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题名:
Stable Nanocomposite Based on PEGylated and Silver Nanoparticles Loaded Graphene Oxide for Long-Term Antibacterial Activity
作者: Zhao, RT; Lv, M; Li, Y; Sun, MX; Kong, W; Wang, LH; Song, SP; Fan, CH; Jia, LL; Qiu, SF; Sun, YS; Song, HB; Hao, RZ
刊名: ACS APPLIED MATERIALS & INTERFACES
出版日期: 2017
卷号: 9, 期号:18, 页码:15328-15341
关键词: graphene oxide ; PEGylation ; silver nanoparticles ; antibacterial activity ; antibiotic resistance ; stability ; long-term effectiveness
DOI: 10.1021/acsami.7b03987
文章类型: 期刊论文
英文摘要: The increasing occurrence of antibiotic-resistant pathogens, especially superbugs, is compromising the efficacy of traditional antibiotics. Silver nanoparticles (AgNPs) loaded graphene oxide (GO) nanocomposite (GO-Ag) has drawn great interest as a promising alternative antibacterial material. However, GO-Ag nanocomposite often irreversibly aggregates in physiological solutions, severely influencing its antibacterial capacity and practical application. Herein, a PEGylated and AgNPs loaded GO nanocomposite (GOPEG-Ag) is synthesized through a facile approach utilizing microwave irradiation, while avoiding extra reducing agents. Through PEGylation, the synthesized GO-PEG-Ag nano composite dispersed stably over one month in a series of media and resisted centrifugation at 10 000xg for 5 min, which would benefit effective contact between the nanocomposite and the bacteria. In contrast, GO-Ag aggregated within 1 h of dispersion in physiological solutions. In comparison with GO-Ag, GO-PEG-Ag showed stronger bactericidal capability toward not only normal Gram-negative/positive bacteria such as E. coli and S. aureus (similar to 100% of E. coli and similar to 95.3% of S. aureus reduction by 10 mu g/mL nanocomposite for 2.5 h), but also superbugs. Moreover, GO-PEG-Ag showed lower cytotoxicity toward HeLa cells. Importantly, GO-PEG-Ag presented long-term antibacterial effectiveness, remaining similar to 95% antibacterial activity after one-week storage in saline solution versus <35% for GO-Ag. The antibacterial mechanisms of GO-PEG-Ag were evidenced as damage to the bacterial structure and production of reactive oxygen species, causing cytoplasm leakage and metabolism decrease. The stable GO-PEG-Ag nanocomposite with powerful and long-term antibacterial capability provides a more practical and effective strategy for fighting superbugs-including pathogen threats in biomedicine and public health.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000401307100013
ISSN号: 1944-8244
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/27448
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Zhao, RT,Lv, M,Li, Y,et al. Stable Nanocomposite Based on PEGylated and Silver Nanoparticles Loaded Graphene Oxide for Long-Term Antibacterial Activity[J]. ACS APPLIED MATERIALS & INTERFACES,2017-01-01,9(18):15328-15341.
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文件名: Stable Nanocomposite Based on PEGylated and Silver Nanoparticles Loaded Graphene Oxide for Long-Term Antibacterial Activity.pdf
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