CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Preservation of DNA Nanostructure Carriers: Effects of Freeze - Thawing and Ionic Strength during Lyophilization and Storage
Zhu, B; Zhao, Y; Dai, JB; Wang, JB; Xing, S; Guo, LJ; Chen, N; Qu, XM; Li, L; Shen, JW; Shi, JY; Li, J; Wang, LH
2017
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume9Issue:22Pages:18434-18439
Subtype期刊论文
AbstractDNA rianostiuctures have: attracted wide interest-in biomedical applications, especially as nanocarriers for drug delivery. Therefore, it is.important to ensure:the structural integrity of DNA nanostructures under ambient temperature storage. In this study, we examined lyophilization-based preservation of DNA nanostructures by investigating the structural integrity of different DNA nanostructures reconstituted from lyophilization. We demonstrated that lyophilization Under appropriate ionic strength is amenable to the storage of DNA. nanostructures Compared with that stored in liquid solutiOn, DNA nanostructure carriers reconstituted from lyophilization showed significantly better structural integrity after an accelerated aging test equivalent to 100-day room-temperature storage.
KeywordDelivery Stability Origami Nanoparticles Complexes
DOI10.1021/acsami.7b04784
WOS KeywordDELIVERY ; STABILITY ; ORIGAMI ; NANOPARTICLES ; COMPLEXES
Indexed BySCI
Language英语
WOS IDWOS:000403136400007
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/28780
Collection中科院上海应用物理研究所2011-2018年
Recommended Citation
GB/T 7714
Zhu, B,Zhao, Y,Dai, JB,et al. Preservation of DNA Nanostructure Carriers: Effects of Freeze - Thawing and Ionic Strength during Lyophilization and Storage[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(22):18434-18439.
APA Zhu, B.,Zhao, Y.,Dai, JB.,Wang, JB.,Xing, S.,...&Wang, LH.(2017).Preservation of DNA Nanostructure Carriers: Effects of Freeze - Thawing and Ionic Strength during Lyophilization and Storage.ACS APPLIED MATERIALS & INTERFACES,9(22),18434-18439.
MLA Zhu, B,et al."Preservation of DNA Nanostructure Carriers: Effects of Freeze - Thawing and Ionic Strength during Lyophilization and Storage".ACS APPLIED MATERIALS & INTERFACES 9.22(2017):18434-18439.
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