Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Multicolor Gold Silver Nano-Mushrooms as Ready-to-Use SERS Probes for Ultrasensitive and Multiplex DNA/miRNA Detection | |
| Su, J; Wang, DF; Norbel, L; Shen, JL; Zhao, ZH; Dou, YZ; Peng, TH; Shi, JY; Mathur, S; Fan, CH; Song, SP | |
| 2017 | |
| Source Publication | ANALYTICAL CHEMISTRY
 |
| ISSN | 0003-2700 |
| Volume | 89Issue:4Pages:2531-2538 |
| Subtype | 期刊论文 |
| Abstract | Uniform silver-containing metal nanostructures with strong and stable surface enhanced Raman scattering (SERS) signals hold great promise for developing ultrasensitive probes for biodetection. Nevertheless, the direct synthesis of such ready-to-use nanoprobes remains extremely challenging. Herein we report a DNA-mediated gold silver nanomushroom with interior nanogaps directly synthesized and used for multiplex and simultaneous SERS detection of various DNA and RNA targets. The DNA involved in the nanostructures can act as hot only gap DNA (mediated DNA) but also probe DNA (hybridized DNA), and DNA's involvement enables the nanostructures to have the inherent ability to recognize DNA and RNA targets. Importantly, we were the first to establish a new method for the generation of multicolor SERS probes using two different strategies. First Raman-labeled alkanethiol probe DNA was assembled on gold nanoparticles, and second, thiol-containing Raman reporters were coassembled with the probe DNA. The ready-to-use probes also give great potential to develop ultrasensitive detection methods for various biological molecules. |
| DOI | 10.1021/acs.analchem.6b04729 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000394724700050 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/27389 |
| Collection | 中科院上海应用物理研究所2011-2018年 |
| Recommended Citation GB/T 7714 | Su, J,Wang, DF,Norbel, L,et al. Multicolor Gold Silver Nano-Mushrooms as Ready-to-Use SERS Probes for Ultrasensitive and Multiplex DNA/miRNA Detection[J]. ANALYTICAL CHEMISTRY,2017,89(4):2531-2538. |
| APA | Su, J.,Wang, DF.,Norbel, L.,Shen, JL.,Zhao, ZH.,...&Song, SP.(2017).Multicolor Gold Silver Nano-Mushrooms as Ready-to-Use SERS Probes for Ultrasensitive and Multiplex DNA/miRNA Detection.ANALYTICAL CHEMISTRY,89(4),2531-2538. |
| MLA | Su, J,et al."Multicolor Gold Silver Nano-Mushrooms as Ready-to-Use SERS Probes for Ultrasensitive and Multiplex DNA/miRNA Detection".ANALYTICAL CHEMISTRY 89.4(2017):2531-2538. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Multicolor Gold Silv（6018KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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