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CAS OpenIR  > 中科院上海应用物理研究所2011-2017年  > 期刊论文
题名:
Clamped Hybridization Chain Reactions for the Self-Assembly of Patterned DNA Hydrogels
作者: Wang, JB; Chao, J; Liu, HJ; Su, S; Wang, LH; Huang, W; Willner, I; Fan, CH
刊名: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
出版日期: 2017
卷号: 56, 期号:8, 页码:2171-2175
关键词: DNA hydrogels ; DNA nanotechnology ; nucleic acid hybridization ; self-assembly ; sol-gel process
DOI: 10.1002/anie.201610125
文章类型: 期刊论文
英文摘要: DNA hydrogels hold great potential for biological and biomedical applications owing to their programmable nature and macroscopic sizes. However, most previous studies involve spontaneous and homogenous gelation procedures in solution, which often lack precise control. A clamped hybridization chain reaction (C-HCR)-based strategy has been developed to guide DNA self-assembly to form macroscopic hydrogels. Analogous to catalysts in chemical synthesis or seeds in crystal growth, we introduced DNA initiators to induce the gelation process, including crosslinked self-assembly and clamped hybridization in three dimensions with spatial and temporal control. The formed hydrogels show superior mechanical properties. The use of printed, surface-confined DNA initiators was also demonstrated for fabricating 2D hydrogel patterns without relying on external confinements. This simple method can be used to construct DNA hydrogels with defined geometry, composition, and order for various bioapplications.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000397323300038
ISSN号: 1433-7851
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/27274
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Wang, JB,Chao, J,Liu, HJ,et al. Clamped Hybridization Chain Reactions for the Self-Assembly of Patterned DNA Hydrogels[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2017-01-01,56(8):2171-2175.
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文件名: Clamped Hybridization Chain Reactions for the Self-Assembly of Patterned DNA Hydrogels.pdf
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