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CAS OpenIR  > 中科院上海应用物理研究所2011-2017年  > 期刊论文
题名:
The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28)
作者: Su, LL; Lu, C; Yan, P; Zhang, N; Cai, S; Zhang, GJ; Zhou, XF; Li, B
刊名: ACTA BIOCHIMICA ET BIOPHYSICA SINICA
出版日期: 2017
卷号: 49, 期号:4, 页码:355-360
关键词: metal ion ; hIAPP peptides ; atomic force microscopy ; Thioflavin T fluorescence ; X-ray photoelectron spectroscopy
DOI: 10.1093/abbs/gmx015
文章类型: 期刊论文
英文摘要: Metal ions play a critical role in human islet amyloid polypeptide (hIAPP) aggregation, which is believed to be closely associated with beta-cell death in type II diabetes. In this work, the effect of Al3+ on the aggregation of hIAPP (11-28) was studied by several different experimental approaches. Atomic force microscopy measurements showed that Al3+ could remarkably inhibit hIAPP(11-28) fibrillogenesis, while Zn2+ had a slight promotion effect on peptide aggregation, which was also confirmed by Thioflavin T fluorescence observation. Furthermore, X-ray photoelectron spectroscopy measurement indicated that Al ions might form chemical bonds with neighboring atoms and destroy the secondary structures of the protein. Our studies could deepen the understanding of the role of metal ions in the aggregation of amyloid peptides.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000398771900008
ISSN号: 1672-9145
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/27472
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Su, LL,Lu, C,Yan, P,et al. The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28)[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2017-01-01,49(4):355-360.
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文件名: The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28).pdf
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