CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material
Wang, ZW; Ma, YH; Wei, J; Chen, X; Cao, LH; Weng, WZ; Li, Q; Guo, H; Su, JC
2017
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume7Pages:-
Subtype期刊论文
AbstractMagnesium phosphate (MP) was fabricated using a chemical precipitation method, and the biological performances of MP sintered at different temperatures as a biomedical material was investigated. The results indicated that the densification and crystallinity of MP increased as the sintering temperature increased. As the sintering temperature increased, the degradability of MP in PBS decreased, and the mineralization ability in SBF significantly increased. In addition, the MP sintered at 800 degrees C (MP8) possessed the lowest degradability and highest mineralization ability. Moreover, the positive response of MG63 cells to MP significantly increased as the sintering temperature increased, and MP8 significantly promoted the cell spreading, proliferation, differentiation and expressions of osteogenic differentiation-related genes. Faster degradation of MP0 resulted in higher pH environments and ion concentrations, which led to negative responses to osteoblasts. However, the appropriate degradation of MP8 resulted in suitable pH environments and ion concentrations, which led to positive responses to osteoblasts. This study demonstrated that the sintering temperature substantially affected the surface morphology/microstructure, degradability and mineralization, and osteoblasts response to magnesium phosphate.
DOI10.1038/s41598-017-00905-2
Indexed BySCI
Language英语
WOS IDWOS:000398824300040
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/27306
Collection中科院上海应用物理研究所2011-2018年
Recommended Citation
GB/T 7714
Wang, ZW,Ma, YH,Wei, J,et al. Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material[J]. SCIENTIFIC REPORTS,2017,7:-.
APA Wang, ZW.,Ma, YH.,Wei, J.,Chen, X.,Cao, LH.,...&Su, JC.(2017).Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material.SCIENTIFIC REPORTS,7,-.
MLA Wang, ZW,et al."Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material".SCIENTIFIC REPORTS 7(2017):-.
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