Preservation of DNA Nanostructure Carriers: Effects of Freeze - Thawing and Ionic Strength during Lyophilization and Storage
Zhu, B; Zhao, Y; Dai, JB; Wang, JB; Xing, S; Guo, LJ; Chen, N; Qu, XM; Li, L; Shen, JW; Shi, JY; Li, J; Wang, LH
2017
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号9期号:22页码:18434-18439
文章类型期刊论文
摘要DNA rianostiuctures have: attracted wide interest-in biomedical applications, especially as nanocarriers for drug delivery. Therefore, it is.important to ensure:the structural integrity of DNA nanostructures under ambient temperature storage. In this study, we examined lyophilization-based preservation of DNA nanostructures by investigating the structural integrity of different DNA nanostructures reconstituted from lyophilization. We demonstrated that lyophilization Under appropriate ionic strength is amenable to the storage of DNA. nanostructures Compared with that stored in liquid solutiOn, DNA nanostructure carriers reconstituted from lyophilization showed significantly better structural integrity after an accelerated aging test equivalent to 100-day room-temperature storage.
关键词Delivery Stability Origami Nanoparticles Complexes
DOI10.1021/acsami.7b04784
关键词[WOS]DELIVERY ; STABILITY ; ORIGAMI ; NANOPARTICLES ; COMPLEXES
收录类别SCI
语种英语
WOS记录号WOS:000403136400007
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28780
专题中科院上海应用物理研究所2011-2018年
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GB/T 7714
Zhu, B,Zhao, Y,Dai, JB,et al. Preservation of DNA Nanostructure Carriers: Effects of Freeze - Thawing and Ionic Strength during Lyophilization and Storage[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(22):18434-18439.
APA Zhu, B.,Zhao, Y.,Dai, JB.,Wang, JB.,Xing, S.,...&Wang, LH.(2017).Preservation of DNA Nanostructure Carriers: Effects of Freeze - Thawing and Ionic Strength during Lyophilization and Storage.ACS APPLIED MATERIALS & INTERFACES,9(22),18434-18439.
MLA Zhu, B,et al."Preservation of DNA Nanostructure Carriers: Effects of Freeze - Thawing and Ionic Strength during Lyophilization and Storage".ACS APPLIED MATERIALS & INTERFACES 9.22(2017):18434-18439.
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