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| Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase | |
| Tian, J; Yan, QL; Zhu, Y; Zhang, JC; Li, J; Shi, B; Xu, G; Fan, CH; Zhao, CC | |
| 2017 | |
| Source Publication | CHINESE JOURNAL OF CHEMISTRY
 |
| ISSN | 1001-604X |
| Volume | 35Issue:11Pages:1711-1716 |
| Subtype | 期刊论文 |
| Abstract | A fluorescent turn-on probe for specifically targeting gamma-glutamyltranspeptidase (GGT) was designed and synthesized by integrating boron-dipyrromethene (BODIPY) as a chromophore and glutathione (GSH) as the GGT substrate. GGT-catalyzed the cleavage of the gamma-glutamyl bond and generated the aromatic hydrocarbon transfer between the sulfur and the nitrogen atom in BODIPY, leading to distinct optical changes. Such specific responsiveness provides an easily distinguishable fluorescence signal to visualize the GGT activity in living cells and differentiate GGT-positive cancer cells from GGT-negative cells. |
| Keyword | Living Cells Selective Detection Fluoride-ion Transferase Homocysteine Glutathione Expression Cysteine Design Sensor |
| DOI | 10.1002/cjoc.201700248 |
| Indexed By | SCI |
| WOS Keyword | LIVING CELLS ; SELECTIVE DETECTION ; FLUORIDE-ION ; TRANSFERASE ; HOMOCYSTEINE ; GLUTATHIONE ; EXPRESSION ; CYSTEINE ; DESIGN ; SENSOR |
| Language | 英语 |
| WOS ID | WOS:000417173600010 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/28644 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Recommended Citation GB/T 7714 | Tian, J,Yan, QL,Zhu, Y,et al. Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase[J]. CHINESE JOURNAL OF CHEMISTRY,2017,35(11):1711-1716. |
| APA | Tian, J.,Yan, QL.,Zhu, Y.,Zhang, JC.,Li, J.,...&Zhao, CC.(2017).Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase.CHINESE JOURNAL OF CHEMISTRY,35(11),1711-1716. |
| MLA | Tian, J,et al."Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase".CHINESE JOURNAL OF CHEMISTRY 35.11(2017):1711-1716. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Enzyme-Triggered Flu（1607KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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