CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation
Li, J; Green, AA; Yan, H; Fan, CH
2017
Source PublicationNATURE CHEMISTRY
ISSN1755-4330
Volume9Issue:11Pages:1056-1067
Subtype期刊论文
AbstractNucleic acids have attracted widespread attention due to the simplicity with which they can be designed to form discrete structures and programmed to perform specific functions at the nanoscale. The advantages of DNA/RNA nanotechnology offer numerous opportunities for in-cell and in-vivo applications, and the technology holds great promise to advance the growing field of synthetic biology. Many elegant examples have revealed the potential in integrating nucleic acid nanostructures in cells and in vivo where they can perform important physiological functions. In this Review, we summarize the current abilities of DNA/RNA nanotechnology to realize applications in live cells and then discuss the key problems that must be solved to fully exploit the useful properties of nanostructures. Finally, we provide viewpoints on how to integrate the tools provided by DNA/RNA nanotechnology and related new technologies to construct nucleic acid nanostructure-based molecular circuitry for synthetic biology.
KeywordTetrahedral Dna Nanostructure Strand Displacement Cascades Hybridization Chain-reaction Green Fluorescent Protein Synthetic Biology Gene-expression Drug-delivery Logic Gates Mammalian-cells Living Cells
DOI10.1038/nchem.2852
WOS KeywordTETRAHEDRAL DNA NANOSTRUCTURE ; STRAND DISPLACEMENT CASCADES ; HYBRIDIZATION CHAIN-REACTION ; GREEN FLUORESCENT PROTEIN ; SYNTHETIC BIOLOGY ; GENE-EXPRESSION ; DRUG-DELIVERY ; LOGIC GATES ; MAMMALIAN-CELLS ; LIVING CELLS
Indexed BySCI
Language英语
WOS IDWOS:000413569500006
Citation statistics
Cited Times:45[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/28641
Collection中科院上海应用物理研究所2011-2018年
Recommended Citation
GB/T 7714
Li, J,Green, AA,Yan, H,et al. Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation[J]. NATURE CHEMISTRY,2017,9(11):1056-1067.
APA Li, J,Green, AA,Yan, H,&Fan, CH.(2017).Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation.NATURE CHEMISTRY,9(11),1056-1067.
MLA Li, J,et al."Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation".NATURE CHEMISTRY 9.11(2017):1056-1067.
Files in This Item: Download All
File Name/Size DocType Version Access License
Engineering nucleic (9981KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, J]'s Articles
[Green, AA]'s Articles
[Yan, H]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, J]'s Articles
[Green, AA]'s Articles
[Yan, H]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, J]'s Articles
[Green, AA]'s Articles
[Yan, H]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.