Time-Resolved Spectroscopic Study of the Defluorination and Cyclization Reactions of Lomefloxacin in Water

doi:10.1021/acs.jpcb.6b11267

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	Time-Resolved Spectroscopic Study of the Defluorination and Cyclization Reactions of Lomefloxacin in Water
	Su, T; Li, MD; Ma, J; Phillips, DL
	2017
发表期刊	JOURNAL OF PHYSICAL CHEMISTRY B
ISSN	1520-6106
卷号	121 期号:17 页码:4512-4520
文章类型	期刊论文
摘要	The mechanism of the defluorination reaction(s) of lomefloxacin (LF) upon light illumination was investigated by using ultrafast laser flash photolysis combined with transient resonance Raman spectroscopy in near neutral water solution. The zwitterionic configuration of LF was determined to be the main species present in the near neutral water solution and was the species that was photoexcited to initiate the photochemical reaction. Femtosecond transient absorption revealed that the first excited singlet state (S-1) of LF did not appreciably undergo intersystem crossing (ISC), and instead partially decayed to the ground state via fluorescence emission, and there was partial cleavage of the carbon fluorine bond at position 8 to produce a singlet LF aryl cation intermediate. The transient resonance Raman results provided a direct observation and vibrational spectral characterization of the singlet LF aryl cation species. Subsequently, the transformation from the singlet LF aryl cation to a triplet carbene via an ISC process was seen in nanosecond transient absorption spectra. Finally, the triplet carbene experienced a cyclization reaction with the N-ethyl chain to form a tricyclic product.
DOI	10.1021/acs.jpcb.6b11267
收录类别	SCI
语种	英语
WOS记录号	WOS:000400881300020
引用统计
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/27487
专题	中科院上海应用物理研究所2011-2018年
推荐引用方式 GB/T 7714	Su, T,Li, MD,Ma, J,et al. Time-Resolved Spectroscopic Study of the Defluorination and Cyclization Reactions of Lomefloxacin in Water[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2017,121(17):4512-4520.
APA	Su, T,Li, MD,Ma, J,&Phillips, DL.(2017).Time-Resolved Spectroscopic Study of the Defluorination and Cyclization Reactions of Lomefloxacin in Water.JOURNAL OF PHYSICAL CHEMISTRY B,121(17),4512-4520.
MLA	Su, T,et al."Time-Resolved Spectroscopic Study of the Defluorination and Cyclization Reactions of Lomefloxacin in Water".JOURNAL OF PHYSICAL CHEMISTRY B 121.17(2017):4512-4520.

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