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Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat
Hou, Y; Xia, Y; Pan, YK; Tang, SC; Sun, XF; Xie, Y; Guo, H; Wei, J
2017
Source PublicationMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN0928-4931
Volume76Issue:-Pages:340-349
Subtype期刊论文
AbstractEfficacious hemostatic agents have significant potential application in visceral organ or large vessel arterial injure. In this study, mesoporous zinc-calcium silicate (m-ZCS) was synthesized, and microporous starch (MS) based hemostatic agents of m-ZCS/MS composites for hemorrhage control was fabricated. The results showed that the incorporation of m-ZCS into MS significantly enhanced the water absorption and degradability of the composites, which were dependent on the m-ZCS content Moreover, the composites with antibacterial property could inhibit the growth of Escherichia coli (E. coli) and the antibacterial ratios increased with the m-ZCS content. The in vitro coagulation evaluation by using activated partial thromboplastin time (APTT) and prothrombin time (PT) revealed that the composites significantly activated the intrinsic and extrinsic pathway of coagulation cascade. In addition, for the animal model of rabbits in ear vein, skin, arterial and liver injuries, the hemostatic time of the composites obviously reduced with the increase of m-ZSC content, in which the composite with 15 wt% m-ZCS content (15mZSC) showed remarkable efficacy on bleeding control. The composites could promote the viability of L929 cells,.indicating no cytotoxicity of the composites. The results suggested that the m-ZCS/MS composites with excellent hemostatic and antibacterial properties might be a candidate for controlling bleeding and infection. 2017 Published by Elsevier B.V.
KeywordLethal Groin Injury Hemorrhage Control Agents Chitosan Battlefield Infection Dressings Sponge Model
DOI10.1016/j.msec.2017.03.094
WOS KeywordLETHAL GROIN INJURY ; HEMORRHAGE CONTROL ; AGENTS ; CHITOSAN ; BATTLEFIELD ; INFECTION ; DRESSINGS ; SPONGE ; MODEL
Indexed BySCI
Language英语
WOS IDWOS:000405541600041
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Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/28701
Collection中科院上海应用物理研究所2011-2018年
Recommended Citation
GB/T 7714
Hou, Y,Xia, Y,Pan, YK,et al. Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017,76(-):340-349.
APA Hou, Y.,Xia, Y.,Pan, YK.,Tang, SC.,Sun, XF.,...&Wei, J.(2017).Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,76(-),340-349.
MLA Hou, Y,et al."Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 76.-(2017):340-349.
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