Three dimensional structural insight of laser drilled orifices in osmotic pump tablets
Wu, L; Wang, LB; Wang, SX; Xiao, TQ; Chen, M; Shao, Q; York, P; Singh, V; Yin, XZ; Gu, JK; Zhang, JW; Gu, JK (reprint author), Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China.; Zhang, JW (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China.
2016
发表期刊EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
ISSN0928-0987
卷号93页码:287-294
文章类型期刊论文
摘要The orifice drilled in the membrane as a channel for drug delivery is the key functional part of the osmotic pumps for a controlled drug release system. Reported conventional microscopic evaluations of these orifices have been limited to measurement of two-dimensional cross-section diameters. This study was aimed at establishing a novel method to measure quantitatively the three-dimensional architectures of orifices based on synchrotron radiation X-ray microcomputed tomography (SR-mu CT). Quantitative analysis of architectures extracted from captopril osmotic pumps drilled by a range of operating parameters indicated that laser power correlated with the cross section area, volume, surface area and depth of the orifices, while scanning speed of laser beam showed inverse relationships with the above structure characters. The synchrotron radiation based Fourier transform infrared microspectroscopy mapping showed that there was no apparent chemical change in the surrounding area of the orifice compared with the normal membrane region. Thus SR-mu CT was successfully applied to marketed felodipine osmotic pumps for architectural evaluation of the orifices. In conclusion, the first three-dimensional structural insight of orifices in osmotic pump tablets by SR-mu CT and structural reconstruction for the architectures has provided deeper insight into improving the design of advanced osmotic pumps for controlled drug release. (C) 2016 Published by Elsevier B.V.
关键词Structure Osmotic Pump Tablet Synchrotron Radiation X-ray Microcomputed Tomography Laser Drilling
DOI10.1016/j.ejps.2016.08.039
收录类别SCI
语种英语
WOS记录号WOS:000384853200031
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/26664
专题中科院上海应用物理研究所2011-2018年
通讯作者Yin, XZ; Gu, JK (reprint author), Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China.; Zhang, JW (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China.
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Wu, L,Wang, LB,Wang, SX,et al. Three dimensional structural insight of laser drilled orifices in osmotic pump tablets[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2016,93:287-294.
APA Wu, L.,Wang, LB.,Wang, SX.,Xiao, TQ.,Chen, M.,...&Zhang, JW .(2016).Three dimensional structural insight of laser drilled orifices in osmotic pump tablets.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,93,287-294.
MLA Wu, L,et al."Three dimensional structural insight of laser drilled orifices in osmotic pump tablets".EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 93(2016):287-294.
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