Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat
Hou, Y; Xia, Y; Pan, YK; Tang, SC; Sun, XF; Xie, Y; Guo, H; Wei, J
2017
发表期刊MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN0928-4931
卷号76期号:-页码:340-349
文章类型期刊论文
摘要Efficacious hemostatic agents have significant potential application in visceral organ or large vessel arterial injure. In this study, mesoporous zinc-calcium silicate (m-ZCS) was synthesized, and microporous starch (MS) based hemostatic agents of m-ZCS/MS composites for hemorrhage control was fabricated. The results showed that the incorporation of m-ZCS into MS significantly enhanced the water absorption and degradability of the composites, which were dependent on the m-ZCS content Moreover, the composites with antibacterial property could inhibit the growth of Escherichia coli (E. coli) and the antibacterial ratios increased with the m-ZCS content. The in vitro coagulation evaluation by using activated partial thromboplastin time (APTT) and prothrombin time (PT) revealed that the composites significantly activated the intrinsic and extrinsic pathway of coagulation cascade. In addition, for the animal model of rabbits in ear vein, skin, arterial and liver injuries, the hemostatic time of the composites obviously reduced with the increase of m-ZSC content, in which the composite with 15 wt% m-ZCS content (15mZSC) showed remarkable efficacy on bleeding control. The composites could promote the viability of L929 cells,.indicating no cytotoxicity of the composites. The results suggested that the m-ZCS/MS composites with excellent hemostatic and antibacterial properties might be a candidate for controlling bleeding and infection. 2017 Published by Elsevier B.V.
关键词Lethal Groin Injury Hemorrhage Control Agents Chitosan Battlefield Infection Dressings Sponge Model
DOI10.1016/j.msec.2017.03.094
关键词[WOS]LETHAL GROIN INJURY ; HEMORRHAGE CONTROL ; AGENTS ; CHITOSAN ; BATTLEFIELD ; INFECTION ; DRESSINGS ; SPONGE ; MODEL
收录类别SCI
语种英语
WOS记录号WOS:000405541600041
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28701
专题中科院上海应用物理研究所2011-2018年
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Hou, Y,Xia, Y,Pan, YK,et al. Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017,76(-):340-349.
APA Hou, Y.,Xia, Y.,Pan, YK.,Tang, SC.,Sun, XF.,...&Wei, J.(2017).Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,76(-),340-349.
MLA Hou, Y,et al."Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 76.-(2017):340-349.
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