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题名:
Autophagy and lysosomal dysfunction: A new insight into mechanism of synergistic pulmonary toxicity of carbon black-metal ions co-exposure
作者: Kong, HT; Xia, K; Pan, L; Zhang, JC; Luo, Y; Zhang, Y; Cui, ZF; El-Sayed, NN; Aldalbahi, A; Chen, N; Li, AG; Tai, RZ; Fan, CH; Zhu, Y
刊名: CARBON
出版日期: 2017
卷号: 111, 页码:322-333
DOI: 10.1016/j.carbon.2016.10.015
文章类型: 期刊论文
英文摘要: Fine particulate matter (PM 2.5) is the principal instigators of adverse health events, yet gaps still remain in understanding the mechanism mediating its toxic response. Similar to nanoparticles, PM 2.5, with large surface area to volume ratio, can absorb multipollutants in air, displaying toxicity profiles that are very different from those of coarse particles of the same composition. One particularly relevant interaction is that of PM 2.5 and the anthropogenic metals. In this study, we used carbon black nanoparticle (CBs) and metal ions as model materials to investigate the synergistic pulmonary toxicity and its mechanism. We demonstrated that excessive metal contaminants adsorbed on CBs contributed to the observed toxic effects both in vitro and in C57BL6 mice intratracheal instillation model. Significantly, we found that autophagy and lysosomal dysfunction accounted for the synergistic pulmonary toxic effect of co-exposure to CBs and metals. Our findings provide a new insight into understanding the toxicological and healthy effects of fine particles, which have potential to aid in mitigating their adverse health effect. (C) 2016 Elsevier Ltd. All rights reserved.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000389555500037
ISSN号: 0008-6223
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/27263
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Kong, HT,Xia, K,Pan, L,et al. Autophagy and lysosomal dysfunction: A new insight into mechanism of synergistic pulmonary toxicity of carbon black-metal ions co-exposure[J]. CARBON,2017-01-01,111:322-333.
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文件名: Autophagy and lysosomal dysfunction_ A new insight into mechanism of synergistic pulmonary toxicity of carbon black-metal ions co-exposure.pdf
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