Visualization and Pathological Characteristics of Hepatic Alveolar Echinococcosis with Synchrotron-based X-ray Phase Sensitive Micro-tomography
Liu, HQ; Ji, XW; Sun, L; Xiao, TQ; Xie, HL; Fu, YN; Zhao, Y; Liu, WY; Zhang, XL; Lin, RY; Liu, HQ (reprint author), Xinjiang Med Univ, Coll Med Engn & Technol, Urumqi 830011, Peoples R China.
2016
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号6页码:-
文章类型期刊论文
摘要Propagation-based phase-contrast computed tomography (PPCT) utilizes highly sensitive phase-contrast technology applied to X-ray micro-tomography, especially with the extensive use of synchrotron radiation (SR). Performing phase retrieval (PR) on the acquired angular projections can enhance image contrast and enable quantitative imaging. We employed the combination of SR-PPCT and PR for the histopathological evaluation of hepatic alveolar echinococcosis (HAE) disease and demonstrated the validity and superiority of PR-based SR-PPCT. A high-resolution angular projection data set of a human postoperative specimen of HAE disease was acquired, which was processed by graded ethanol concentration fixation (GECF). The reconstructed images from both approaches, with the projection data directly used and preprocessed by PR for tomographic reconstruction, were compared in terms of the tissue contrast-to-noise ratio and density spatial resolution. The PR-based SR-PPCT was selected for microscale measurement and the 3D visualization of HAE disease. Our experimental results demonstrated that the PR-based SR-PPCT technique is greatly suitable for the discrimination of pathological tissues and the characterization of HAE. In addition, this new technique is superior to conventional hospital CT and microscopy for the three-dimensional, non-destructive microscale measurement of HAE. This PR-based SR-PPCT technique has great potential for in situmicroscale histopathological analysis and diagnosis, especially for applications involving soft tissues and organs.
DOI10.1038/srep38085
收录类别SCI
语种英语
WOS记录号WOS:000388666300001
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/26677
专题中科院上海应用物理研究所2011-2018年
通讯作者Liu, HQ (reprint author), Xinjiang Med Univ, Coll Med Engn & Technol, Urumqi 830011, Peoples R China.
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GB/T 7714
Liu, HQ,Ji, XW,Sun, L,et al. Visualization and Pathological Characteristics of Hepatic Alveolar Echinococcosis with Synchrotron-based X-ray Phase Sensitive Micro-tomography[J]. SCIENTIFIC REPORTS,2016,6:-.
APA Liu, HQ.,Ji, XW.,Sun, L.,Xiao, TQ.,Xie, HL.,...&Liu, HQ .(2016).Visualization and Pathological Characteristics of Hepatic Alveolar Echinococcosis with Synchrotron-based X-ray Phase Sensitive Micro-tomography.SCIENTIFIC REPORTS,6,-.
MLA Liu, HQ,et al."Visualization and Pathological Characteristics of Hepatic Alveolar Echinococcosis with Synchrotron-based X-ray Phase Sensitive Micro-tomography".SCIENTIFIC REPORTS 6(2016):-.
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