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| Multifunctional Yolk-Shell Nanostructure as a Superquencher for Fluorescent Analysis of Potassium Ion Using Guanine-Rich Oligonucleotides | |
| Lu, N; Wen, YL; Liu, G; Ding, L; Zeng, CX; Aldalbahi, A; Khan, MN; Periyasami, G; Rahaman, M; Alrohaili, A; Shi, JY; Song, SP; Wang, LH; Zhang, M | |
| 2017 | |
| Source Publication | ACS APPLIED MATERIALS & INTERFACES
 |
| ISSN | 1944-8244 |
| Volume | 9Issue:36Pages:30406-30413 |
| Subtype | 期刊论文 |
| Abstract | The excellent performance of a biosensor generally depends on the high signal-to-noise ratio, and the superquencher plays a dominant role in fluorescent sensors. Novel nanoquenchers exhibited high quenching efficiency in various fluorescent assays of biological/chemical molecules. Here, we developed a novel nano-biosensor using Fe3O4@C yolk-shell nanoparticles (YSNPs) and studied their quenching effect. We found Fe3O4@C YSNP was a superquencher and exhibited an ultrastrong quenching ability, up to almost 100% quenching efficiency, toward fluorophores. Also, Fe3O4@C YSNPs possessed the most superior fluorescence restoration efficiency, due to biomolecular recognition event, compared to the other nanoquenchers, including bare Fe3O4 NPs, graphene oxide (GO), and single-wall carbon nanotubes (SWCNTs). On the basis of that, a fluorescent sensing platform for potassium-ion (K+) analysis with guanine (G)-rich oligonucleotides was designed. As a result, Fe3O4@C YSNP-based fluorescent sensors demonstrated excellent performance, with an ultrahigh sensitivity of a detection limit as low as 1.3 mu M, as well as a wide dynamic range from 50 mu M to 10 mM. The proposed method is fast, simple, and cost-effective, suggesting the great potential for practical applications in biomedical detection and clinical diagnosis. |
| Keyword | Unmodified Gold Nanoparticles In-vivo Colorimetric Detection Drug-delivery Magnetic Nanoparticles Carbon Nanotubes Graphene Oxide Porous Shells Quantum Dots Label-free |
| DOI | 10.1021/acsami.7b08732 |
| Indexed By | SCI |
| WOS Keyword | UNMODIFIED GOLD NANOPARTICLES ; IN-VIVO ; COLORIMETRIC DETECTION ; DRUG-DELIVERY ; MAGNETIC NANOPARTICLES ; CARBON NANOTUBES ; GRAPHENE OXIDE ; POROUS SHELLS ; QUANTUM DOTS ; LABEL-FREE |
| Language | 英语 |
| WOS ID | WOS:000411043600019 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/28742 |
| Collection | 中科院上海应用物理研究所2011-2019年 |
| Recommended Citation GB/T 7714 | Lu, N,Wen, YL,Liu, G,et al. Multifunctional Yolk-Shell Nanostructure as a Superquencher for Fluorescent Analysis of Potassium Ion Using Guanine-Rich Oligonucleotides[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(36):30406-30413. |
| APA | Lu, N.,Wen, YL.,Liu, G.,Ding, L.,Zeng, CX.,...&Zhang, M.(2017).Multifunctional Yolk-Shell Nanostructure as a Superquencher for Fluorescent Analysis of Potassium Ion Using Guanine-Rich Oligonucleotides.ACS APPLIED MATERIALS & INTERFACES,9(36),30406-30413. |
| MLA | Lu, N,et al."Multifunctional Yolk-Shell Nanostructure as a Superquencher for Fluorescent Analysis of Potassium Ion Using Guanine-Rich Oligonucleotides".ACS APPLIED MATERIALS & INTERFACES 9.36(2017):30406-30413. |
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| Multifunctional Yolk（2318KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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