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题名:
Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo
作者: Yi, HY; Li, XJ; Wang, ZY; Yin, M; Wang, LH; Aldalbahi, A; El-Sayed, NN; Wang, H; Chen, N; Chen, LN; Fan, CH; Song, HY
刊名: PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
出版日期: 2017
卷号: 34, 期号:1, 页码:-
关键词: cancer cell migration ; embryonic development ; nanodiamonds ; obesity ; signal transduction
DOI: 10.1002/ppsc.201600208
文章类型: 期刊论文
英文摘要: Biocompatible nanoparticles hold a great promise for biomedical applications, whereas their biosafety has raised extensive concerns. Nanodiamonds (NDs) are generally regarded as inert nanocarriers and widely employed in biomedical studies; however, it is yet to explore their biological effects in more general contexts. In this study, the authors observe that intracellular NDs block signal transduction of the Wnt signaling pathway, an effect that is not caused by general cytotoxicity. The authors find that NDs attenuate activities of Wnt signaling in several types of cell lines and in Zebrafish, and interfere with Wnt signaling-controlled biological processes, including cancer cell migration, adipocyte differentiation, and embryonic development. Significantly, the authors show that intracellular NDs trigger degradation of the disheveled protein, a key component of Wnt signaling cascade, while they do not affect protein stability of other Wnt signal transducers or other signaling molecules. This work thus illustrates a novel crosstalk between nanoparticles and the Wnt signaling pathway, and expands the understanding of biological effects induced by nanoparticles. In addition, given the clinical implications of Wnt signaling in tumorigenesis and cancer metastasis, this study also provides the rationale for potential applications of NDs in cancer therapies.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000393580600007
ISSN号: 0934-0866
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/27391
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Yi, HY,Li, XJ,Wang, ZY,et al. Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2017-01-01,34(1):-.
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