Application Progress of DNA Nanostructures in Drug Delivery and Smart Drug Carriers
Zhao, Y; Guo, LJ; Dai, JB; Li, Q; Li, D; Wang, LH
2017
发表期刊CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
ISSN0253-3820
卷号45期号:7页码:1078-1086
文章类型期刊论文
摘要The nanocarrier systems have been widely used for improving solubility, stability and therapeutic activity of drugs due to their high drug-loading efficiency, good target specificity and long circulation time. To achieve precisely controlled loading and tumor-selective release of drugs, extensive researches have been focused on developing nanocarriers with low toxicity, excellent biocomapatibility and biodegradability. As a type of nano-biomaterials with various functions and applications, self-assembled DNA nanostructures explored new ways to develop drug carriers in smart drug delivery based on their well-defined structures, good biocompatibility and stability, high cell membrane permeability and controlled drug releasing property. In this review, we summarized the developing course and the recent advances of DNA nanostructures for drug delivery, including the application of both static and dynamic DNA nanostructures. The application of dynamic DNA nanostructures for controllable drug release showed great potential in smart drug delivery.
关键词Gold Nanoparticles Intracellular Delivery Origami Structures Gene-regulation Cancer-therapy Cells Design Oligonucleotides Nanotechnology Stability
DOI10.1016/S1872-2040(17)61027-2
关键词[WOS]GOLD NANOPARTICLES ; INTRACELLULAR DELIVERY ; ORIGAMI STRUCTURES ; GENE-REGULATION ; CANCER-THERAPY ; CELLS ; DESIGN ; OLIGONUCLEOTIDES ; NANOTECHNOLOGY ; STABILITY
收录类别SCI
语种英语
WOS记录号WOS:000407707300006
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文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28557
专题中科院上海应用物理研究所2011-2018年
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Zhao, Y,Guo, LJ,Dai, JB,et al. Application Progress of DNA Nanostructures in Drug Delivery and Smart Drug Carriers[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2017,45(7):1078-1086.
APA Zhao, Y,Guo, LJ,Dai, JB,Li, Q,Li, D,&Wang, LH.(2017).Application Progress of DNA Nanostructures in Drug Delivery and Smart Drug Carriers.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,45(7),1078-1086.
MLA Zhao, Y,et al."Application Progress of DNA Nanostructures in Drug Delivery and Smart Drug Carriers".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 45.7(2017):1078-1086.
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