CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase
Tian, J; Yan, QL; Zhu, Y; Zhang, JC; Li, J; Shi, B; Xu, G; Fan, CH; Zhao, CC
2017
Source PublicationCHINESE JOURNAL OF CHEMISTRY
ISSN1001-604X
Volume35Issue:11Pages:1711-1716
Subtype期刊论文
AbstractA fluorescent turn-on probe for specifically targeting gamma-glutamyltranspeptidase (GGT) was designed and synthesized by integrating boron-dipyrromethene (BODIPY) as a chromophore and glutathione (GSH) as the GGT substrate. GGT-catalyzed the cleavage of the gamma-glutamyl bond and generated the aromatic hydrocarbon transfer between the sulfur and the nitrogen atom in BODIPY, leading to distinct optical changes. Such specific responsiveness provides an easily distinguishable fluorescence signal to visualize the GGT activity in living cells and differentiate GGT-positive cancer cells from GGT-negative cells.
KeywordLiving Cells Selective Detection Fluoride-ion Transferase Homocysteine Glutathione Expression Cysteine Design Sensor
DOI10.1002/cjoc.201700248
Indexed BySCI
WOS KeywordLIVING CELLS ; SELECTIVE DETECTION ; FLUORIDE-ION ; TRANSFERASE ; HOMOCYSTEINE ; GLUTATHIONE ; EXPRESSION ; CYSTEINE ; DESIGN ; SENSOR
Language英语
WOS IDWOS:000417173600010
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/28644
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Tian, J,Yan, QL,Zhu, Y,et al. Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase[J]. CHINESE JOURNAL OF CHEMISTRY,2017,35(11):1711-1716.
APA Tian, J.,Yan, QL.,Zhu, Y.,Zhang, JC.,Li, J.,...&Zhao, CC.(2017).Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase.CHINESE JOURNAL OF CHEMISTRY,35(11),1711-1716.
MLA Tian, J,et al."Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase".CHINESE JOURNAL OF CHEMISTRY 35.11(2017):1711-1716.
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