Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots
Han, YP; Li, XM; Chen, HB; Hu, XJ; Luo, Y; Wang, T; Wang, ZJ; Li, Q; Fan, CH; Shi, JY; Wang, LH; Zhao, Y; Wu, CF; Chen, N
2017
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号9期号:25页码:21200-21208
文章类型期刊论文
摘要Semiconducting polymer dots (Pdots) have shown great promise in biomedical applications, including biosensing, drug delivery, and live imaging of cells and biomolecules. Insight into the mechanism and regulation of cellular uptake and intracellular metabolism. of Pdots is important for the development of superior Pdots-based theranostic nanoconjugates. Herein, we performed real-time imaging of endocytosis and intracellular trafficking of a type of fluorescent Pdots that showed excellent biocompatibility in various types of cells. The endocytic routes and kinetics of Pdots were differently regulated in distinct cell types. Following endocytosis, Pdots were transported in vesicles along micro tubule and destined for lysosomes. Furthermore, our results revealed exosome-mediated extracellular release of Pdots and have tracked the dynamic process at the single particle level. These results provide new insight into the design of more effective and selective imaging probes as well as drug carriers.
关键词Quantum Dots Cellular Uptake Drug-delivery Living Cells Live Cells Nanoparticles Cytotoxicity Fluorescence Transducer Insights
DOI10.1021/acsami.7b05662
关键词[WOS]QUANTUM DOTS ; CELLULAR UPTAKE ; DRUG-DELIVERY ; LIVING CELLS ; LIVE CELLS ; NANOPARTICLES ; CYTOTOXICITY ; FLUORESCENCE ; TRANSDUCER ; INSIGHTS
收录类别SCI
语种英语
WOS记录号WOS:000404807200017
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文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28795
专题中科院上海应用物理研究所2011-2018年
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Han, YP,Li, XM,Chen, HB,et al. Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(25):21200-21208.
APA Han, YP.,Li, XM.,Chen, HB.,Hu, XJ.,Luo, Y.,...&Chen, N.(2017).Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots.ACS APPLIED MATERIALS & INTERFACES,9(25),21200-21208.
MLA Han, YP,et al."Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots".ACS APPLIED MATERIALS & INTERFACES 9.25(2017):21200-21208.
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