Optimal Hotspots of Dynamic Surfaced-Enhanced Raman Spectroscopy for Drugs Quantitative Detection
Yan, XN; Li, P; Zhou, BB; Tang, XH; Li, XY; Weng, SZ; Yang, LB; Liu, JH
2017
发表期刊ANALYTICAL CHEMISTRY
ISSN0003-2700
卷号89期号:9页码:4875-4881
文章类型期刊论文
摘要Surface-enhanced Raman spectroscopy (SERS) as a powerful qualitative analysis method has been widely applied in many fields. However, SERS for quantitative analysis still suffers from several challenges partially because of the absence of stable and credible analytical strategy. Here, we demonstrate that the optimal hotspots created from dynamic surfaced-enhanced Raman spectroscopy (D-SERS) can be used for quantitative SERS measurements. In situ small-angle X-ray scattering was carried out to in situ real-time monitor the formation of the optimal hotspots, where the optimal hotspots with the most efficient hotspots were generated during the monodisperse Au-sol evaporating process. Importantly, the natural evaporation of Au-sol avoids the nanoparticles instability of salt-induced, and formation of ordered three-dimensional hotspots allows SERS detection with excellent reproducibility. Considering SERS signal variability in the D-SERS process, 4-mercaptopyridine (4-mpy) acted as internal standard to validly correct and improve stability as well as reduce fluctuation of signals. The strongest SERS spectra at the optimal hotspots of D-SERS have been extracted to statistics analysis. By using the SERS signal of 4-mpy as a stable internal calibration standard, the relative SERS intensity of target molecules demonstrated a linear response versus the negative logarithm of concentrations at the point of strongest SERS signals, which illustrates the great potential for quantitative analysis. The public drugs 3,4-methylenedioxymethamphetamine and alpha-methyltryptamine hydrochloride obtained precise analysis with internal standard D-SERS strategy. As a consequence, one has reason to believe our approach is promising to challenge quantitative problems in conventional SERS analysis.
DOI10.1021/acs.analchem.6b04688
收录类别SCI
语种英语
WOS记录号WOS:000400723600019
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/27401
专题中科院上海应用物理研究所2011-2018年
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Yan, XN,Li, P,Zhou, BB,et al. Optimal Hotspots of Dynamic Surfaced-Enhanced Raman Spectroscopy for Drugs Quantitative Detection[J]. ANALYTICAL CHEMISTRY,2017,89(9):4875-4881.
APA Yan, XN.,Li, P.,Zhou, BB.,Tang, XH.,Li, XY.,...&Liu, JH.(2017).Optimal Hotspots of Dynamic Surfaced-Enhanced Raman Spectroscopy for Drugs Quantitative Detection.ANALYTICAL CHEMISTRY,89(9),4875-4881.
MLA Yan, XN,et al."Optimal Hotspots of Dynamic Surfaced-Enhanced Raman Spectroscopy for Drugs Quantitative Detection".ANALYTICAL CHEMISTRY 89.9(2017):4875-4881.
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