Multifunctional Yolk-Shell Nanostructure as a Superquencher for Fluorescent Analysis of Potassium Ion Using Guanine-Rich Oligonucleotides
Lu, N; Wen, YL; Liu, G; Ding, L; Zeng, CX; Aldalbahi, A; Khan, MN; Periyasami, G; Rahaman, M; Alrohaili, A; Shi, JY; Song, SP; Wang, LH; Zhang, M
2017
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号9期号:36页码:30406-30413
文章类型期刊论文
摘要The excellent performance of a biosensor generally depends on the high signal-to-noise ratio, and the superquencher plays a dominant role in fluorescent sensors. Novel nanoquenchers exhibited high quenching efficiency in various fluorescent assays of biological/chemical molecules. Here, we developed a novel nano-biosensor using Fe3O4@C yolk-shell nanoparticles (YSNPs) and studied their quenching effect. We found Fe3O4@C YSNP was a superquencher and exhibited an ultrastrong quenching ability, up to almost 100% quenching efficiency, toward fluorophores. Also, Fe3O4@C YSNPs possessed the most superior fluorescence restoration efficiency, due to biomolecular recognition event, compared to the other nanoquenchers, including bare Fe3O4 NPs, graphene oxide (GO), and single-wall carbon nanotubes (SWCNTs). On the basis of that, a fluorescent sensing platform for potassium-ion (K+) analysis with guanine (G)-rich oligonucleotides was designed. As a result, Fe3O4@C YSNP-based fluorescent sensors demonstrated excellent performance, with an ultrahigh sensitivity of a detection limit as low as 1.3 mu M, as well as a wide dynamic range from 50 mu M to 10 mM. The proposed method is fast, simple, and cost-effective, suggesting the great potential for practical applications in biomedical detection and clinical diagnosis.
关键词Unmodified Gold Nanoparticles In-vivo Colorimetric Detection Drug-delivery Magnetic Nanoparticles Carbon Nanotubes Graphene Oxide Porous Shells Quantum Dots Label-free
DOI10.1021/acsami.7b08732
关键词[WOS]UNMODIFIED GOLD NANOPARTICLES ; IN-VIVO ; COLORIMETRIC DETECTION ; DRUG-DELIVERY ; MAGNETIC NANOPARTICLES ; CARBON NANOTUBES ; GRAPHENE OXIDE ; POROUS SHELLS ; QUANTUM DOTS ; LABEL-FREE
收录类别SCI
语种英语
WOS记录号WOS:000411043600019
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28742
专题中科院上海应用物理研究所2011-2018年
推荐引用方式
GB/T 7714
Lu, N,Wen, YL,Liu, G,et al. Multifunctional Yolk-Shell Nanostructure as a Superquencher for Fluorescent Analysis of Potassium Ion Using Guanine-Rich Oligonucleotides[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(36):30406-30413.
APA Lu, N.,Wen, YL.,Liu, G.,Ding, L.,Zeng, CX.,...&Zhang, M.(2017).Multifunctional Yolk-Shell Nanostructure as a Superquencher for Fluorescent Analysis of Potassium Ion Using Guanine-Rich Oligonucleotides.ACS APPLIED MATERIALS & INTERFACES,9(36),30406-30413.
MLA Lu, N,et al."Multifunctional Yolk-Shell Nanostructure as a Superquencher for Fluorescent Analysis of Potassium Ion Using Guanine-Rich Oligonucleotides".ACS APPLIED MATERIALS & INTERFACES 9.36(2017):30406-30413.
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