Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions | |
| Qu, XM; Wang, SP; Ge, ZL; Wang, JB; Yao, GB; Li, J; Zuo, XL; Shi, JY; Song, SP; Wang, LH; Li, L; Pei, H; Fan, CH | |
| 2017 | |
| Source Publication | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| ISSN | 0002-7863 |
| Volume | 139Issue:30Pages:10176-10179 |
| Subtype | 期刊论文 |
| Abstract | Programmable remodelling of cell surfaces enables high-precision regulation of cell behavior. In this work, we developed in vitro constructed DNA-based chemical reaction networks (CRNs) to program on-chip cell adhesion: We found that the RGD-functionalized DNA CRNs are entirely noninvasive when interfaced with the fluidic mosaic membrane of living cells. DNA toehold with different lengths could tunably alter the release kinetics of cells, which shows rapid release in minutes with the use of a 6-base toehold. We further demonstrated the realization of Boolean logic functions by using DNA strand displacement reactions, which include multi-input and sequential cell logic gates (AND, OR, XOR, and AND OR). This study provides a highly generic tool for self organization of biological systems. |
| Keyword | Strand Displacement Cascades Dna Nanostructures Computation Microenvironments Amplification Monolayers Delivery Robots Array Ecm |
| DOI | 10.1021/jacs.7b04040 |
| Indexed By | SCI |
| WOS Keyword | STRAND DISPLACEMENT CASCADES ; DNA NANOSTRUCTURES ; COMPUTATION ; MICROENVIRONMENTS ; AMPLIFICATION ; MONOLAYERS ; DELIVERY ; ROBOTS ; ARRAY ; ECM |
| Language | 英语 |
| WOS ID | WOS:000407089500003 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/28785 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Recommended Citation GB/T 7714 | Qu, XM,Wang, SP,Ge, ZL,et al. Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2017,139(30):10176-10179. |
| APA | Qu, XM.,Wang, SP.,Ge, ZL.,Wang, JB.,Yao, GB.,...&Fan, CH.(2017).Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,139(30),10176-10179. |
| MLA | Qu, XM,et al."Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 139.30(2017):10176-10179. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| Programming Cell Adh（3215KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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