CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots
Han, YP; Li, XM; Chen, HB; Hu, XJ; Luo, Y; Wang, T; Wang, ZJ; Li, Q; Fan, CH; Shi, JY; Wang, LH; Zhao, Y; Wu, CF; Chen, N
2017
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume9Issue:25Pages:21200-21208
Subtype期刊论文
AbstractSemiconducting polymer dots (Pdots) have shown great promise in biomedical applications, including biosensing, drug delivery, and live imaging of cells and biomolecules. Insight into the mechanism and regulation of cellular uptake and intracellular metabolism. of Pdots is important for the development of superior Pdots-based theranostic nanoconjugates. Herein, we performed real-time imaging of endocytosis and intracellular trafficking of a type of fluorescent Pdots that showed excellent biocompatibility in various types of cells. The endocytic routes and kinetics of Pdots were differently regulated in distinct cell types. Following endocytosis, Pdots were transported in vesicles along micro tubule and destined for lysosomes. Furthermore, our results revealed exosome-mediated extracellular release of Pdots and have tracked the dynamic process at the single particle level. These results provide new insight into the design of more effective and selective imaging probes as well as drug carriers.
KeywordQuantum Dots Cellular Uptake Drug-delivery Living Cells Live Cells Nanoparticles Cytotoxicity Fluorescence Transducer Insights
DOI10.1021/acsami.7b05662
Indexed BySCI
WOS KeywordQUANTUM DOTS ; CELLULAR UPTAKE ; DRUG-DELIVERY ; LIVING CELLS ; LIVE CELLS ; NANOPARTICLES ; CYTOTOXICITY ; FLUORESCENCE ; TRANSDUCER ; INSIGHTS
Language英语
WOS IDWOS:000404807200017
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/28795
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Han, YP,Li, XM,Chen, HB,et al. Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(25):21200-21208.
APA Han, YP.,Li, XM.,Chen, HB.,Hu, XJ.,Luo, Y.,...&Chen, N.(2017).Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots.ACS APPLIED MATERIALS & INTERFACES,9(25),21200-21208.
MLA Han, YP,et al."Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots".ACS APPLIED MATERIALS & INTERFACES 9.25(2017):21200-21208.
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