Reactions of Triplet-State Difloxacin with Amino Acids and dGMP: A Laser Flash Photolysis Study

doi:10.3866/PKU.WHXB201702201

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	Reactions of Triplet-State Difloxacin with Amino Acids and dGMP: A Laser Flash Photolysis Study
	Li, HX; Liu, YC; Tang, RZ; Zhang, P; Ma, LK; Wei, CY; Wang, WF
	2017
发表期刊	ACTA PHYSICO-CHIMICA SINICA
ISSN	1000-6818
卷号	33 期号:5 页码:1051-1056
文章类型	期刊论文
摘要	The reactions of triplet-state difloxacin (DFX) with various amino acids and deoxyguanylic acid in aqueous media were studied using laser flash photolysis. Tryptophan, tyrosine, cysteine, and 2'-deoxyguanosine5'-monophosphate (dGMP) were found to completely quench the triplet state of DFX in aqueous solution, the corresponding second-order rate constants being 1.97 x 10(8), 1.48 x 10(8), 1.72 x 10(8), and 6.92 x 10(7) dm(3).mol(-l).s(-1) . The quenching mechanism involves electron transfer to the photoexcited triplet state of DFX from the tryptophan, tyrosine, cysteine, and dGMP moieties, followed by fast protonation of the resulting DFX anion radical.
关键词	Laser Flash Photolysis Difloxacin Triplet State Amino Acid
DOI	10.3866/PKU.WHXB201702201
收录类别	SCI
语种	英语
WOS记录号	WOS:000401878800027
引用统计
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/27431
专题	中科院上海应用物理研究所2011-2018年
推荐引用方式 GB/T 7714	Li, HX,Liu, YC,Tang, RZ,et al. Reactions of Triplet-State Difloxacin with Amino Acids and dGMP: A Laser Flash Photolysis Study[J]. ACTA PHYSICO-CHIMICA SINICA,2017,33(5):1051-1056.
APA	Li, HX.,Liu, YC.,Tang, RZ.,Zhang, P.,Ma, LK.,...&Wang, WF.(2017).Reactions of Triplet-State Difloxacin with Amino Acids and dGMP: A Laser Flash Photolysis Study.ACTA PHYSICO-CHIMICA SINICA,33(5),1051-1056.
MLA	Li, HX,et al."Reactions of Triplet-State Difloxacin with Amino Acids and dGMP: A Laser Flash Photolysis Study".ACTA PHYSICO-CHIMICA SINICA 33.5(2017):1051-1056.

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