CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles
Li, R; Wu, GZ; Cai, XM; Ye, Y
2017
Source PublicationRADIATION PHYSICS AND CHEMISTRY
ISSN0969-806X
Volume134Pages:27-32
Subtype期刊论文
AbstractPoly(acrylic acid), poly(sodium styrenesulfonate), and poly(acrylic acid-co-sodium styrenesulfonate) chains were immobilized onto poly(vinyl alcohol) (PVA) particles via a facile gamma-ray simultaneous irradiation induced graft polymerization technique, which were confirmed by the attenuated total reflection Fourier transform infrared spectroscopy and the high swelling ratios of modified PVA particles. The effects of absorbed dose, dose rate, Cu2+ concentration and monomer concentration on the degree of grafting (DG) of PVA particles were investigated to find out a feasible process for preparing polyanionic chains graft-modified PVA particles. The clotting time results illustrated that both PVA-g-PAA and PVA-g-PSSS particles presented excellent anticoagulant activity, and the activated partial thromboplastin time (APTI), prothrombin time (PT) and thrombin time (TT) were effectively prolonged with the increase of DG(AA) and DG(sss), respectively. Furthermore, the anticoagulant activity of PVA-g-PSSS samples was more efficient than that of PVA-g-PAA samples. However, the anticoagulant effect of PVA-g-P(AA-co-SSS) samples was different from that of PVA-g-PAA and PVA-g-PSSS samples, and was similar to that of heparin, mainly elongating the APTT and TT. This might be due to both of them containing the same negative-charged groups. Additionally, the grafted PVA particles were all non hemolytic, showing good blood compatibility.
KeywordGamma-ray Simultaneous Irradiation Induced Graft Polymerization Poly(Vinyl Alcohol) Acrylic Acid Sodium Styrenesulfonate Anticoagulant Activity
DOI10.1016/j.radphyschem.2017.01.006
Indexed BySCI
Language英语
WOS IDWOS:000395607900005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/27349
Collection中科院上海应用物理研究所2011-2018年
Recommended Citation
GB/T 7714
Li, R,Wu, GZ,Cai, XM,et al. In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles[J]. RADIATION PHYSICS AND CHEMISTRY,2017,134:27-32.
APA Li, R,Wu, GZ,Cai, XM,&Ye, Y.(2017).In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles.RADIATION PHYSICS AND CHEMISTRY,134,27-32.
MLA Li, R,et al."In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles".RADIATION PHYSICS AND CHEMISTRY 134(2017):27-32.
Files in This Item: Download All
File Name/Size DocType Version Access License
In vitro anticoagula(468KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, R]'s Articles
[Wu, GZ]'s Articles
[Cai, XM]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, R]'s Articles
[Wu, GZ]'s Articles
[Cai, XM]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, R]'s Articles
[Wu, GZ]'s Articles
[Cai, XM]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.