Multicolor Gold Silver Nano-Mushrooms as Ready-to-Use SERS Probes for Ultrasensitive and Multiplex DNA/miRNA Detection

doi:10.1021/acs.analchem.6b04729

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	Multicolor Gold Silver Nano-Mushrooms as Ready-to-Use SERS Probes for Ultrasensitive and Multiplex DNA/miRNA Detection
	Su, J; Wang, DF; Norbel, L; Shen, JL; Zhao, ZH; Dou, YZ; Peng, TH; Shi, JY; Mathur, S; Fan, CH; Song, SP
	2017
发表期刊	ANALYTICAL CHEMISTRY
ISSN	0003-2700
卷号	89 期号:4 页码:2531-2538
文章类型	期刊论文
摘要	Uniform silver-containing metal nanostructures with strong and stable surface enhanced Raman scattering (SERS) signals hold great promise for developing ultrasensitive probes for biodetection. Nevertheless, the direct synthesis of such ready-to-use nanoprobes remains extremely challenging. Herein we report a DNA-mediated gold silver nanomushroom with interior nanogaps directly synthesized and used for multiplex and simultaneous SERS detection of various DNA and RNA targets. The DNA involved in the nanostructures can act as hot only gap DNA (mediated DNA) but also probe DNA (hybridized DNA), and DNA's involvement enables the nanostructures to have the inherent ability to recognize DNA and RNA targets. Importantly, we were the first to establish a new method for the generation of multicolor SERS probes using two different strategies. First Raman-labeled alkanethiol probe DNA was assembled on gold nanoparticles, and second, thiol-containing Raman reporters were coassembled with the probe DNA. The ready-to-use probes also give great potential to develop ultrasensitive detection methods for various biological molecules.
DOI	10.1021/acs.analchem.6b04729
收录类别	SCI
语种	英语
WOS记录号	WOS:000394724700050
引用统计
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/27389
专题	中科院上海应用物理研究所2011-2018年
推荐引用方式 GB/T 7714	Su, J,Wang, DF,Norbel, L,et al. Multicolor Gold Silver Nano-Mushrooms as Ready-to-Use SERS Probes for Ultrasensitive and Multiplex DNA/miRNA Detection[J]. ANALYTICAL CHEMISTRY,2017,89(4):2531-2538.
APA	Su, J.,Wang, DF.,Norbel, L.,Shen, JL.,Zhao, ZH.,...&Song, SP.(2017).Multicolor Gold Silver Nano-Mushrooms as Ready-to-Use SERS Probes for Ultrasensitive and Multiplex DNA/miRNA Detection.ANALYTICAL CHEMISTRY,89(4),2531-2538.
MLA	Su, J,et al."Multicolor Gold Silver Nano-Mushrooms as Ready-to-Use SERS Probes for Ultrasensitive and Multiplex DNA/miRNA Detection".ANALYTICAL CHEMISTRY 89.4(2017):2531-2538.

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Multicolor Gold Silv（6018KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	请求全文