CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Radical-Induced Degradation of Fluoxetine in Aqueous Solution by Pulse and Steady-State Radiolysis Studies
Ji, TY; Liu, YC; Zhao, JF; Xu, G; Wang, WF; Wu, MH
2017
Source PublicationACTA PHYSICO-CHIMICA SINICA
ISSN1000-6818
Volume33Issue:4Pages:823-828
Subtype期刊论文
AbstractThe reactions of the pharmaceutical fluoxetine (FLX) with different radicals were investigated by pulse radiolysis. The reaction of hydroxyl radical (center dot OH) with FLX formed hydroxylated adduct of the aromatic ring, while oxidation of FLX by sulfate radical anion (SO4 center dot-) formed benzene radical cation that further reacted with H2O to yield the center dot OH adduct. The determined rate constants of center dot OH, hydrated electrons (e(aq)(-)), and SO4 center dot- with FLX were 7.8 x 10(9), 2.3 x 10(9), and 1.1 x 10(9) mol.L-1.s(-1), respectively. In the steady-state radiolysis study, the degradation of FLX in different radiolytic conditions by electron beam irradiation was detected by HPLC and UV-Vis spectra techniques. It was found that FLX concentration decreased by more than 90% in both N2O and air-saturated solutions after 1.5 kGy irradiation. In contrast, only 43% of FLX was decomposed in N-2-saturated solution containing 0.1 mol.L-1 tert-butanol. The degradation rates of FLX in acidic and neutral solutions were higher than those in alkaline solutions. Our results showed that the degradation of FLX is optimal in air-saturated neutral solution, and center dot OH-induced degradation is more efficient than SO4 center dot- oxidation of FLX. The obtained kinetic data and optimal conditions give some hints to understand the degradation of FLX.
KeywordFluoxetine Pulse Radiolysis Hydroxyl Radical Sulfate Radical Anion Degradation
DOI10.3866/PKU.WHXB201701092
Indexed BySCI
Language英语
WOS IDWOS:000400025000024
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/27429
Collection中科院上海应用物理研究所2011-2018年
Recommended Citation
GB/T 7714
Ji, TY,Liu, YC,Zhao, JF,et al. Radical-Induced Degradation of Fluoxetine in Aqueous Solution by Pulse and Steady-State Radiolysis Studies[J]. ACTA PHYSICO-CHIMICA SINICA,2017,33(4):823-828.
APA Ji, TY,Liu, YC,Zhao, JF,Xu, G,Wang, WF,&Wu, MH.(2017).Radical-Induced Degradation of Fluoxetine in Aqueous Solution by Pulse and Steady-State Radiolysis Studies.ACTA PHYSICO-CHIMICA SINICA,33(4),823-828.
MLA Ji, TY,et al."Radical-Induced Degradation of Fluoxetine in Aqueous Solution by Pulse and Steady-State Radiolysis Studies".ACTA PHYSICO-CHIMICA SINICA 33.4(2017):823-828.
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