Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase

doi:10.1002/cjoc.201700248

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase
	Tian, J; Yan, QL; Zhu, Y; Zhang, JC; Li, J; Shi, B; Xu, G; Fan, CH; Zhao, CC
	2017
发表期刊	CHINESE JOURNAL OF CHEMISTRY
ISSN	1001-604X
卷号	35 期号:11 页码:1711-1716
文章类型	期刊论文
摘要	A fluorescent turn-on probe for specifically targeting gamma-glutamyltranspeptidase (GGT) was designed and synthesized by integrating boron-dipyrromethene (BODIPY) as a chromophore and glutathione (GSH) as the GGT substrate. GGT-catalyzed the cleavage of the gamma-glutamyl bond and generated the aromatic hydrocarbon transfer between the sulfur and the nitrogen atom in BODIPY, leading to distinct optical changes. Such specific responsiveness provides an easily distinguishable fluorescence signal to visualize the GGT activity in living cells and differentiate GGT-positive cancer cells from GGT-negative cells.
关键词	Living Cells Selective Detection Fluoride-ion Transferase Homocysteine Glutathione Expression Cysteine Design Sensor
DOI	10.1002/cjoc.201700248
关键词[WOS]	LIVING CELLS ; SELECTIVE DETECTION ; FLUORIDE-ION ; TRANSFERASE ; HOMOCYSTEINE ; GLUTATHIONE ; EXPRESSION ; CYSTEINE ; DESIGN ; SENSOR
收录类别	SCI
语种	英语
WOS记录号	WOS:000417173600010
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/28644
专题	中科院上海应用物理研究所2011-2018年
推荐引用方式 GB/T 7714	Tian, J,Yan, QL,Zhu, Y,et al. Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase[J]. CHINESE JOURNAL OF CHEMISTRY,2017,35(11):1711-1716.
APA	Tian, J.,Yan, QL.,Zhu, Y.,Zhang, JC.,Li, J.,...&Zhao, CC.(2017).Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase.CHINESE JOURNAL OF CHEMISTRY,35(11),1711-1716.
MLA	Tian, J,et al."Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase".CHINESE JOURNAL OF CHEMISTRY 35.11(2017):1711-1716.

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Enzyme-Triggered Flu（1607KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	请求全文