Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions

doi:10.1021/jacs.7b04040

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions
	Qu, XM; Wang, SP; Ge, ZL; Wang, JB; Yao, GB; Li, J; Zuo, XL; Shi, JY; Song, SP; Wang, LH; Li, L; Pei, H; Fan, CH
	2017
发表期刊	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN	0002-7863
卷号	139 期号:30 页码:10176-10179
文章类型	期刊论文
摘要	Programmable remodelling of cell surfaces enables high-precision regulation of cell behavior. In this work, we developed in vitro constructed DNA-based chemical reaction networks (CRNs) to program on-chip cell adhesion: We found that the RGD-functionalized DNA CRNs are entirely noninvasive when interfaced with the fluidic mosaic membrane of living cells. DNA toehold with different lengths could tunably alter the release kinetics of cells, which shows rapid release in minutes with the use of a 6-base toehold. We further demonstrated the realization of Boolean logic functions by using DNA strand displacement reactions, which include multi-input and sequential cell logic gates (AND, OR, XOR, and AND OR). This study provides a highly generic tool for self organization of biological systems.
关键词	Strand Displacement Cascades Dna Nanostructures Computation Microenvironments Amplification Monolayers Delivery Robots Array Ecm
DOI	10.1021/jacs.7b04040
关键词[WOS]	STRAND DISPLACEMENT CASCADES ; DNA NANOSTRUCTURES ; COMPUTATION ; MICROENVIRONMENTS ; AMPLIFICATION ; MONOLAYERS ; DELIVERY ; ROBOTS ; ARRAY ; ECM
收录类别	SCI
语种	英语
WOS记录号	WOS:000407089500003
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/28785
专题	中科院上海应用物理研究所2011-2018年
推荐引用方式 GB/T 7714	Qu, XM,Wang, SP,Ge, ZL,et al. Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2017,139(30):10176-10179.
APA	Qu, XM.,Wang, SP.,Ge, ZL.,Wang, JB.,Yao, GB.,...&Fan, CH.(2017).Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,139(30),10176-10179.
MLA	Qu, XM,et al."Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 139.30(2017):10176-10179.

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