中国科学院上海应用物理研究所机构知识库
Advanced  
CAS OpenIR  > 中科院上海应用物理研究所2011-2017年  > 期刊论文
题名:
The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution
作者: Liu, YX; Cheng, DF; Ge, M; Lin, WZ
刊名: CHEMICAL BIOLOGY & DRUG DESIGN
出版日期: 2016
卷号: 88, 期号:1, 页码:122-128
关键词: anticancer drug ; Circular Dichroism ; differential scanning calorimetry ; G-quadruplex ; telomerase ; telomeric DNA
DOI: 10.1111/cbdd.12740
通讯作者: Lin, WZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Ctr Thorium Molten Salt Reactor Syst, 2019 Jialuo Rd, Shanghai 201800, Peoples R China. ; Cheng, DF (reprint author), Fudan Univ, Dept Nucl Med, Zhongshan Hosp, 180 Fenglin Rd, Shanghai 200032, Peoples R China. ; Cheng, DF (reprint author), Shanghai Inst Med Imaging, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
文章类型: 期刊论文
英文摘要: In 80-90% tumor cells, telomerase becomes active and stabilizes the length of telomeres. The formation and stabilization of G-quadruplexes formed from human telomeric sequences have been proved able to inhibit the activity of telomerase, thus human telomeric G-quadruplex structure has become a potential target for the development of cancer therapy. Hence, structure of G-quadruplex formed in K+ solution has been an attractive hotspot for further studies. However, the exact structure of human telomeric G-quadruplex in K+ is extremely controversial, this study provides information for the understanding of different G-quadruplexes. Here, we report that 22nt and 24nt human telomeric sequences form unimolecular hybrid-type mixed parallel/antiparallel G-quadruplex in K+ solution elucidated utilizing Circular Dichroism, Differential Scanning Calorimetry, and gel electrophoresis. Moreover, individual configuration of these two sequences was speculated in this study. The detailed structure information of the G-quadruplex formed under physiologically relevant condition is necessary for structure-based rational drug design.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000378698600012
ISSN号: 1747-0277
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/26660
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel_antiparallel G-quadruplex Structure in K+ Solution.pdf(697KB)期刊论文作者接受稿开放获取View Download

Recommended Citation:
Liu, YX,Cheng, DF,Ge, M,et al. The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K+ Solution[J]. CHEMICAL BIOLOGY & DRUG DESIGN,2016-01-01,88(1):122-128.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, YX]'s Articles
[Cheng, DF]'s Articles
[Ge, M]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, YX]‘s Articles
[Cheng, DF]‘s Articles
[Ge, M]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel_antiparallel G-quadruplex Structure in K+ Solution.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace