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Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo
Yi, HY; Li, XJ; Wang, ZY; Yin, M; Wang, LH; Aldalbahi, A; El-Sayed, NN; Wang, H; Chen, N; Chen, LN; Fan, CH; Song, HY
2017
Source PublicationPARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
ISSN0934-0866
Volume34Issue:1Pages:-
Subtype期刊论文
AbstractBiocompatible nanoparticles hold a great promise for biomedical applications, whereas their biosafety has raised extensive concerns. Nanodiamonds (NDs) are generally regarded as inert nanocarriers and widely employed in biomedical studies; however, it is yet to explore their biological effects in more general contexts. In this study, the authors observe that intracellular NDs block signal transduction of the Wnt signaling pathway, an effect that is not caused by general cytotoxicity. The authors find that NDs attenuate activities of Wnt signaling in several types of cell lines and in Zebrafish, and interfere with Wnt signaling-controlled biological processes, including cancer cell migration, adipocyte differentiation, and embryonic development. Significantly, the authors show that intracellular NDs trigger degradation of the disheveled protein, a key component of Wnt signaling cascade, while they do not affect protein stability of other Wnt signal transducers or other signaling molecules. This work thus illustrates a novel crosstalk between nanoparticles and the Wnt signaling pathway, and expands the understanding of biological effects induced by nanoparticles. In addition, given the clinical implications of Wnt signaling in tumorigenesis and cancer metastasis, this study also provides the rationale for potential applications of NDs in cancer therapies.
KeywordCancer Cell Migration Embryonic Development Nanodiamonds Obesity Signal Transduction
DOI10.1002/ppsc.201600208
Indexed BySCI
Language英语
WOS IDWOS:000393580600007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/27391
Collection中科院上海应用物理研究所2011-2018年
Recommended Citation
GB/T 7714
Yi, HY,Li, XJ,Wang, ZY,et al. Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2017,34(1):-.
APA Yi, HY.,Li, XJ.,Wang, ZY.,Yin, M.,Wang, LH.,...&Song, HY.(2017).Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo.PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,34(1),-.
MLA Yi, HY,et al."Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 34.1(2017):-.
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