Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material

doi:10.1038/s41598-017-00905-2

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material
	Wang, ZW; Ma, YH; Wei, J; Chen, X; Cao, LH; Weng, WZ; Li, Q; Guo, H; Su, JC
	2017
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	7 页码:-
文章类型	期刊论文
摘要	Magnesium phosphate (MP) was fabricated using a chemical precipitation method, and the biological performances of MP sintered at different temperatures as a biomedical material was investigated. The results indicated that the densification and crystallinity of MP increased as the sintering temperature increased. As the sintering temperature increased, the degradability of MP in PBS decreased, and the mineralization ability in SBF significantly increased. In addition, the MP sintered at 800 degrees C (MP8) possessed the lowest degradability and highest mineralization ability. Moreover, the positive response of MG63 cells to MP significantly increased as the sintering temperature increased, and MP8 significantly promoted the cell spreading, proliferation, differentiation and expressions of osteogenic differentiation-related genes. Faster degradation of MP0 resulted in higher pH environments and ion concentrations, which led to negative responses to osteoblasts. However, the appropriate degradation of MP8 resulted in suitable pH environments and ion concentrations, which led to positive responses to osteoblasts. This study demonstrated that the sintering temperature substantially affected the surface morphology/microstructure, degradability and mineralization, and osteoblasts response to magnesium phosphate.
DOI	10.1038/s41598-017-00905-2
收录类别	SCI
语种	英语
WOS记录号	WOS:000398824300040
引用统计
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/27306
专题	中科院上海应用物理研究所2011-2018年
推荐引用方式 GB/T 7714	Wang, ZW,Ma, YH,Wei, J,et al. Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material[J]. SCIENTIFIC REPORTS,2017,7:-.
APA	Wang, ZW.,Ma, YH.,Wei, J.,Chen, X.,Cao, LH.,...&Su, JC.(2017).Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material.SCIENTIFIC REPORTS,7,-.
MLA	Wang, ZW,et al."Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material".SCIENTIFIC REPORTS 7(2017):-.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Effects of sintering（3167KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	请求全文