Clamped Hybridization Chain Reactions for the Self-Assembly of Patterned DNA Hydrogels
Wang, JB; Chao, J; Liu, HJ; Su, S; Wang, LH; Huang, W; Willner, I; Fan, CH
2017
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
卷号56期号:8页码:2171-2175
文章类型期刊论文
摘要DNA hydrogels hold great potential for biological and biomedical applications owing to their programmable nature and macroscopic sizes. However, most previous studies involve spontaneous and homogenous gelation procedures in solution, which often lack precise control. A clamped hybridization chain reaction (C-HCR)-based strategy has been developed to guide DNA self-assembly to form macroscopic hydrogels. Analogous to catalysts in chemical synthesis or seeds in crystal growth, we introduced DNA initiators to induce the gelation process, including crosslinked self-assembly and clamped hybridization in three dimensions with spatial and temporal control. The formed hydrogels show superior mechanical properties. The use of printed, surface-confined DNA initiators was also demonstrated for fabricating 2D hydrogel patterns without relying on external confinements. This simple method can be used to construct DNA hydrogels with defined geometry, composition, and order for various bioapplications.
关键词Dna Hydrogels Dna Nanotechnology Nucleic Acid Hybridization Self-assembly Sol-gel Process
DOI10.1002/anie.201610125
收录类别SCI
语种英语
WOS记录号WOS:000397323300038
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/27274
专题中科院上海应用物理研究所2011-2018年
推荐引用方式
GB/T 7714
Wang, JB,Chao, J,Liu, HJ,et al. Clamped Hybridization Chain Reactions for the Self-Assembly of Patterned DNA Hydrogels[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2017,56(8):2171-2175.
APA Wang, JB.,Chao, J.,Liu, HJ.,Su, S.,Wang, LH.,...&Fan, CH.(2017).Clamped Hybridization Chain Reactions for the Self-Assembly of Patterned DNA Hydrogels.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,56(8),2171-2175.
MLA Wang, JB,et al."Clamped Hybridization Chain Reactions for the Self-Assembly of Patterned DNA Hydrogels".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56.8(2017):2171-2175.
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