Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer
Ren, WZ; Iqbal, MZ; Zeng, LY; Chen, TX; Pan, YW; Zhao, JS; Yin, H; Zhang, LL; Zhang, JC; Li, AG; Wu, AG
2017
发表期刊NANOSCALE
ISSN2040-3364
卷号9期号:31页码:11195-11204
文章类型期刊论文
摘要TiO2 nanomaterials have been widely used for anticancer drug carriers and UV/980 nm NIR triggered cancer synergistic platforms. However, traditional pure TiO2 nanocarriers encounter some serious drawbacks, such as low drug loading ability, limited tissue penetration of UV light, and heating effect of 980 nm NIR on normal tissue, which obstruct their further application in cancer treatment. To overcome those challenges, novel mesoporous silica (mSiO(2)) coated black TiO2 core-shell nanocomposites are designed and constructed as doxorubicin carriers for 808 nm NIR triggered thermal imaging guided photothermal therapy combined chemotherapy of breast cancer. Properties of the nanocomposites such as micro-morphology, size, drug loading ability and release, targeting performance, and therapy efficiency in vitro and in vivo were evaluated. The results indicated the core-shell nanocomposites with dramatically increased loading ability were pH-responsive/NIR-accelerated doxorubicin release nanocarriers and showed synergistic breast cancer treatment in vitro and in vivo. This study verifies that the newly prepared mSiO(2) coated black TiO2 core-shell nanocarriers can overcome the limitations of traditional TiO2 nanocarriers and thus improve and broaden usage of TiO2 nanoparticles in nanomedicine.
关键词Titanium-dioxide Photodynamic Therapy Photothermal Therapy Drug-delivery Nanoparticles Cells Nanostructures Nanocarriers Water Platform
DOI10.1039/c7nr04039c
关键词[WOS]TITANIUM-DIOXIDE ; PHOTODYNAMIC THERAPY ; PHOTOTHERMAL THERAPY ; DRUG-DELIVERY ; NANOPARTICLES ; CELLS ; NANOSTRUCTURES ; NANOCARRIERS ; WATER ; PLATFORM
收录类别SCI
语种英语
WOS记录号WOS:000407336600025
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28565
专题中科院上海应用物理研究所2011-2018年
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Ren, WZ,Iqbal, MZ,Zeng, LY,et al. Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer[J]. NANOSCALE,2017,9(31):11195-11204.
APA Ren, WZ.,Iqbal, MZ.,Zeng, LY.,Chen, TX.,Pan, YW.,...&Wu, AG.(2017).Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer.NANOSCALE,9(31),11195-11204.
MLA Ren, WZ,et al."Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer".NANOSCALE 9.31(2017):11195-11204.
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