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题名:
Multicolor Gold Silver Nano-Mushrooms as Ready-to-Use SERS Probes for Ultrasensitive and Multiplex DNA/miRNA Detection
作者: Su, J; Wang, DF; Norbel, L; Shen, JL; Zhao, ZH; Dou, YZ; Peng, TH; Shi, JY; Mathur, S; Fan, CH; Song, SP
刊名: ANALYTICAL CHEMISTRY
出版日期: 2017
卷号: 89, 期号:4, 页码:2531-2538
DOI: 10.1021/acs.analchem.6b04729
文章类型: 期刊论文
英文摘要: Uniform silver-containing metal nanostructures with strong and stable surface enhanced Raman scattering (SERS) signals hold great promise for developing ultrasensitive probes for biodetection. Nevertheless, the direct synthesis of such ready-to-use nanoprobes remains extremely challenging. Herein we report a DNA-mediated gold silver nanomushroom with interior nanogaps directly synthesized and used for multiplex and simultaneous SERS detection of various DNA and RNA targets. The DNA involved in the nanostructures can act as hot only gap DNA (mediated DNA) but also probe DNA (hybridized DNA), and DNA's involvement enables the nanostructures to have the inherent ability to recognize DNA and RNA targets. Importantly, we were the first to establish a new method for the generation of multicolor SERS probes using two different strategies. First Raman-labeled alkanethiol probe DNA was assembled on gold nanoparticles, and second, thiol-containing Raman reporters were coassembled with the probe DNA. The ready-to-use probes also give great potential to develop ultrasensitive detection methods for various biological molecules.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000394724700050
ISSN号: 0003-2700
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/27389
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Su, J,Wang, DF,Norbel, L,et al. Multicolor Gold Silver Nano-Mushrooms as Ready-to-Use SERS Probes for Ultrasensitive and Multiplex DNA/miRNA Detection[J]. ANALYTICAL CHEMISTRY,2017-01-01,89(4):2531-2538.
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