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| Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy | |
| Chen, WQ; Peng, Y; Jiang, XK; Zhao, JY; Zhao, HW; Zhu, YM | |
| 2017 | |
| Source Publication | SCIENTIFIC REPORTS
 |
| ISSN | 2045-2322 |
| Volume | 7Issue:-Pages:- |
| Subtype | 期刊论文 |
| Abstract | 2-Hydroxyglutaric acid disodium salt (2HG) is a unique biomarker existing in glioma, which can be used for recognizing cancer development stage and identifying the boundary between the ordinary tissue and cancer tissue. However, the most efficient detection method for 2HG now is Magnetic Resonance Spectroscopy (MRS), whose testing time is at least twenty minutes and the variability of 2HG (continuous synthesis and decomposition) determines it cannot be used as the real-time image in medical surgery. In this paper, by using the Terahertz Time-domain Spectroscopy (THz-TDS) System, we investigate the vibration spectra of 2HG isomers and further distinguish their physical properties by using Density Functional Theory. The differences between isomers are mainly attributed to the proton transfer inside the carbon chain. These results indicate that terahertz technology can identify the isomers of 2HG accurate and fast, which has important significance for the further investigation of glioma and clinical surgery. |
| Keyword | Magnetic-resonance-spectroscopy Density-functional Theory Gliomas (r)-2-hydroxyglutarate Radiation Cancer Idh1 |
| DOI | 10.1038/s41598-017-11527-z |
| WOS Keyword | MAGNETIC-RESONANCE-SPECTROSCOPY ; DENSITY-FUNCTIONAL THEORY ; GLIOMAS ; (R)-2-HYDROXYGLUTARATE ; RADIATION ; CANCER ; IDH1 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000411434900032 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/28714 |
| Collection | 中科院上海应用物理研究所2011-2018年 |
| Recommended Citation GB/T 7714 | Chen, WQ,Peng, Y,Jiang, XK,et al. Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy[J]. SCIENTIFIC REPORTS,2017,7(-):-. |
| APA | Chen, WQ,Peng, Y,Jiang, XK,Zhao, JY,Zhao, HW,&Zhu, YM.(2017).Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy.SCIENTIFIC REPORTS,7(-),-. |
| MLA | Chen, WQ,et al."Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy".SCIENTIFIC REPORTS 7.-(2017):-. |
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| File Name/Size | DocType | Version | Access | License | ||
| Isomers Identificati（1562KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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