英语
WOS IDWOS:000378698600012
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/26660
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorLin, WZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Ctr Thorium Molten Salt Reactor Syst, 2019 Jialuo Rd, Shanghai 201800, Peoples R China.; Cheng, DF (reprint author), Fudan Univ, Dept Nucl Med, Zhongshan Hosp, 180 Fenglin Rd, Shanghai 200032, Peoples R China.; Cheng, DF (reprint author), Shanghai Inst Med Imaging, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
Recommended Citation
GB/T 7714
Liu, YX,Cheng, DF,Ge, M,et al. The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution[J]. CHEMICAL BIOLOGY & DRUG DESIGN,2016,88(1):122-128.
APA Liu, YX.,Cheng, DF.,Ge, M.,Lin, WZ.,Lin, WZ .,...&Cheng, DF .(2016).The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution.CHEMICAL BIOLOGY & DRUG DESIGN,88(1),122-128.
MLA Liu, YX,et al."The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution".CHEMICAL BIOLOGY & DRUG DESIGN 88.1(2016):122-128.
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