Three dimensional plasmonic assemblies of AuNPs with an overall size of sub-200 nm for chemo-photothermal synergistic therapy of breast cancer
Xia, YZ; Wu, XX; Zhao, JT; Zhao, JS; Li, ZH; Ren, WZ; Tian, YC; Li, AG; Shen, ZY; Wu, AG; Wu, AG (reprint author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Magnet Mat & Devices, 1219 Zhong Guan West Rd, Ningbo 315201, Zhejiang, Peoples R China.; Wu, AG (reprint author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Addit Mfg Mat Zhejiang Prov, 1219 Zhong Guan West Rd, Ningbo 315201, Zhejiang, Peoples R China.; Wu, AG (reprint author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Div Funct Mat & Nanodevices, 1219 Zhong Guan West Rd, Ningbo 315201, Zhejiang, Peoples R China.
2016
发表期刊NANOSCALE
ISSN2040-3364
卷号8期号:44页码:18682-18692
文章类型期刊论文
摘要Three dimensional plasmonic assemblies of gold nanoparticles (AuNPs) (gold 3D-PAs) have been recently developed for photothermal therapy, Raman imaging, photoacoustic imaging or X-ray computed tomography imaging because they can generate an enhanced electromagnetic field between the gaps of neighboring AuNPs and significantly improve the localized surface plasmon resonance (LSPR) effect in the near-infrared (NIR) region. However, the sizes of most reported gold 3D-PAs are too large (>300 nm) for in vivo applications as cancer theranostic agents because a size of about 200 nm is often considered to be the upper limit for successful drug delivery based on the enhanced permeation and retention (EPR) effect. Herein, we propose a novel strategy to fabricate the gold 3D-PAs with an overall size of sub-200 nm, whose self-assembly process was verified by TEM, DLS and UV-vis spectroscopy. The cell experiments demonstrate that our gold 3D-PAs allow combined chemotherapy and photothermal therapy. The histopathology assessments indicate that the toxicity of our gold 3D-PAs to normal tissues (side effect) is negligible. The animal experiments indicate that our gold 3D-PAs have a weak chemotherapeutic efficacy without NIR laser irradiation at a low DOX dosage, but shows an excellent therapeutic effect with NIR laser irradiation at the same DOX dosage due to the synergy of chemo-photothermal therapy.
DOI10.1039/c6nr07172d
收录类别SCI
语种英语
WOS记录号WOS:000387858700014
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/26663
专题中科院上海应用物理研究所2011-2018年
通讯作者Shen, ZY; Wu, AG (reprint author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Magnet Mat & Devices, 1219 Zhong Guan West Rd, Ningbo 315201, Zhejiang, Peoples R China.; Wu, AG (reprint author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Addit Mfg Mat Zhejiang Prov, 1219 Zhong Guan West Rd, Ningbo 315201, Zhejiang, Peoples R China.; Wu, AG (reprint author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Div Funct Mat & Nanodevices, 1219 Zhong Guan West Rd, Ningbo 315201, Zhejiang, Peoples R China.
推荐引用方式
GB/T 7714
Xia, YZ,Wu, XX,Zhao, JT,et al. Three dimensional plasmonic assemblies of AuNPs with an overall size of sub-200 nm for chemo-photothermal synergistic therapy of breast cancer[J]. NANOSCALE,2016,8(44):18682-18692.
APA Xia, YZ.,Wu, XX.,Zhao, JT.,Zhao, JS.,Li, ZH.,...&Wu, AG .(2016).Three dimensional plasmonic assemblies of AuNPs with an overall size of sub-200 nm for chemo-photothermal synergistic therapy of breast cancer.NANOSCALE,8(44),18682-18692.
MLA Xia, YZ,et al."Three dimensional plasmonic assemblies of AuNPs with an overall size of sub-200 nm for chemo-photothermal synergistic therapy of breast cancer".NANOSCALE 8.44(2016):18682-18692.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Three dimensional pl(5551KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xia, YZ]的文章
[Wu, XX]的文章
[Zhao, JT]的文章
百度学术
百度学术中相似的文章
[Xia, YZ]的文章
[Wu, XX]的文章
[Zhao, JT]的文章
必应学术
必应学术中相似的文章
[Xia, YZ]的文章
[Wu, XX]的文章
[Zhao, JT]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Three dimensional plasmonic assemblies of AuNPs with an overall size of sub-200 nm for chemo-photothermal synergistic therapy of breast cancer.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。