Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo
Yi, HY; Li, XJ; Wang, ZY; Yin, M; Wang, LH; Aldalbahi, A; El-Sayed, NN; Wang, H; Chen, N; Chen, LN; Fan, CH; Song, HY
2017
发表期刊PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
ISSN0934-0866
卷号34期号:1页码:-
文章类型期刊论文
摘要Biocompatible nanoparticles hold a great promise for biomedical applications, whereas their biosafety has raised extensive concerns. Nanodiamonds (NDs) are generally regarded as inert nanocarriers and widely employed in biomedical studies; however, it is yet to explore their biological effects in more general contexts. In this study, the authors observe that intracellular NDs block signal transduction of the Wnt signaling pathway, an effect that is not caused by general cytotoxicity. The authors find that NDs attenuate activities of Wnt signaling in several types of cell lines and in Zebrafish, and interfere with Wnt signaling-controlled biological processes, including cancer cell migration, adipocyte differentiation, and embryonic development. Significantly, the authors show that intracellular NDs trigger degradation of the disheveled protein, a key component of Wnt signaling cascade, while they do not affect protein stability of other Wnt signal transducers or other signaling molecules. This work thus illustrates a novel crosstalk between nanoparticles and the Wnt signaling pathway, and expands the understanding of biological effects induced by nanoparticles. In addition, given the clinical implications of Wnt signaling in tumorigenesis and cancer metastasis, this study also provides the rationale for potential applications of NDs in cancer therapies.
关键词Cancer Cell Migration Embryonic Development Nanodiamonds Obesity Signal Transduction
DOI10.1002/ppsc.201600208
收录类别SCI
语种英语
WOS记录号WOS:000393580600007
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/27391
专题中科院上海应用物理研究所2011-2018年
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Yi, HY,Li, XJ,Wang, ZY,et al. Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2017,34(1):-.
APA Yi, HY.,Li, XJ.,Wang, ZY.,Yin, M.,Wang, LH.,...&Song, HY.(2017).Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo.PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,34(1),-.
MLA Yi, HY,et al."Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 34.1(2017):-.
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