Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots | |
| Han, YP; Li, XM; Chen, HB; Hu, XJ; Luo, Y; Wang, T; Wang, ZJ; Li, Q; Fan, CH; Shi, JY; Wang, LH; Zhao, Y; Wu, CF; Chen, N | |
| 2017 | |
| Source Publication | ACS APPLIED MATERIALS & INTERFACES
 |
| ISSN | 1944-8244 |
| Volume | 9Issue:25Pages:21200-21208 |
| Subtype | 期刊论文 |
| Abstract | Semiconducting polymer dots (Pdots) have shown great promise in biomedical applications, including biosensing, drug delivery, and live imaging of cells and biomolecules. Insight into the mechanism and regulation of cellular uptake and intracellular metabolism. of Pdots is important for the development of superior Pdots-based theranostic nanoconjugates. Herein, we performed real-time imaging of endocytosis and intracellular trafficking of a type of fluorescent Pdots that showed excellent biocompatibility in various types of cells. The endocytic routes and kinetics of Pdots were differently regulated in distinct cell types. Following endocytosis, Pdots were transported in vesicles along micro tubule and destined for lysosomes. Furthermore, our results revealed exosome-mediated extracellular release of Pdots and have tracked the dynamic process at the single particle level. These results provide new insight into the design of more effective and selective imaging probes as well as drug carriers. |
| Keyword | Quantum Dots Cellular Uptake Drug-delivery Living Cells Live Cells Nanoparticles Cytotoxicity Fluorescence Transducer Insights |
| DOI | 10.1021/acsami.7b05662 |
| WOS Keyword | QUANTUM DOTS ; CELLULAR UPTAKE ; DRUG-DELIVERY ; LIVING CELLS ; LIVE CELLS ; NANOPARTICLES ; CYTOTOXICITY ; FLUORESCENCE ; TRANSDUCER ; INSIGHTS |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000404807200017 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/28795 |
| Collection | 中科院上海应用物理研究所2011-2018年 |
| Recommended Citation GB/T 7714 | Han, YP,Li, XM,Chen, HB,et al. Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(25):21200-21208. |
| APA | Han, YP.,Li, XM.,Chen, HB.,Hu, XJ.,Luo, Y.,...&Chen, N.(2017).Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots.ACS APPLIED MATERIALS & INTERFACES,9(25),21200-21208. |
| MLA | Han, YP,et al."Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots".ACS APPLIED MATERIALS & INTERFACES 9.25(2017):21200-21208. |
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| File Name/Size | DocType | Version | Access | License | ||
| Real-Time Imaging of（3871KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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