Stable Nanocomposite Based on PEGylated and Silver Nanoparticles Loaded Graphene Oxide for Long-Term Antibacterial Activity
Zhao, RT; Lv, M; Li, Y; Sun, MX; Kong, W; Wang, LH; Song, SP; Fan, CH; Jia, LL; Qiu, SF; Sun, YS; Song, HB; Hao, RZ
2017
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号9期号:18页码:15328-15341
文章类型期刊论文
摘要The increasing occurrence of antibiotic-resistant pathogens, especially superbugs, is compromising the efficacy of traditional antibiotics. Silver nanoparticles (AgNPs) loaded graphene oxide (GO) nanocomposite (GO-Ag) has drawn great interest as a promising alternative antibacterial material. However, GO-Ag nanocomposite often irreversibly aggregates in physiological solutions, severely influencing its antibacterial capacity and practical application. Herein, a PEGylated and AgNPs loaded GO nanocomposite (GOPEG-Ag) is synthesized through a facile approach utilizing microwave irradiation, while avoiding extra reducing agents. Through PEGylation, the synthesized GO-PEG-Ag nano composite dispersed stably over one month in a series of media and resisted centrifugation at 10 000xg for 5 min, which would benefit effective contact between the nanocomposite and the bacteria. In contrast, GO-Ag aggregated within 1 h of dispersion in physiological solutions. In comparison with GO-Ag, GO-PEG-Ag showed stronger bactericidal capability toward not only normal Gram-negative/positive bacteria such as E. coli and S. aureus (similar to 100% of E. coli and similar to 95.3% of S. aureus reduction by 10 mu g/mL nanocomposite for 2.5 h), but also superbugs. Moreover, GO-PEG-Ag showed lower cytotoxicity toward HeLa cells. Importantly, GO-PEG-Ag presented long-term antibacterial effectiveness, remaining similar to 95% antibacterial activity after one-week storage in saline solution versus <35% for GO-Ag. The antibacterial mechanisms of GO-PEG-Ag were evidenced as damage to the bacterial structure and production of reactive oxygen species, causing cytoplasm leakage and metabolism decrease. The stable GO-PEG-Ag nanocomposite with powerful and long-term antibacterial capability provides a more practical and effective strategy for fighting superbugs-including pathogen threats in biomedicine and public health.
关键词Graphene Oxide Pegylation Silver Nanoparticles Antibacterial Activity Antibiotic Resistance Stability Long-term Effectiveness
DOI10.1021/acsami.7b03987
收录类别SCI
语种英语
WOS记录号WOS:000401307100013
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/27448
专题中科院上海应用物理研究所2011-2018年
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Zhao, RT,Lv, M,Li, Y,et al. Stable Nanocomposite Based on PEGylated and Silver Nanoparticles Loaded Graphene Oxide for Long-Term Antibacterial Activity[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(18):15328-15341.
APA Zhao, RT.,Lv, M.,Li, Y.,Sun, MX.,Kong, W.,...&Hao, RZ.(2017).Stable Nanocomposite Based on PEGylated and Silver Nanoparticles Loaded Graphene Oxide for Long-Term Antibacterial Activity.ACS APPLIED MATERIALS & INTERFACES,9(18),15328-15341.
MLA Zhao, RT,et al."Stable Nanocomposite Based on PEGylated and Silver Nanoparticles Loaded Graphene Oxide for Long-Term Antibacterial Activity".ACS APPLIED MATERIALS & INTERFACES 9.18(2017):15328-15341.
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