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题名:
Radical-Induced Degradation of Fluoxetine in Aqueous Solution by Pulse and Steady-State Radiolysis Studies
作者: Ji, TY; Liu, YC; Zhao, JF; Xu, G; Wang, WF; Wu, MH
刊名: ACTA PHYSICO-CHIMICA SINICA
出版日期: 2017
卷号: 33, 期号:4, 页码:823-828
关键词: Fluoxetine ; Pulse radiolysis ; Hydroxyl radical ; Sulfate radical anion ; Degradation
DOI: 10.3866/PKU.WHXB201701092
文章类型: 期刊论文
英文摘要: The reactions of the pharmaceutical fluoxetine (FLX) with different radicals were investigated by pulse radiolysis. The reaction of hydroxyl radical (center dot OH) with FLX formed hydroxylated adduct of the aromatic ring, while oxidation of FLX by sulfate radical anion (SO4 center dot-) formed benzene radical cation that further reacted with H2O to yield the center dot OH adduct. The determined rate constants of center dot OH, hydrated electrons (e(aq)(-)), and SO4 center dot- with FLX were 7.8 x 10(9), 2.3 x 10(9), and 1.1 x 10(9) mol.L-1.s(-1), respectively. In the steady-state radiolysis study, the degradation of FLX in different radiolytic conditions by electron beam irradiation was detected by HPLC and UV-Vis spectra techniques. It was found that FLX concentration decreased by more than 90% in both N2O and air-saturated solutions after 1.5 kGy irradiation. In contrast, only 43% of FLX was decomposed in N-2-saturated solution containing 0.1 mol.L-1 tert-butanol. The degradation rates of FLX in acidic and neutral solutions were higher than those in alkaline solutions. Our results showed that the degradation of FLX is optimal in air-saturated neutral solution, and center dot OH-induced degradation is more efficient than SO4 center dot- oxidation of FLX. The obtained kinetic data and optimal conditions give some hints to understand the degradation of FLX.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000400025000024
ISSN号: 1000-6818
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/27429
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Ji, TY,Liu, YC,Zhao, JF,et al. Radical-Induced Degradation of Fluoxetine in Aqueous Solution by Pulse and Steady-State Radiolysis Studies[J]. ACTA PHYSICO-CHIMICA SINICA,2017-01-01,33(4):823-828.
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