CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy
Chen, WQ; Peng, Y; Jiang, XK; Zhao, JY; Zhao, HW; Zhu, YM
2017
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume7Issue:-Pages:-
Subtype期刊论文
Abstract2-Hydroxyglutaric acid disodium salt (2HG) is a unique biomarker existing in glioma, which can be used for recognizing cancer development stage and identifying the boundary between the ordinary tissue and cancer tissue. However, the most efficient detection method for 2HG now is Magnetic Resonance Spectroscopy (MRS), whose testing time is at least twenty minutes and the variability of 2HG (continuous synthesis and decomposition) determines it cannot be used as the real-time image in medical surgery. In this paper, by using the Terahertz Time-domain Spectroscopy (THz-TDS) System, we investigate the vibration spectra of 2HG isomers and further distinguish their physical properties by using Density Functional Theory. The differences between isomers are mainly attributed to the proton transfer inside the carbon chain. These results indicate that terahertz technology can identify the isomers of 2HG accurate and fast, which has important significance for the further investigation of glioma and clinical surgery.
KeywordMagnetic-resonance-spectroscopy Density-functional Theory Gliomas (r)-2-hydroxyglutarate Radiation Cancer Idh1
DOI10.1038/s41598-017-11527-z
Indexed BySCI
WOS KeywordMAGNETIC-RESONANCE-SPECTROSCOPY ; DENSITY-FUNCTIONAL THEORY ; GLIOMAS ; (R)-2-HYDROXYGLUTARATE ; RADIATION ; CANCER ; IDH1
Language英语
WOS IDWOS:000411434900032
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/28714
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Chen, WQ,Peng, Y,Jiang, XK,et al. Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy[J]. SCIENTIFIC REPORTS,2017,7(-):-.
APA Chen, WQ,Peng, Y,Jiang, XK,Zhao, JY,Zhao, HW,&Zhu, YM.(2017).Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy.SCIENTIFIC REPORTS,7(-),-.
MLA Chen, WQ,et al."Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy".SCIENTIFIC REPORTS 7.-(2017):-.
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