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A Light-Responsive Self-Assembly Formed by a Cationic Azobenzene Derivative and SDS as a Drug Delivery System
Geng, SY; Wang, YZ; Wang, LP; Kouyama, T; Gotoh, T; Wada, S; Wang, JY
2017
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume7Pages:-
Subtype期刊论文
AbstractThe structure of a self-assembly formed from a cationic azobenzene derivative, 4-cholesterocarbonyl-4'-(N, N, N-triethylamine butyloxyl bromide) azobenzene (CAB) and surfactant sodium dodecyl sulfate (SDS) in aqueous solution was studied by cryo-TEM and synchrotron radiation small-angle X-ray scattering (SAXS). Both unilamellar and multilamellar vesicles could be observed. CAB in vesicles were capable to undergo reversible trans-to-cis isomerization upon UV or visible light irradiation. The structural change upon UV light irradiation could be catched by SAXS, which demonstrated that the interlamellar spacing of the cis-multilamellar vesicles increased by 0.2-0.3 nm. Based on this microstructural change, the release of rhodamine B (RhB) and doxorubicin (DOX) could be triggered by UV irradiation. When incubated NIH 3T3 cells and Bel 7402 cells with DOX-loaded CAB/SDS vesicles, UV irradiation induced DOX release decreased the viability of both cell lines significantly compared with the non-irradiated cells. The in vitro experiment indicated that CAB/SDS vesicles had high efficiency to deliver loaded molecules into cells. The in vivo experiment showed that CAB/SDS vesicles not only have high drug delivery efficiency into rat retinas, but also could maintain high drug concentration for a longer time. CAB/SDS catanionic vesicles may find potential applications as a smart drug delivery system for controlled release by light.
DOI10.1038/srep39202
Indexed BySCI
Language英语
WOS IDWOS:000391096400001
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/27243
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Geng, SY,Wang, YZ,Wang, LP,et al. A Light-Responsive Self-Assembly Formed by a Cationic Azobenzene Derivative and SDS as a Drug Delivery System[J]. SCIENTIFIC REPORTS,2017,7:-.
APA Geng, SY.,Wang, YZ.,Wang, LP.,Kouyama, T.,Gotoh, T.,...&Wang, JY.(2017).A Light-Responsive Self-Assembly Formed by a Cationic Azobenzene Derivative and SDS as a Drug Delivery System.SCIENTIFIC REPORTS,7,-.
MLA Geng, SY,et al."A Light-Responsive Self-Assembly Formed by a Cationic Azobenzene Derivative and SDS as a Drug Delivery System".SCIENTIFIC REPORTS 7(2017):-.
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