Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28) | |
| Su, LL; Lu, C; Yan, P; Zhang, N; Cai, S; Zhang, GJ; Zhou, XF; Li, B | |
| 2017 | |
| Source Publication | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| ISSN | 1672-9145 |
| Volume | 49Issue:4Pages:355-360 |
| Subtype | 期刊论文 |
| Abstract | Metal ions play a critical role in human islet amyloid polypeptide (hIAPP) aggregation, which is believed to be closely associated with beta-cell death in type II diabetes. In this work, the effect of Al3+ on the aggregation of hIAPP (11-28) was studied by several different experimental approaches. Atomic force microscopy measurements showed that Al3+ could remarkably inhibit hIAPP(11-28) fibrillogenesis, while Zn2+ had a slight promotion effect on peptide aggregation, which was also confirmed by Thioflavin T fluorescence observation. Furthermore, X-ray photoelectron spectroscopy measurement indicated that Al ions might form chemical bonds with neighboring atoms and destroy the secondary structures of the protein. Our studies could deepen the understanding of the role of metal ions in the aggregation of amyloid peptides. |
| Keyword | Metal Ion Hiapp Peptides Atomic Force Microscopy Thioflavin t Fluorescence X-ray Photoelectron Spectroscopy |
| DOI | 10.1093/abbs/gmx015 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000398771900008 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/27472 |
| Collection | 中科院上海应用物理研究所2011-2018年 |
| Recommended Citation GB/T 7714 | Su, LL,Lu, C,Yan, P,et al. The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28)[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2017,49(4):355-360. |
| APA | Su, LL.,Lu, C.,Yan, P.,Zhang, N.,Cai, S.,...&Li, B.(2017).The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28).ACTA BIOCHIMICA ET BIOPHYSICA SINICA,49(4),355-360. |
| MLA | Su, LL,et al."The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28)".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 49.4(2017):355-360. |
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| The effect of alumin（683KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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