Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase

doi:10.1002/cjoc.201700248

CAS OpenIR > 中科院上海应用物理研究所2011-2019年

	Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase
	Tian, J; Yan, QL; Zhu, Y; Zhang, JC; Li, J; Shi, B; Xu, G; Fan, CH; Zhao, CC
	2017
Source Publication	CHINESE JOURNAL OF CHEMISTRY
ISSN	1001-604X
Volume	35 Issue:11 Pages:1711-1716
Subtype	期刊论文
Abstract	A fluorescent turn-on probe for specifically targeting gamma-glutamyltranspeptidase (GGT) was designed and synthesized by integrating boron-dipyrromethene (BODIPY) as a chromophore and glutathione (GSH) as the GGT substrate. GGT-catalyzed the cleavage of the gamma-glutamyl bond and generated the aromatic hydrocarbon transfer between the sulfur and the nitrogen atom in BODIPY, leading to distinct optical changes. Such specific responsiveness provides an easily distinguishable fluorescence signal to visualize the GGT activity in living cells and differentiate GGT-positive cancer cells from GGT-negative cells.
Keyword	Living Cells Selective Detection Fluoride-ion Transferase Homocysteine Glutathione Expression Cysteine Design Sensor
DOI	10.1002/cjoc.201700248
Indexed By	SCI
WOS Keyword	LIVING CELLS ; SELECTIVE DETECTION ; FLUORIDE-ION ; TRANSFERASE ; HOMOCYSTEINE ; GLUTATHIONE ; EXPRESSION ; CYSTEINE ; DESIGN ; SENSOR
Language	英语
WOS ID	WOS:000417173600010
Citation statistics	Cited Times:7[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/28644
Collection	中科院上海应用物理研究所2011-2019年
Recommended Citation GB/T 7714	Tian, J,Yan, QL,Zhu, Y,et al. Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase[J]. CHINESE JOURNAL OF CHEMISTRY,2017,35(11):1711-1716.
APA	Tian, J.,Yan, QL.,Zhu, Y.,Zhang, JC.,Li, J.,...&Zhao, CC.(2017).Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase.CHINESE JOURNAL OF CHEMISTRY,35(11),1711-1716.
MLA	Tian, J,et al."Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase".CHINESE JOURNAL OF CHEMISTRY 35.11(2017):1711-1716.

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