The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28)
Su, LL; Lu, C; Yan, P; Zhang, N; Cai, S; Zhang, GJ; Zhou, XF; Li, B
2017
发表期刊ACTA BIOCHIMICA ET BIOPHYSICA SINICA
ISSN1672-9145
卷号49期号:4页码:355-360
文章类型期刊论文
摘要Metal ions play a critical role in human islet amyloid polypeptide (hIAPP) aggregation, which is believed to be closely associated with beta-cell death in type II diabetes. In this work, the effect of Al3+ on the aggregation of hIAPP (11-28) was studied by several different experimental approaches. Atomic force microscopy measurements showed that Al3+ could remarkably inhibit hIAPP(11-28) fibrillogenesis, while Zn2+ had a slight promotion effect on peptide aggregation, which was also confirmed by Thioflavin T fluorescence observation. Furthermore, X-ray photoelectron spectroscopy measurement indicated that Al ions might form chemical bonds with neighboring atoms and destroy the secondary structures of the protein. Our studies could deepen the understanding of the role of metal ions in the aggregation of amyloid peptides.
关键词Metal Ion Hiapp Peptides Atomic Force Microscopy Thioflavin t Fluorescence X-ray Photoelectron Spectroscopy
DOI10.1093/abbs/gmx015
收录类别SCI
语种英语
WOS记录号WOS:000398771900008
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/27472
专题中科院上海应用物理研究所2011-2018年
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GB/T 7714
Su, LL,Lu, C,Yan, P,et al. The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28)[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2017,49(4):355-360.
APA Su, LL.,Lu, C.,Yan, P.,Zhang, N.,Cai, S.,...&Li, B.(2017).The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28).ACTA BIOCHIMICA ET BIOPHYSICA SINICA,49(4),355-360.
MLA Su, LL,et al."The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28)".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 49.4(2017):355-360.
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