Dual-mode electrochemical analysis of microRNA-21 using gold nanoparticle-decorated MoS2 nanosheet
Su, S; Cao, WF; Liu, W; Lu, ZW; Zhu, D; Chao, J; Weng, LX; Wang, LH; Fan, CH; Wang, LH
2017
发表期刊BIOSENSORS & BIOELECTRONICS
ISSN0956-5663
卷号94期号:-页码:552-559
文章类型期刊论文
摘要The detection of microRNA plays an important role in early cancer diagnosis. Herein, a dual-mode electronic biosensor was developed for microRNA-21 (miRNA-21) detection based on gold nanoparticle-decorated MoS2 nanosheet (AuNPs@MoS2). A classical DNA "sandwich" structure was employed to construct MoS2-based electrochemical sensor, including capture DNA, target miRNA-21 and DNA-modified nanoprobe. [Fe(CN)(6)](3-/4-) and [Ru(NH3)(6)](3+) were selected as electrochemical indicators to monitor the preparation process and evaluate the performance of MoS2-based electrochemical biosensor by electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV), respectively. Such MoS2-based biosensor exhibited excellent performance for miRNA-21 detection in the range from 10 fM to 1 nM with detection limit of 0.78 fM and 0.45 fM for DPV and EIS technique, respectively. Furthermore, the proposed MoS2-based biosensor displayed high selectivity and stability, which could be used to determine miRNA-21 in human serum samples with satisfactory results. All data suggested that such MoS2-based nanocomposite may be a potential candidate for biosensing ranging from nucleic acid to protein detection.
关键词Graphene Oxide Signal Amplification Mos2/graphene Composites Breast-cancer Dna Nanostructure Biosensor Sensor Cells Strategy
DOI10.1016/j.bios.2017.03.040
关键词[WOS]GRAPHENE OXIDE ; SIGNAL AMPLIFICATION ; MOS2/GRAPHENE COMPOSITES ; BREAST-CANCER ; DNA ; NANOSTRUCTURE ; BIOSENSOR ; SENSOR ; CELLS ; STRATEGY
收录类别SCI
语种英语
WOS记录号WOS:000401201300073
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28619
专题中科院上海应用物理研究所2011-2018年
推荐引用方式
GB/T 7714
Su, S,Cao, WF,Liu, W,et al. Dual-mode electrochemical analysis of microRNA-21 using gold nanoparticle-decorated MoS2 nanosheet[J]. BIOSENSORS & BIOELECTRONICS,2017,94(-):552-559.
APA Su, S.,Cao, WF.,Liu, W.,Lu, ZW.,Zhu, D.,...&Wang, LH.(2017).Dual-mode electrochemical analysis of microRNA-21 using gold nanoparticle-decorated MoS2 nanosheet.BIOSENSORS & BIOELECTRONICS,94(-),552-559.
MLA Su, S,et al."Dual-mode electrochemical analysis of microRNA-21 using gold nanoparticle-decorated MoS2 nanosheet".BIOSENSORS & BIOELECTRONICS 94.-(2017):552-559.
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