Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions

doi:10.1021/jacs.7b04040

CAS OpenIR > 中科院上海应用物理研究所2011-2020年

	Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions
	Qu, XM; Wang, SP; Ge, ZL; Wang, JB; Yao, GB; Li, J; Zuo, XL; Shi, JY; Song, SP; Wang, LH; Li, L; Pei, H; Fan, CH
	2017
Source Publication	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN	0002-7863
Volume	139 Issue:30 Pages:10176-10179
Subtype	期刊论文
Abstract	Programmable remodelling of cell surfaces enables high-precision regulation of cell behavior. In this work, we developed in vitro constructed DNA-based chemical reaction networks (CRNs) to program on-chip cell adhesion: We found that the RGD-functionalized DNA CRNs are entirely noninvasive when interfaced with the fluidic mosaic membrane of living cells. DNA toehold with different lengths could tunably alter the release kinetics of cells, which shows rapid release in minutes with the use of a 6-base toehold. We further demonstrated the realization of Boolean logic functions by using DNA strand displacement reactions, which include multi-input and sequential cell logic gates (AND, OR, XOR, and AND OR). This study provides a highly generic tool for self organization of biological systems.
Keyword	Strand Displacement Cascades Dna Nanostructures Computation Microenvironments Amplification Monolayers Delivery Robots Array Ecm
DOI	10.1021/jacs.7b04040
Indexed By	SCI
WOS Keyword	STRAND DISPLACEMENT CASCADES ; DNA NANOSTRUCTURES ; COMPUTATION ; MICROENVIRONMENTS ; AMPLIFICATION ; MONOLAYERS ; DELIVERY ; ROBOTS ; ARRAY ; ECM
Language	英语
WOS ID	WOS:000407089500003
Citation statistics	Cited Times:72[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/28785
Collection	中科院上海应用物理研究所2011-2020年
Recommended Citation GB/T 7714	Qu, XM,Wang, SP,Ge, ZL,et al. Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2017,139(30):10176-10179.
APA	Qu, XM.,Wang, SP.,Ge, ZL.,Wang, JB.,Yao, GB.,...&Fan, CH.(2017).Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,139(30),10176-10179.
MLA	Qu, XM,et al."Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 139.30(2017):10176-10179.

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