CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Three dimensional structural insight of laser drilled orifices in osmotic pump tablets
Wu, L; Wang, LB; Wang, SX; Xiao, TQ; Chen, M; Shao, Q; York, P; Singh, V; Yin, XZ; Gu, JK; Zhang, JW; Gu, JK (reprint author), Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China.; Zhang, JW (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China.
2016
Source PublicationEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
ISSN0928-0987
Volume93Pages:287-294
Subtype期刊论文
AbstractThe orifice drilled in the membrane as a channel for drug delivery is the key functional part of the osmotic pumps for a controlled drug release system. Reported conventional microscopic evaluations of these orifices have been limited to measurement of two-dimensional cross-section diameters. This study was aimed at establishing a novel method to measure quantitatively the three-dimensional architectures of orifices based on synchrotron radiation X-ray microcomputed tomography (SR-mu CT). Quantitative analysis of architectures extracted from captopril osmotic pumps drilled by a range of operating parameters indicated that laser power correlated with the cross section area, volume, surface area and depth of the orifices, while scanning speed of laser beam showed inverse relationships with the above structure characters. The synchrotron radiation based Fourier transform infrared microspectroscopy mapping showed that there was no apparent chemical change in the surrounding area of the orifice compared with the normal membrane region. Thus SR-mu CT was successfully applied to marketed felodipine osmotic pumps for architectural evaluation of the orifices. In conclusion, the first three-dimensional structural insight of orifices in osmotic pump tablets by SR-mu CT and structural reconstruction for the architectures has provided deeper insight into improving the design of advanced osmotic pumps for controlled drug release. (C) 2016 Published by Elsevier B.V.
KeywordStructure Osmotic Pump Tablet Synchrotron Radiation X-ray Microcomputed Tomography Laser Drilling
DOI10.1016/j.ejps.2016.08.039
Indexed BySCI
Language英语
WOS IDWOS:000384853200031
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/26664
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorYin, XZ; Gu, JK (reprint author), Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China.; Zhang, JW (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China.
Recommended Citation
GB/T 7714
Wu, L,Wang, LB,Wang, SX,et al. Three dimensional structural insight of laser drilled orifices in osmotic pump tablets[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2016,93:287-294.
APA Wu, L.,Wang, LB.,Wang, SX.,Xiao, TQ.,Chen, M.,...&Zhang, JW .(2016).Three dimensional structural insight of laser drilled orifices in osmotic pump tablets.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,93,287-294.
MLA Wu, L,et al."Three dimensional structural insight of laser drilled orifices in osmotic pump tablets".EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 93(2016):287-294.
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