CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer
Ren, WZ; Iqbal, MZ; Zeng, LY; Chen, TX; Pan, YW; Zhao, JS; Yin, H; Zhang, LL; Zhang, JC; Li, AG; Wu, AG
2017
Source PublicationNANOSCALE
ISSN2040-3364
Volume9Issue:31Pages:11195-11204
Subtype期刊论文
AbstractTiO2 nanomaterials have been widely used for anticancer drug carriers and UV/980 nm NIR triggered cancer synergistic platforms. However, traditional pure TiO2 nanocarriers encounter some serious drawbacks, such as low drug loading ability, limited tissue penetration of UV light, and heating effect of 980 nm NIR on normal tissue, which obstruct their further application in cancer treatment. To overcome those challenges, novel mesoporous silica (mSiO(2)) coated black TiO2 core-shell nanocomposites are designed and constructed as doxorubicin carriers for 808 nm NIR triggered thermal imaging guided photothermal therapy combined chemotherapy of breast cancer. Properties of the nanocomposites such as micro-morphology, size, drug loading ability and release, targeting performance, and therapy efficiency in vitro and in vivo were evaluated. The results indicated the core-shell nanocomposites with dramatically increased loading ability were pH-responsive/NIR-accelerated doxorubicin release nanocarriers and showed synergistic breast cancer treatment in vitro and in vivo. This study verifies that the newly prepared mSiO(2) coated black TiO2 core-shell nanocarriers can overcome the limitations of traditional TiO2 nanocarriers and thus improve and broaden usage of TiO2 nanoparticles in nanomedicine.
KeywordTitanium-dioxide Photodynamic Therapy Photothermal Therapy Drug-delivery Nanoparticles Cells Nanostructures Nanocarriers Water Platform
DOI10.1039/c7nr04039c
WOS KeywordTITANIUM-DIOXIDE ; PHOTODYNAMIC THERAPY ; PHOTOTHERMAL THERAPY ; DRUG-DELIVERY ; NANOPARTICLES ; CELLS ; NANOSTRUCTURES ; NANOCARRIERS ; WATER ; PLATFORM
Indexed BySCI
Language英语
WOS IDWOS:000407336600025
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/28565
Collection中科院上海应用物理研究所2011-2018年
Recommended Citation
GB/T 7714
Ren, WZ,Iqbal, MZ,Zeng, LY,et al. Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer[J]. NANOSCALE,2017,9(31):11195-11204.
APA Ren, WZ.,Iqbal, MZ.,Zeng, LY.,Chen, TX.,Pan, YW.,...&Wu, AG.(2017).Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer.NANOSCALE,9(31),11195-11204.
MLA Ren, WZ,et al."Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer".NANOSCALE 9.31(2017):11195-11204.
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