Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots

doi:10.1021/acsami.7b05662

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots
	Han, YP; Li, XM; Chen, HB; Hu, XJ; Luo, Y; Wang, T; Wang, ZJ; Li, Q; Fan, CH; Shi, JY; Wang, LH; Zhao, Y; Wu, CF; Chen, N
	2017
发表期刊	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
卷号	9 期号:25 页码:21200-21208
文章类型	期刊论文
摘要	Semiconducting polymer dots (Pdots) have shown great promise in biomedical applications, including biosensing, drug delivery, and live imaging of cells and biomolecules. Insight into the mechanism and regulation of cellular uptake and intracellular metabolism. of Pdots is important for the development of superior Pdots-based theranostic nanoconjugates. Herein, we performed real-time imaging of endocytosis and intracellular trafficking of a type of fluorescent Pdots that showed excellent biocompatibility in various types of cells. The endocytic routes and kinetics of Pdots were differently regulated in distinct cell types. Following endocytosis, Pdots were transported in vesicles along micro tubule and destined for lysosomes. Furthermore, our results revealed exosome-mediated extracellular release of Pdots and have tracked the dynamic process at the single particle level. These results provide new insight into the design of more effective and selective imaging probes as well as drug carriers.
关键词	Quantum Dots Cellular Uptake Drug-delivery Living Cells Live Cells Nanoparticles Cytotoxicity Fluorescence Transducer Insights
DOI	10.1021/acsami.7b05662
关键词[WOS]	QUANTUM DOTS ; CELLULAR UPTAKE ; DRUG-DELIVERY ; LIVING CELLS ; LIVE CELLS ; NANOPARTICLES ; CYTOTOXICITY ; FLUORESCENCE ; TRANSDUCER ; INSIGHTS
收录类别	SCI
语种	英语
WOS记录号	WOS:000404807200017
引用统计
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/28795
专题	中科院上海应用物理研究所2011-2018年
推荐引用方式 GB/T 7714	Han, YP,Li, XM,Chen, HB,et al. Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(25):21200-21208.
APA	Han, YP.,Li, XM.,Chen, HB.,Hu, XJ.,Luo, Y.,...&Chen, N.(2017).Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots.ACS APPLIED MATERIALS & INTERFACES,9(25),21200-21208.
MLA	Han, YP,et al."Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots".ACS APPLIED MATERIALS & INTERFACES 9.25(2017):21200-21208.

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