Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation
Li, J; Green, AA; Yan, H; Fan, CH
2017
发表期刊NATURE CHEMISTRY
ISSN1755-4330
卷号9期号:11页码:1056-1067
文章类型期刊论文
摘要Nucleic acids have attracted widespread attention due to the simplicity with which they can be designed to form discrete structures and programmed to perform specific functions at the nanoscale. The advantages of DNA/RNA nanotechnology offer numerous opportunities for in-cell and in-vivo applications, and the technology holds great promise to advance the growing field of synthetic biology. Many elegant examples have revealed the potential in integrating nucleic acid nanostructures in cells and in vivo where they can perform important physiological functions. In this Review, we summarize the current abilities of DNA/RNA nanotechnology to realize applications in live cells and then discuss the key problems that must be solved to fully exploit the useful properties of nanostructures. Finally, we provide viewpoints on how to integrate the tools provided by DNA/RNA nanotechnology and related new technologies to construct nucleic acid nanostructure-based molecular circuitry for synthetic biology.
关键词Tetrahedral Dna Nanostructure Strand Displacement Cascades Hybridization Chain-reaction Green Fluorescent Protein Synthetic Biology Gene-expression Drug-delivery Logic Gates Mammalian-cells Living Cells
DOI10.1038/nchem.2852
关键词[WOS]TETRAHEDRAL DNA NANOSTRUCTURE ; STRAND DISPLACEMENT CASCADES ; HYBRIDIZATION CHAIN-REACTION ; GREEN FLUORESCENT PROTEIN ; SYNTHETIC BIOLOGY ; GENE-EXPRESSION ; DRUG-DELIVERY ; LOGIC GATES ; MAMMALIAN-CELLS ; LIVING CELLS
收录类别SCI
语种英语
WOS记录号WOS:000413569500006
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文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28641
专题中科院上海应用物理研究所2011-2018年
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Li, J,Green, AA,Yan, H,et al. Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation[J]. NATURE CHEMISTRY,2017,9(11):1056-1067.
APA Li, J,Green, AA,Yan, H,&Fan, CH.(2017).Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation.NATURE CHEMISTRY,9(11),1056-1067.
MLA Li, J,et al."Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation".NATURE CHEMISTRY 9.11(2017):1056-1067.
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