In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles

doi:10.1016/j.radphyschem.2017.01.006

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles
	Li, R; Wu, GZ; Cai, XM; Ye, Y
	2017
发表期刊	RADIATION PHYSICS AND CHEMISTRY
ISSN	0969-806X
卷号	134 页码:27-32
文章类型	期刊论文
摘要	Poly(acrylic acid), poly(sodium styrenesulfonate), and poly(acrylic acid-co-sodium styrenesulfonate) chains were immobilized onto poly(vinyl alcohol) (PVA) particles via a facile gamma-ray simultaneous irradiation induced graft polymerization technique, which were confirmed by the attenuated total reflection Fourier transform infrared spectroscopy and the high swelling ratios of modified PVA particles. The effects of absorbed dose, dose rate, Cu2+ concentration and monomer concentration on the degree of grafting (DG) of PVA particles were investigated to find out a feasible process for preparing polyanionic chains graft-modified PVA particles. The clotting time results illustrated that both PVA-g-PAA and PVA-g-PSSS particles presented excellent anticoagulant activity, and the activated partial thromboplastin time (APTI), prothrombin time (PT) and thrombin time (TT) were effectively prolonged with the increase of DG(AA) and DG(sss), respectively. Furthermore, the anticoagulant activity of PVA-g-PSSS samples was more efficient than that of PVA-g-PAA samples. However, the anticoagulant effect of PVA-g-P(AA-co-SSS) samples was different from that of PVA-g-PAA and PVA-g-PSSS samples, and was similar to that of heparin, mainly elongating the APTT and TT. This might be due to both of them containing the same negative-charged groups. Additionally, the grafted PVA particles were all non hemolytic, showing good blood compatibility.
关键词	Gamma-ray Simultaneous Irradiation Induced Graft Polymerization Poly(Vinyl Alcohol) Acrylic Acid Sodium Styrenesulfonate Anticoagulant Activity
DOI	10.1016/j.radphyschem.2017.01.006
收录类别	SCI
语种	英语
WOS记录号	WOS:000395607900005
引用统计
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/27349
专题	中科院上海应用物理研究所2011-2018年
推荐引用方式 GB/T 7714	Li, R,Wu, GZ,Cai, XM,et al. In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles[J]. RADIATION PHYSICS AND CHEMISTRY,2017,134:27-32.
APA	Li, R,Wu, GZ,Cai, XM,&Ye, Y.(2017).In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles.RADIATION PHYSICS AND CHEMISTRY,134,27-32.
MLA	Li, R,et al."In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles".RADIATION PHYSICS AND CHEMISTRY 134(2017):27-32.

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