Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy

doi:10.1038/s41598-017-11527-z

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	Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy
	Chen, WQ; Peng, Y; Jiang, XK; Zhao, JY; Zhao, HW; Zhu, YM
	2017
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	7 期号:-页码:-
文章类型	期刊论文
摘要	2-Hydroxyglutaric acid disodium salt (2HG) is a unique biomarker existing in glioma, which can be used for recognizing cancer development stage and identifying the boundary between the ordinary tissue and cancer tissue. However, the most efficient detection method for 2HG now is Magnetic Resonance Spectroscopy (MRS), whose testing time is at least twenty minutes and the variability of 2HG (continuous synthesis and decomposition) determines it cannot be used as the real-time image in medical surgery. In this paper, by using the Terahertz Time-domain Spectroscopy (THz-TDS) System, we investigate the vibration spectra of 2HG isomers and further distinguish their physical properties by using Density Functional Theory. The differences between isomers are mainly attributed to the proton transfer inside the carbon chain. These results indicate that terahertz technology can identify the isomers of 2HG accurate and fast, which has important significance for the further investigation of glioma and clinical surgery.
关键词	Magnetic-resonance-spectroscopy Density-functional Theory Gliomas (r)-2-hydroxyglutarate Radiation Cancer Idh1
DOI	10.1038/s41598-017-11527-z
关键词[WOS]	MAGNETIC-RESONANCE-SPECTROSCOPY ; DENSITY-FUNCTIONAL THEORY ; GLIOMAS ; (R)-2-HYDROXYGLUTARATE ; RADIATION ; CANCER ; IDH1
收录类别	SCI
语种	英语
WOS记录号	WOS:000411434900032
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/28714
专题	中科院上海应用物理研究所2011-2018年
推荐引用方式 GB/T 7714	Chen, WQ,Peng, Y,Jiang, XK,et al. Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy[J]. SCIENTIFIC REPORTS,2017,7(-):-.
APA	Chen, WQ,Peng, Y,Jiang, XK,Zhao, JY,Zhao, HW,&Zhu, YM.(2017).Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy.SCIENTIFIC REPORTS,7(-),-.
MLA	Chen, WQ,et al."Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy".SCIENTIFIC REPORTS 7.-(2017):-.

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