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CAS OpenIR  > 中科院上海应用物理研究所2011-2017年  > 期刊论文
题名:
Neovascularization of hepatocellular carcinoma in a nude mouse orthotopic liver cancer model: a morphological study using X-ray in-line phase-contrast imaging
作者: Li, BL; Zhang, YQ; Wu, WZ; Du, GH; Cai, L; Shi, HC; Chen, SL
刊名: BMC CANCER
出版日期: 2017
卷号: 17, 页码:-
关键词: Synchrotron radiation ; In-line phase-contrast imaging ; Computed tomography ; Hepatocellular carcinoma ; Tumor neovascularization
DOI: 10.1186/s12885-017-3073-3
文章类型: 期刊论文
英文摘要: Background: This study aimed to determine whether synchrotron radiation (SR)-based X-ray in-line phase-contrast imaging (IL-PCI) can be used to investigate the morphological characteristics of tumor neovascularization in a liver xenograft animal model. Methods: A human hepatocellular carcinoma HCCLM3 xenograft model was established in nude mice. Xenografts were sampled each week for 4 weeks and fixed to analyze tissue characteristics and neovascularization using SR-based X-ray in-line phase contrast computed tomography (IL-XPCT) without any contrast agent. Results: The effect of the energy level and object-to-detector distance on phase-contrast difference was in good agreement with the theory of IL-PCI. Boundaries between the tumor and adjacent normal tissues at week 1 were clearly observed in two-dimensional phase contrast projection imaging. A quantitative contrast difference was observed from weeks 1 to 4. Moreover, 3D image reconstruction of hepatocellular carcinoma (HCC) samples showed blood vessels inside the tumor were abnormal. The smallest blood vessels measured approximately 20 mu m in diameter. The tumor vascular density initially increased and then decreased gradually over time. The maximum tumor vascular density was 4.29% at week 2. Conclusion: IL-XPCT successfully acquired images of neovascularization in HCC xenografts in nude mice.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000393840200001
ISSN号: 1471-2407
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/27393
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Li, BL,Zhang, YQ,Wu, WZ,et al. Neovascularization of hepatocellular carcinoma in a nude mouse orthotopic liver cancer model: a morphological study using X-ray in-line phase-contrast imaging[J]. BMC CANCER,2017-01-01,17:-.
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文件名: Neovascularization of hepatocellular carcinoma in a nude mouse orthotopic liver cancer model.pdf
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