Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions
Qu, XM; Wang, SP; Ge, ZL; Wang, JB; Yao, GB; Li, J; Zuo, XL; Shi, JY; Song, SP; Wang, LH; Li, L; Pei, H; Fan, CH
2017
发表期刊JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN0002-7863
卷号139期号:30页码:10176-10179
文章类型期刊论文
摘要Programmable remodelling of cell surfaces enables high-precision regulation of cell behavior. In this work, we developed in vitro constructed DNA-based chemical reaction networks (CRNs) to program on-chip cell adhesion: We found that the RGD-functionalized DNA CRNs are entirely noninvasive when interfaced with the fluidic mosaic membrane of living cells. DNA toehold with different lengths could tunably alter the release kinetics of cells, which shows rapid release in minutes with the use of a 6-base toehold. We further demonstrated the realization of Boolean logic functions by using DNA strand displacement reactions, which include multi-input and sequential cell logic gates (AND, OR, XOR, and AND OR). This study provides a highly generic tool for self organization of biological systems.
关键词Strand Displacement Cascades Dna Nanostructures Computation Microenvironments Amplification Monolayers Delivery Robots Array Ecm
DOI10.1021/jacs.7b04040
关键词[WOS]STRAND DISPLACEMENT CASCADES ; DNA NANOSTRUCTURES ; COMPUTATION ; MICROENVIRONMENTS ; AMPLIFICATION ; MONOLAYERS ; DELIVERY ; ROBOTS ; ARRAY ; ECM
收录类别SCI
语种英语
WOS记录号WOS:000407089500003
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28785
专题中科院上海应用物理研究所2011-2018年
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Qu, XM,Wang, SP,Ge, ZL,et al. Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2017,139(30):10176-10179.
APA Qu, XM.,Wang, SP.,Ge, ZL.,Wang, JB.,Yao, GB.,...&Fan, CH.(2017).Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,139(30),10176-10179.
MLA Qu, XM,et al."Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 139.30(2017):10176-10179.
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