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题名:
In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles
作者: Li, R; Wu, GZ; Cai, XM; Ye, Y
刊名: RADIATION PHYSICS AND CHEMISTRY
出版日期: 2017
卷号: 134, 页码:27-32
关键词: gamma-ray simultaneous irradiation induced graft ; polymerization ; Poly(vinyl alcohol) ; Acrylic acid ; Sodium styrenesulfonate ; Anticoagulant activity
DOI: 10.1016/j.radphyschem.2017.01.006
文章类型: 期刊论文
英文摘要: Poly(acrylic acid), poly(sodium styrenesulfonate), and poly(acrylic acid-co-sodium styrenesulfonate) chains were immobilized onto poly(vinyl alcohol) (PVA) particles via a facile gamma-ray simultaneous irradiation induced graft polymerization technique, which were confirmed by the attenuated total reflection Fourier transform infrared spectroscopy and the high swelling ratios of modified PVA particles. The effects of absorbed dose, dose rate, Cu2+ concentration and monomer concentration on the degree of grafting (DG) of PVA particles were investigated to find out a feasible process for preparing polyanionic chains graft-modified PVA particles. The clotting time results illustrated that both PVA-g-PAA and PVA-g-PSSS particles presented excellent anticoagulant activity, and the activated partial thromboplastin time (APTI), prothrombin time (PT) and thrombin time (TT) were effectively prolonged with the increase of DG(AA) and DG(sss), respectively. Furthermore, the anticoagulant activity of PVA-g-PSSS samples was more efficient than that of PVA-g-PAA samples. However, the anticoagulant effect of PVA-g-P(AA-co-SSS) samples was different from that of PVA-g-PAA and PVA-g-PSSS samples, and was similar to that of heparin, mainly elongating the APTT and TT. This might be due to both of them containing the same negative-charged groups. Additionally, the grafted PVA particles were all non hemolytic, showing good blood compatibility.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000395607900005
ISSN号: 0969-806X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/27349
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Li, R,Wu, GZ,Cai, XM,et al. In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles[J]. RADIATION PHYSICS AND CHEMISTRY,2017-01-01,134:27-32.
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文件名: In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles.pdf
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