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Concurrent methylation and demethylation of arsenic by fungi and their differential expression in the protoplasm proteome
Su, SM; Zeng, XB; Bai, LY; Wang, YA; Zhang, LL; Li, MS; Wu, CX
2017
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
Volume225Pages:620-627
Subtype期刊论文
AbstractMicrobial methylation and demethylation are central to arsenic's (As) biogeochemical cycling. Here, the transformations of monomethylarsonic acid (MMA(V)) (50 mg L-1) for 15 days in cells of As-methylating fungi, Fusarium oxysporum CZ-8F1, Penicillium janthinellum SM-12F4, and Trichoderma asperellum SM-12F1, were evaluated, and trace concentrations of As(III) and As(V) were observed in fungal cell extracts. Trace amounts of DMA(V) were also detected in MMA(V) and P.janthinellum SM-12F4 incubations. In situ X-ray absorption near edge structure (XANES) indicated that after exposure to MMA(V) (500 mg L-1) for 15 days, 28.6-48.6% of accumulated As in fungal cells was DMA(V), followed by 18.4 -30.3% from As(V), 0-28.1% from As(III), and 4.8-28.9% from MMA(V). The concurrent methylation and demethylation of As occurs in fungal cells. Furthermore, a majority of proteins involved in metabolism, transport, ATP activity, biosynthesis, signal transduction, DNA activity, translation, and oxidative stress were upregulated in T. asperellum SM-12F1 cells after MMA(V) exposure compared to As(III), As(V), and DMA(V). The detoxification process of T. asperellum SM-12F1 was As species-specific. Methylenetetrahydrofolate reductase (R7YMHO) donation of a methyl group for S-adenosylmethionine (SAM) generation significantly increased following MMA(V) exposure. (C) 2017 Elsevier Ltd. All rights reserved.
KeywordDemethylation Mma(v) Xanes Fungi Itraq
DOI10.1016/j.envpol.2017.03.030
Indexed BySCI
Language英语
WOS IDWOS:000401679200067
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/27282
Collection中科院上海应用物理研究所2011-2018年
Recommended Citation
GB/T 7714
Su, SM,Zeng, XB,Bai, LY,et al. Concurrent methylation and demethylation of arsenic by fungi and their differential expression in the protoplasm proteome[J]. ENVIRONMENTAL POLLUTION,2017,225:620-627.
APA Su, SM.,Zeng, XB.,Bai, LY.,Wang, YA.,Zhang, LL.,...&Wu, CX.(2017).Concurrent methylation and demethylation of arsenic by fungi and their differential expression in the protoplasm proteome.ENVIRONMENTAL POLLUTION,225,620-627.
MLA Su, SM,et al."Concurrent methylation and demethylation of arsenic by fungi and their differential expression in the protoplasm proteome".ENVIRONMENTAL POLLUTION 225(2017):620-627.
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